Browsing by Author "Mallis, Robert"
Now showing items 1-3 of 3
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A Conserved Hydrophobic Patch on V\(\beta\) Domains Revealed by TCR\(\beta\) Chain Crystal Structures: Implications for Pre-TCR Dimerization
Zhou, Bo; Chen, Qiang; Mallis, Robert J.; Zhang, Hongmin; Liu, Jin-Huan; Reinherz, Ellis Leonard; Wang, Jiahuai (Frontiers Research Foundation, 2011)The \(\alpha\beta\) T cell receptor (TCR) is a multimeric complex whose \(\beta\) chain plays a crucial role in thymocyte development as well as antigen recognition by mature T lymphocytes. We report here crystal structures ... -
Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination
Brazin, Kristine N.; Mallis, Robert J.; Das, Dibyendu Kumar; Feng, Yinnian; Hwang, Wonmuk; Wang, Jia-huai; Wagner, Gerhard; Lang, Matthew J.; Reinherz, Ellis L. (Frontiers Media S.A., 2015)The αβTCR was recently revealed to function as a mechanoreceptor. That is, it leverages mechanical energy generated during immune surveillance and at the immunological synapse to drive biochemical signaling following ... -
TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling
Kim, Sun Taek; Sun, Zhen-Yu Jim; Shin, Yongdae; Brazin, Kristine N.; Mallis, Robert J.; Wagner, Gerhard; Lang, Matthew J.; Reinherz, Ellis Leonard (Frontiers Research Foundation, 2012)Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into ...