Browsing by Author "Goldsmith, Jeffrey"

Now showing items 1-7 of 7

    • Alpha-CTLA-4 mAb-associated Panenteritis: A Histologic and Immunohistochemical Analysis 

      Oble, Darryl A.; Mino-Kenudson, Mari; Goldsmith, Jeffrey David; Hodi, Frank Stephen; Seliem, Rania M.; Dranoff, Glenn; Mihm, Martin Charles; Hasserjian, Robert Paul; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. ...

    • Analysis of Multiple Sarcoma Expression Datasets: Implications for Classification, Oncogenic Pathway Activation and Chemotherapy Resistance 

      Konstantinopoulos, Panagiotis; Fountzilas, Elena; Goldsmith, Jeffrey David; Bhasin, Manoj; Pillay, Kamana; Francoeur, Nancy; Libermann, Towia Aron; Gebhardt, Mark Clyde; Spentzos, Dimitrios (Public Library of Science, 2010)
      Background: Diagnosis of soft tissue sarcomas (STS) is challenging. Many remain unclassified (not-otherwise-specified, NOS) or grouped in controversial categories such as malignant fibrous histiocytoma (MFH), with unclear ...

    • A Genetic Screen Identifies an LKB1–MARK Signalling Axis Controlling the Hippo–YAP Pathway 

      Mohseni, Morvarid; Sun, Jianlong; Lau, Allison; Curtis, Stephen; Goldsmith, Jeffrey; Fox, Victor; Wei, Chongjuan; Frazier, Marsha; Samson, Owen; Wong, Kwok-Kim; Kim, Carla; Camargo, Fernando (Springer Nature, 2014-01)
      The Hippo-YAP pathway is an emerging signalling cascade involved in the regulation of stem cell activity and organ size. To identify components of this pathway, we performed an RNAi-based kinome screen in human cells. Our ...

    • A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study 

      Fountzilas, Elena; Kelly, Andrew D; Perez-Atayde, Antonio Rafael; Goldsmith, Jeffrey David; Konstantinopoulos, Panagiotis; Francoeur, Nancy; Correll, Mick; Rubio, Renee; Hu, Lan; Gebhardt, Mark Clyde; Quackenbush, John; Spentzos, Dimitrios (BioMed Central, 2012)
      Background: MicroRNAs (miRNAs) are nucleic acid regulators of many human mRNAs, and are associated with many tumorigenic processes. miRNA expression levels have been used in profiling studies, but some evidence suggests ...

    • MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32 

      Kelly, Andrew D; Haibe-Kains, Benjamin; Janeway, Katherine A; Hill, Katherine E; Howe, Eleanor; Goldsmith, Jeffrey; Kurek, Kyle; Perez-Atayde, Antonio R; Francoeur, Nancy; Fan, Jian-Bing; April, Craig; Schneider, Hal; Gebhardt, Mark C; Culhane, Aedin; Quackenbush, John; Spentzos, Dimitrios (BioMed Central, 2013)
      Background: Although microRNAs (miRNAs) are implicated in osteosarcoma biology and chemoresponse, miRNA prognostic models are still needed, particularly because prognosis is imperfectly correlated with chemoresponse. ...

    • Predictors of Endoscopic Inflammation in Patients with Ulcerative Colitis in Clinical Remission 

      Rosenberg, Laura; Lawlor, Garreth O.; Zenlea, Talia; Goldsmith, Jeffrey; Gifford, Anne; Falchuk, Kenneth; Wolf, Jacqueline; Cheifetz, Adam; Robson, Simon; Moss, Alan C. (Oxford University Press (OUP), 2013-04-01)
      Objectives Patients with ulcerative colitis (UC) who are in clinical remission may still have underlying endoscopic inflammation, which is associated with inferior clinical outcomes. The goal of this study was to determine ...

    • Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation 

      Chen, Xinhua; Yang, Guoxun; Song, Joo-Hye; Xu, Huansheng; Li, Dan; Goldsmith, Jeffrey David; Zeng, Huiyan; Parsons-Wingerter, Patricia A.; Reinecker, Hans-Christian; Kelly, Ciaran Patrick (Public Library of Science, 2013)
      Background and Aims Saccharomyces boulardii (Sb) can protect against intestinal injury and tumor formation, but how this probiotic yeast controls protective mucosal host responses is unclear. Angiogenesis is an integral ...