Now showing items 1-13 of 13

    • Altered Chromosomal Topology Drives Oncogenic Programs in SDH-Deficient GISTs 

      Flavahan, William A.; Drier, Yotam; Johnstone, Sarah E.; Hemming, Matthew; Tarjan, Daniel R.; Hegazi, Esmat; Shareef, Sarah; Javed, Nauman; Eschle, Benjamin K.; Gokhale, Prafulla C.; Hornick, Jason; Sicinska, Ewa; Demetri, George; Bernstein, Bradley (Springer Science and Business Media LLC, 2019-10-16)
      Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have ...
    • Buried Barrett's Epithelium Following Photodynamic Therapy Shows Reduced Crypt Proliferation and Absence of DNA Content Abnormalities 

      Hornick, Jason L.; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Liu, Weitian; Goyal, Raj K.; Odze, Robert D. (Springer Nature, 2008)
      OBJECTIVES: Photodynamic therapy (PDT) is increasingly used for the treatment of patients with Barrett's esophagus (BE) with dysplasia or early carcinoma. Post-PDT, some patients show residual BE either exposed to the ...
    • Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases 

      Kapoor, Neena; Shinagare, Atul B.; Jagannathan, Jyothi P.; Shah, Shaan H.; Krajewski, Katherine M.; Hornick, Jason L.; Ramaiya, Nikhil H. (Versita, Warsaw, 2014)
      Background: The aim of the study was to evaluate the clinical and imaging features of extraskeletal myxoid chondrosarcoma (EMC) including initial presentation, recurrence, and metastases. Patients and methods. In this ...
    • Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas 

      Sholl, Lynette Marie; Weremowicz, Stanislawa; Gray, Stacy; Wong, Kwok-Kin; Chirieac, Lucian Radu; Lindeman, Neal I.; Hornick, Jason L. (Elsevier BV, 2013)
      INTRODUCTION ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK overexpression and predicting response to targeted therapy. Fluorescence in situ hybridization (FISH) is the gold standard ...
    • Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry 

      Kluk, Michael J.; Ashworth, Todd; Wang, Hongfang; Knoechel, Birgit; Mason, Emily F.; Morgan, Elizabeth A.; Dorfman, David; Pinkus, Geraldine; Weigert, Oliver; Hornick, Jason L.; Chirieac, Lucian R.; Hirsch, Michelle; Oh, David J.; South, Andrew P.; Leigh, Irene M.; Pourreyron, Celine; Cassidy, Andrew J.; DeAngelo, Daniel J.; Weinstock, David M.; Krop, Ian E.; Dillon, Deborah; Brock, Jane E.; Lazar, Alexander J. F.; Peto, Myron; Cho, Raymond J.; Stoeck, Alexander; Haines, Brian B.; Sathayanrayanan, Sriram; Rodig, Scott; Aster, Jon C. (Public Library of Science, 2013)
      Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been ...
    • Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA 

      Beadling, Carol; Patterson, Janice; Justusson, Emily; Nelson, Dylan; Pantaleo, Maria A.; Hornick, Jason L.; Chacón, Matias; Corless, Christopher L.; Heinrich, Michael C. (Blackwell Publishing Ltd, 2013)
      Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal (ICCs) and are the most common mesenchymal neoplasm of the gastrointestinal tract. While the majority of GISTs harbor activating mutations ...
    • Interobserver Variability in the Diagnosis of Crypt Dysplasia in Barrett Esophagus 

      Coco, Dominique P.; Goldblum, John R.; Hornick, Jason L.; Lauwers, Gregory Y.; Montgomery, Elizabeth; Srivastava, Amitabh; Wang, Helen; Odze, Robert D. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Recent morphologic and molecular evidence suggests that dysplasia in Barrett esophagus (BE) begins in the bases of the crypts [crypt dysplasia (CD)] and progresses with time to involve the upper portions of the crypts and ...
    • Metastatic pattern of uterine leiomyosarcoma: retrospective analysis of the predictors and outcome in 113 patients 

      Tirumani, Sree Harsha; Deaver, Pamela; Shinagare, Atul B.; Tirumani, Harika; Hornick, Jason L.; George, Suzanne; Ramaiya, Nikhil H. (Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology, 2014)
      Objective: To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. Methods: We included 113 women (mean age, 53 years; range, 29 to 72 years) with ...
    • A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-rearranged Lung Adenocarcinomas by Standard Immunohistochemistry 

      Mino-Kenudson, Mari; Chirieac, Lucian; Law, Kenny; Hornick, Jason; Lindeman, Neal; Mark, Eugene; Cohen, David W.; Johnson, Bruce; Janne, Pasi; Iafrate, Anthony; Rodig, Scott (American Association for Cancer Research, 2010-03)
      Purpose Approximately 5% of lung adenocarcinomas harbor an EML4-ALK gene fusion and define a unique tumor group that may be responsive to targeted therapy. However ALK-rearranged lung adenocarcinomas are difficult to ...
    • Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms 

      Elias, Kevin Meyer; Labidi-Galy, S. Intidhar; Vitonis, Allison F.; Hornick, Jason L.; Doyle, Leona Adrienne; Hirsch, Michelle S.; Cramer, Daniel William; Drapkin, Ronny (Elsevier BV, 2014)
      Background Due to concern that mucinous malignant or borderline ovarian neoplasms (MON) may represent metastatic deposits from appendiceal primaries, gynecologic oncologists routinely perform appendectomy in these cases. ...
    • Sequence-Based Discovery of Bradyrhizobium enterica in Cord Colitis Syndrome 

      Bhatt, Ami Bharat; Freeman, Sam Spenser Sharpe; Herrera, Alex Francisco; Pedamallu, Chandra Sekhar; Gevers, Dirk; Duke, Fujiko; Jung, Joonil; Michaud, Monia; Walker, Bruce David; Young, Sally U.; Earl, Ashlee M.; Kostic, Aleksander D.; Ojesina, Akinyemi Ifedapo; Hasserjian, Robert Paul; Ballen, Karen Kuhn; Chen, Yi-Bin Albert; Hobbs, Gabriela; Antin, Joseph Harry; Soiffer, Robert Jon; Baden, Lindsey Robert; Garrett, Wendy S.; Hornick, Jason L.; Marty, Francisco Miguel; Meyerson, Matthew Langer (New England Journal of Medicine (NEJM/MMS), 2013)
      BACKGROUND—Immunosuppression is associated with a variety of idiopathic clinical syndromes that may have infectious causes. It has been hypothesized that the cord colitis syndrome, a complication of umbilical-cord ...
    • SOX15 Governs Transcription in Human Stratified Epithelia and a Subset of Esophageal Adenocarcinomas 

      Sulahian, Rita; Chen, Justina; Arany, Zoltan; Jadhav, Unmesh; Peng, Shouyong; Rustgi, Anil K.; Bass, Adam; Srivastava, Amitabh; Hornick, Jason; Shivdasani, Ramesh (Elsevier BV, 2015-11)
      Background & Aims Intestinal metaplasia (Barrett’s esophagus, BE) is the principal risk factor for esophageal adenocarcinoma (EAC). Study of the basis for BE has centered on intestinal factors, but loss of esophageal ...
    • Sox2 Protein Expression is an Independent Poor Prognostic Indicator in Stage I Lung Adenocarcinoma 

      Sholl, Lynette Marie; Barletta, Justine Anastasia; Yeap, Beow Yong; Chirieac, Lucian Radu; Hornick, Jason L. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Many patients with stage I non-small cell lung carcinoma will develop recurrence following surgical excision. Sox2 is a marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior and is ...