Now showing items 1-6 of 6

    • Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors 

      Eberlin, L. S.; Norton, I.; Orringer, D.; Dunn, Ian Frederick; Liu, X.; Ide, J. L.; Jarmusch, A. K.; Ligon, Keith Lloyd; Jolesz, Ferenc A.; Golby, Alexandra Jacqueline; Santagata, Sandro; Agar, Nathalie Marie Yvonne Rachel; Cooks, R. G. (Proceedings of the National Academy of Sciences, 2013)
      The main goal of brain tumor surgery is to maximize tumor resection while preserving brain function. However, existing imaging and surgical techniques do not offer the molecular information needed to delineate tumor ...
    • Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery 

      Agar, Nathalie Marie Yvonne Rachel; Golby, Alexandra Jacqueline; Ligon, Keith Lloyd; Norton, Isaiah Hakim; Mohan, Vandana; Wiseman, Justin M; Tannenbaum, Allen; Jolesz, Ferenc A. (Oxford University Press (OUP), 2011)
      BACKGROUND: Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. ...
    • Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry 

      Eberlin, Livia S.; Dill, Allison L.; Golby, Alexandra Jacqueline; Ligon, Keith Lloyd; Wiseman, Justin M.; Cooks, R. Graham; Agar, Nathalie Marie Yvonne Rachel (Wiley-Blackwell, 2010)
    • Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival 

      Agar, Jeffrey N.; Wang, Qi; Johnson, Joshua L.; Agar, Nathalie Marie Yvonne Rachel (Public Library of Science, 2008)
      The nature of the “toxic gain of function” that results from amyotrophic lateral sclerosis (ALS)-, Parkinson-, and Alzheimer-related mutations is a matter of debate. As a result no adequate model of any neurodegenerative ...
    • Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy 

      Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian Wilhelm; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra Jacqueline; Norton, Isaiah Hakim; Hayashi, Marika; Agar, Nathalie Marie Yvonne Rachel; Young, Geoffrey; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith Lloyd; Sagher, Oren; Xie, Xiaoliang Sunney (American Association for the Advancement of Science (AAAS), 2013)
      Surgery is an essential component in the treatment of brain tumors. However, delineating tumor from normal brain remains a major challenge. We describe the use of stimulated Raman scattering (SRS) microscopy for ...
    • Structural Characterization of Pandoraea pnomenusa B-356 Biphenyl Dioxygenase Reveals Features of Potent Polychlorinated Biphenyl-Degrading Enzymes 

      Colbert, Christopher L.; Agar, Nathalie Marie Yvonne Rachel; Kumar, Pravindra; Chakko, Mathew N.; Sinha, Sangita C.; Powlowski, Justin B.; Eltis, Lindsay D.; Bolin, Jeffrey T. (Public Library of Science, 2013)
      The oxidative degradation of biphenyl and polychlorinated biphenyls (PCBs) is initiated in Pandoraea pnomenusa B-356 by biphenyl dioxygenase \((BPDO_{B356})\). \(BPDO_{B356}\), a heterohexameric \((αβ)_3\) Rieske oxygenase ...