Now showing items 1-14 of 14

    • Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons 

      Roberson, David P.; Gudes, Sagi; Sprague, Jared M.; Patoski, Haley A. W.; Robson, Victoria K.; Blasl, Felix; Duan, Bo; Oh, Seog Bae; Bean, Bruce P.; Ma, Qiufu; Binshtok, Alexander M.; Woolf, Clifford J. (2013)
      The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct ...
    • Bacteria activate sensory neurons that modulate pain and inflammation 

      Chiu, Isaac M.; Heesters, Balthasar A.; Ghasemlou, Nader; Von Hehn, Christian A.; Zhao, Fan; Tran, Johnathan; Wainger, Brian; Strominger, Amanda; Muralidharan, Sriya; Horswill, Alexander R.; Wardenburg, Juliane Bubeck; Hwang, Sun Wook; Carroll, Michael C.; Woolf, Clifford J. (2013)
      Summary Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviors. Bacterial infections produce pain ...
    • Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception 

      Neely, G. Gregory; Rao, Shuan; Costigan, Michael; Mair, Norbert; Racz, Ildiko; Milinkeviciute, Giedre; Meixner, Arabella; Nayanala, Swetha; Griffin, Robert Stewart; Belfer, Inna; Dai, Feng; Smith, Shad; Diatchenko, Luda; Marengo, Stefano; Haubner, Bernhard J.; Novatchkova, Maria; Gibson, Dustin; Maixner, William; Pospisilik, J. Andrew; Hirsch, Emilio; Whishaw, Ian Q.; Zimmer, Andreas; Gupta, Vaijayanti; Sasaki, Junko; Kanaho, Yasunori; Sasaki, Takehiko; Kress, Michaela; Woolf, Clifford; Penninger, Josef M. (Public Library of Science, 2012)
      The ability to perceive noxious stimuli is critical for an animal's survival in the face of environmental danger, and thus pain perception is likely to be under stringent evolutionary pressure. Using a neuronal-specific ...
    • Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain 

      Pertin, Marie; Allchorne, Andrew J; Beggah, Ahmed T; Woolf, Clifford; Decosterd, Isabelle (BioMed Central, 2007)
      Background: Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We ...
    • Detection of Cold Pain, Cold Allodynia and Cold Hyperalgesia in Freely Behaving Rats 

      Allchorne, Andrew J; Broom, Daniel C; Woolf, Clifford (BioMed Central, 2005)
      Background: Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold allodynia). To expand our understanding of cold induced pain ...
    • Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration 

      Painter, Michio Wendell; Brosius Lutz, Amanda; Cheng, Yung-Chih; Latremoliere, Alban; Duong, Kelly; Miller, Christine; Posada, Sean; Cobos, Enrique J.; Zhang, Alan; Wagers, Amy Jo; Havton, Leif A.; Barres, Ben; Omura, Takao; Woolf, Clifford (Elsevier BV, 2014)
      The regenerative capacity of the peripheral nervous system declines with age. Why this occurs, however, is unknown. We demonstrate that 24-month-old mice exhibit an impairment of functional recovery after nerve injury ...
    • Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations 

      Andrews, Nick A.; Latrémolière, Alban; Basbaum, Allan I.; Mogil, Jeffrey S.; Porreca, Frank; Rice, Andrew S.C.; Woolf, Clifford J.; Currie, Gillian L.; Dworkin, Robert H.; Eisenach, James C.; Evans, Scott; Gewandter, Jennifer S.; Gover, Tony D.; Handwerker, Hermann; Huang, Wenlong; Iyengar, Smriti; Jensen, Mark P.; Kennedy, Jeffrey D.; Lee, Nancy; Levine, Jon; Lidster, Katie; Machin, Ian; McDermott, Michael P.; McMahon, Stephen B.; Price, Theodore J.; Ross, Sarah E.; Scherrer, Grégory; Seal, Rebecca P.; Sena, Emily S.; Silva, Elizabeth; Stone, Laura; Svensson, Camilla I.; Turk, Dennis C.; Whiteside, Garth (Wolters Kluwer, 2016)
      Abstract There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in ...
    • Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts 

