Now showing items 1-2 of 2

    • Edgetic Perturbation Models of Human Inherited Disorders 

      Simonis, Nicolas; Li, Qian-Ru; Heuze, Fabien; Klitgord, Niels; Tam, Stanley; Venkatesan, Kavitha; Mou, Danny; Swearingen, Venus; Yildirim, Muhammed A; Dricot, Amélie; Szeto, David; Lin, Chenwei; Hao, Tong; Fan, Changyu; Milstein, Stuart; Dupuy, Denis; Brasseur, Robert; Zhong, Quan; Charloteaux, Benoit; Yu, Haiyuan; Yan, Han; Hill, David E.; Cusick, Michael; Vidal, Marc (Nature Publishing Group, 2009)
      Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes' and ‘edges', respectively. Better ...
    • A Yeast Model of FUS/TLS-Dependent Cytotoxicity 

      Ju, Shulin; Tardiff, Daniel F.; Han, Haesun; Divya, Kanneganti; Maquat, Lynne E.; Bosco, Daryl A.; Hayward, Lawrence J.; Lindquist, Susan; Weissman, Jonathan S.; Zhong, Quan; Brown, Robert H.; Ringe, Dagmar; Petsko, Gregory A. (Public Library of Science, 2011)
      FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...