Browsing by Author "Wang, Lingyan"
Now showing items 1-2 of 2
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NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses
Wang, Lingyan; Li, Shitao; Dorf, Martin Edward (Public Library of Science, 2012)RIG-I-like receptors (RLR) are intracellular sensors utilized by nearly all cell types for recognition of viral RNA, initiation of antiviral defense, and induction of type I interferons (IFN). TBK1 is a critical kinase ... -
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
Fu, Bishi; Wang, Lingyan; Ding, Hao; Schwamborn, Jens C.; Li, Shitao; Dorf, Martin E. (Public Library of Science, 2015)Polymerase basic protein 1 (PB1) is the catalytic core of the influenza A virus (IAV) RNA polymerase complex essential for viral transcription and replication. Understanding the intrinsic mechanisms which block PB1 function ...