Now showing items 1-4 of 4

    • BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma 

      Jeong, Joseph H.; Wang, Zhenxiong; Ouyang, Xuesong; Jiang, Shan; Guney, Isil; Kang, Gyeong Hoon; Abate-Shen, Cory; Guimaraes, Alexander Savio Ramos; Figueiredo, Jose L.; Ding, Zhihu; Shin, Eyoung; Hahn, William C.; Loda, Massimo; Weissleder, Ralph; Chin, Lynda (Public Library of Science, 2008)
      Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic ...
    • Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development 

      Wiedemeyer, Ruprecht; Brennan, Cameron; Heffernan, Timothy P.; Xiao, Yonghong; Mahoney, John T.; Protopopov, Alexei; Zheng, Hongwu; Bignell, Graham; Furnari, Frank; Cavenee, Webster K.; Hahn, William C.; Ichimura, Koichi; Collins, Peter V.; Chu, Gerald C.; Stratton, Michael R.; Ligon, Keith Lloyd; Futreal, Andrew P.; Chin, Lynda (Cell Press, 2008)
      We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18^{INK4C} and p16^{INK4A} codeletion. Functional ...
    • Integrative Genome Comparison of Primary and Metastatic Melanomas 

      Kabbarah, Omar; Nogueira, Cristina; Feng, Bin; Bosenberg, Marcus; Scott, Kenneth L.; Xiao, Yonghong; Cordon-Cardo, Carlos; Wagner, Stephan N.; Brennan, Cameron; Nazarian, Rosalynn; Wu, Min; Kwong, Lawrence Noc-Woon; Granter, Scott R.; Ramaswamy, Sridhar; Golub, Todd R.; Duncan, Lyn M.; Chin, Lynda (Public Library of Science, 2010)
      A cardinal feature of malignant melanoma is its metastatic propensity. An incomplete view of the genetic events driving metastatic progression has been a major barrier to rational development of effective therapeutics and ...
    • Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy 

      Nitta, Masayuki; Stommel, Jayne; Ng, Kimberly; Kesari, Santosh; Furnari, Frank; Hoadley, Katherine A.; Cavenee, Webster K.; Kozono, David Eiichi; Kennedy, Richard; Zinn, Pascal Olivier; Kushwaha, Deepa S; Chin, Lynda; DePinho, Ronald A.; D'Andrea, Alan David; Chen, Clark Chin-Chung (Public Library of Science, 2010)
      Despite the critical role of Epidermal Growth Factor Receptor (EGFR) in glioblastoma pathogenesis [1], [2], EGFR targeted therapies have achieved limited clinical efficacy [3]. Here we propose an alternate therapeutic ...