Browsing by Author "Snapper, Scott"

Now showing items 1-7 of 7

    • CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types 

      Nelms, Bradlee D.; Waldron, Levi; Barrera, Luis A.; Weflen, Andrew W.; Goettel, Jeremy A.; Guo, Guoji; Montgomery, Robert K.; Neutra, Marian R.; Breault, David T.; Snapper, Scott B.; Orkin, Stuart H.; Bulyk, Martha L.; Huttenhower, Curtis; Lencer, Wayne I. (BioMed Central, 2016)
      We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our ...

    • Characterization of Adherent Bacteroidales from Intestinal Biopsies of Children and Young Adults with Inflammatory Bowel Disease 

      Zitomersky, Naamah L.; Atkinson, Benjamin J.; Franklin, Sarah W.; Mitchell, Paul D.; Snapper, Scott B.; Comstock, Laurie E.; Bousvaros, Athos (Public Library of Science, 2013)
      There is extensive evidence implicating the intestinal microbiota in inflammatory bowel disease [IBD], but no microbial agent has been identified as a sole causative agent. Bacteroidales are numerically dominant intestinal ...

    • Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells 

      Baptista, Marisa A. P.; Keszei, Marton; Oliveira, Mariana; Sunahara, Karen K. S.; Andersson, John; Dahlberg, Carin I. M.; Worth, Austen J.; Liedén, Agne; Kuo, I-Chun; Wallin, Robert P. A.; Snapper, Scott B.; Eidsmo, Liv; Scheynius, Annika; Karlsson, Mikael C. I.; Bouma, Gerben; Burns, Siobhan O.; Forsell, Mattias N. E.; Thrasher, Adrian J.; Nylén, Susanne; Westerberg, Lisa S. (Nature Publishing Group, 2016)
      Wiskott–Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WASp gene. Decreased cellular responses in WASp-deficient cells have been interpreted to mean that WASp directly regulates these responses in ...

    • Dysfunction of the Intestinal Microbiome in Inflammatory Bowel Disease and Treatment 

      Morgan, Xochitl C; Sokol, Harry; Gevers, Dirk; Ward, Doyle V; LeLeiko, Neal; Sands, Bruce E; Tickle, Timothy L.; Devaney, Kathryn L; Reyes, Joshua Anthony; Shah, Samir A; Snapper, Scott Brian; Bousvaros, Athos; Korzenik, Joshua; Xavier, Ramnik; Huttenhower, Curtis (BioMed Central, 2012)
      Background: The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in ...

    • Higher Activity of the Inducible Nitric Oxide Synthase Contributes to Very Early Onset Inflammatory Bowel Disease 

      Dhillon, Sandeep S; Mastropaolo, Lucas A; Murchie, Ryan; Griffiths, Christopher; Thöni, Cornelia; Elkadri, Abdul; Xu, Wei; Mack, Amanda; Walters, Thomas; Guo, Conghui; Mack, David; Huynh, Hien; Baksh, Shairaz; Silverberg, Mark S; Brumell, John H; Snapper, Scott B; Muise, Aleixo M (Nature Publishing Group, 2014)
      OBJECTIVES: The NOS2 gene encodes for the inducible nitric oxide synthase (iNOS), responsible for nitric oxide (NO) production, which contributes to antimicrobial and antipathogenic activities. Higher levels of both iNOS ...

    • N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling 

      Liu, Chaohong; Bai, Xiaoming; Wu, Junfeng; Sharma, Shruti; Upadhyaya, Arpita; Dahlberg, Carin I. M.; Westerberg, Lisa S.; Snapper, Scott B.; Zhao, Xiaodong; Song, Wenxia (Public Library of Science, 2013)
      Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for suppressing the ...

    • N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier 

      Xiao, Xiang; Mruk, Dolores D.; Tang, Elizabeth I.; Massarwa, R'ada; Mok, Ka Wai; Li, Nan; Wong, Chris K. C.; Lee, Will M.; Snapper, Scott B.; Shilo, Ben-Zion; Schejter, Eyal D.; Cheng, C. Yan (Public Library of Science, 2014)
      During spermatogenesis, the blood-testis barrier (BTB) segregates the adluminal (apical) and basal compartments in the seminiferous epithelium, thereby creating a privileged adluminal environment that allows post-meiotic ...