      Wainger, Brian J.; Buttermore, Elizabeth D.; Oliveira, Julia T.; Mellin, Cassidy; Lee, Seungkyu; Saber, Wardiya Afshar; Wang, Amy; Ichida, Justin K.; Chiu, Isaac M.; Barrett, Lee; Huebner, Eric A.; Bilgin, Canan; Tsujimoto, Naomi; Brenneis, Christian; Kapur, Kush; Rubin, Lee L.; Eggan, Kevin; Woolf, Clifford J. (2015)
      Reprogramming somatic cells from one cell fate to another can generate specific neurons suitable for disease modeling. To maximize the utility of patient-derived neurons, they must model not only disease-relevant cell ...
    • Photochemical activation of TRPA1 channels in neurons and animals 

      Kokel, David; Cheung, Chung Yan J.; Mills, Robert; Coutinho-Budd, Jaeda; Huang, Liyi; Setola, Vincent; Sprague, Jared; Jin, Shan; Jin, Youngnam N.; Huang, Xi-Ping; Bruni, Giancarlo; Woolf, Clifford; Roth, Bryan L.; Hamblin, Michael R; Zylka, Mark J.; Milan, David J.; Peterson, Randall T. (2013)
      Optogenetics is a powerful research tool because it enables high-resolution optical control of neuronal activity. However, current optogenetic approaches are limited to transgenic systems expressing microbial opsins and ...
    • Regeneration in the aging peripheral nervous system 

      Painter, Michio Wendell (2014-06-06)
      In the peripheral nervous system (PNS), aging is associated with a number of disorders, including a decline in regenerative capacity after injury. Although this decline has been observed in both rodents and humans for ...
    • Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation 

      Talbot, Sebastien; Abdulnour, Raja-Elie E; Burkett, Patrick Ryland; Lee, Seungkyu; Cronin, Shane J.F.; Pascal, Maud A.; Laedermann, Cedric; Foster, Simmie Lorene; Tran, Johnathan V.; Lai, Nicole Yin Yee; Chiu, Isaac Ming-Cheng; Ghasemlou, Nader; DiBiase, Matthew; Roberson, David P; Von Hehn, Christian; Agac, Busranour; Haworth, Oliver; Seki, Hiroyuki; Penninger, Josef M.; Kuchroo, Vijay Kumar; Bean, Bruce Palmer; Levy, Bruce David; Woolf, Clifford (Elsevier BV, 2015)
      Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release ...
    • A three-dimensional human neural cell culture model of Alzheimer’s disease 

      Choi, Se Hoon; Kim, Young Hye; Hebisch, Matthias; Sliwinski, Christopher; Lee, Seungkyu; D'Avanzo, Carla; Chen, Jennifer; Hooli, Basavaraj; Asselin, Caroline; Muffat, Julien; Klee, Justin B.; Zhang, Can; Wainger, Brian Jason; Peitz, Michael; Kovacs, Dora M.; Woolf, Clifford; Wagner, Steven L.; Tanzi, Rudolph Emile; Kim, Doo Yeon (Nature Publishing Group, 2014)
      Alzheimer’s disease (AD) is the most common form of dementia, characterized by two pathological hallmarks: β-amyloid plaques and neurofibrillary tangles1. The amyloid hypothesis of AD posits that excessive accumulation of ...
    • Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity 

      Chiu, Isaac M; Barrett, Lee B; Williams, Erika K; Strochlic, David E; Lee, Seungkyu; Weyer, Andy D; Lou, Shan; Bryman, Gregory S; Roberson, David P; Ghasemlou, Nader; Piccoli, Cara; Ahat, Ezgi; Wang, Victor; Cobos, Enrique J; Stucky, Cheryl L; Ma, Qiufu; Liberles, Stephen D; Woolf, Clifford J (eLife Sciences Publications, Ltd, 2014)
      The somatosensory nervous system is critical for the organism's ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles ...
    • TRPV1 Sensitization in Primary Sensory Neurons 

      Sprague, Jared Michael (2014-06-06)
      Pain is a major personal and community burden throughout the world with currently limited treatment options for persistent pain due to unacceptable side effects, dependence or frank inefficacy. It is necessary to understand ...