Now showing items 1-3 of 3

• #### A Conserved Hydrophobic Patch on V$\beta$ Domains Revealed by TCR$\beta$ Chain Crystal Structures: Implications for Pre-TCR Dimerization ﻿

(Frontiers Research Foundation, 2011)
The $\alpha\beta$ T cell receptor (TCR) is a multimeric complex whose $\beta$ chain plays a crucial role in thymocyte development as well as antigen recognition by mature T lymphocytes. We report here crystal structures ...
• #### Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination ﻿

(Frontiers Media S.A., 2015)
The αβTCR was recently revealed to function as a mechanoreceptor. That is, it leverages mechanical energy generated during immune surveillance and at the immunological synapse to drive biochemical signaling following ...
• #### TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling ﻿

(Frontiers Research Foundation, 2012)
Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into ...