Now showing items 1-4 of 4

    • A Conserved CCCH-type Zinc Finger Protein Regulates mRNA Nuclear Adenylation and Export 

      Hurt, Jessica A.; Obar, Robert Alan; Zhai, Bo; Farny, Natalie G.; Gygi, Steven P.; Silver, Pamela A. (The Rockefeller University Press, 2009)
      Coupling of messenger RNA (mRNA) nuclear export with prior processing steps aids in the fidelity and efficiency of mRNA transport to the cytoplasm. In this study, we show that the processes of export and polyadenylation ...
    • Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export 

      Lei, Haixin; Zhai, Bo; Yin, Shanye; Gygi, Steve; Reed, Robin (Oxford University Press, 2012)
      We previously showed that mRNAs synthesized from three genes that naturally lack introns contain a portion of their coding sequence, known as a cytoplasmic accumulation region (CAR), which is essential for stable accumulation ...
    • TAK1 is an Essential Regulator of BMP Signalling in Cartilage 

      Shim, Jae-Hyuck; Greenblatt, Matthew Blake; Xie, Min; Schneider, Michael D; Zou, Weigou; Zhai, Bo; Gygi, Steven P.; Glimcher, Laurie Hollis (Nature Publishing Group, 2009)
      TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...
    • Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy 

      Cohen, Shenhav Orit; Zhai, Bo; Gygi, Steven P.; Goldberg, Alfred L. (The Rockefeller University Press, 2012)
      During muscle atrophy, myofibrillar proteins are degraded in an ordered process in which MuRF1 catalyzes ubiquitylation of thick filament components (Cohen et al. 2009. J. Cell Biol. http://dx.doi.org/10.1083/jcb.200901052). ...