Now showing items 1-9 of 9

    • Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants 

      Cornelissen, Laura Louise; Kim, Seong-Eun; Purdon, Patrick Lee; Brown, Emery Neal; Berde, Charles Benjamin (eLife Sciences Organisation, Ltd., 2015)
      Electroencephalogram (EEG) approaches may provide important information about developmental changes in brain-state dynamics during general anesthesia. We used multi-electrode EEG, analyzed with multitaper spectral methods ...
    • Electroencephalography during general anaesthesia differs between term-born and premature-born children 

      Poorun, Ravi; Hartley, Caroline; Goksan, Sezgi; Worley, Alan; Boyd, Stewart; Cornelissen, Laura Louise; Berde, Charles Benjamin; Rogers, Richard George; Ali, Tariq; Slater, Rebeccah (Elsevier BV, 2016)
      OBJECTIVES: Premature birth is associated with a wide range of complications in later life, including structural and functional neurological abnormalities and altered pain sensitivity. We investigated whether during ...
    • Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine 

      Bajic, Dusica; Soiza-Reilly, Mariano; Spalding, Allegra L.; Berde, Charles B.; Commons, Kathryn G. (Public Library of Science, 2015)
      Neuroplasticity in the mesolimbic dopaminergic system is critical for behavioral adaptations associated with opioid reward and addiction. These processes may be influenced by cholinergic transmission arising from the ...
    • Neurodevelopmental outcome at two years of age after general and awake-regional anaesthesia in infancy: a randomised controlled trial 

      Davidson, Andrew J.; Disma, Nicola; de Graaff, Jurgen C.; Withington, Davinia E.; Dorris, Liam; Bell, Graham; Stargatt, Robyn; Bellinger, David C.; Schuster, Tibor; Arnup, Sarah J.; Hardy, Pollyanna; Hunt, Rodney W.; Takagi, Michael J.; Giribaldi, Gaia; Hartmann, Penelope L.; Salvo, Ida; Morton, Neil S.; von Ungern Sternberg, Britta S; Locatelli, Bruno Guido; Wilton, Niall; Lynn, Anne; Thomas, Joss J.; Polaner, David; Bagshaw, Oliver; Szmuk, Peter; Absalom, Anthony R.; Frawley, Geoff; Berde, Charles; Ormond, Gillian D; Marmor, Jacki; Ellen, Mary (2016)
      Summary Background: There is pre-clinical evidence that general anaesthetics affect brain development. There is mixed evidence from cohort studies that young children exposed to anaesthesia may have an increased risk of ...
    • Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study 

      Cornelissen, Laura; Donado, Carolina; Kim, Joseph; Chiel, Laura; Zurakowski, David; Logan, Deirdre E; Meier, Petra; Sethna, Navil F; Blankenburg, Markus; Zernikow, Boris; Sundel, Robert P; Berde, Charles B (BioMed Central, 2014)
      Background: Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies ...
    • A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia 

      Lobo, Kimberly; Donado, Carolina; Cornelissen, Laura Louise; Kim, Joseph; Ortiz, Rebeca; Peake, Roy; Kellogg, Mark David; Alexander, Mark Edward; Zurakowski, David; Kurgansky, Katherine E.; Peyton, James Matthew; Bilge, Aykut; Boretsky, Karen Rach; McCann, Mary Ellen; Berde, Charles Benjamin; Cravero, Joseph Peter (Ovid Technologies (Wolters Kluwer Health), 2015)
      BACKGROUND: Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, ...
    • Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia 

      Berde, Charles Benjamin; Athiraman, Umeshkumar; Yahalom, Barak; Zurakowski, David; Corfas, Gabriel; Bognet, Christina (Molecular Diversity Preservation International (MDPI), 2011)
      Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, ...
    • Transient alterations of cutaneous sensory nerve function by non-invasive cryolipolysis 

      Garibyan, Lilit; Cornelissen, Laura; Sipprell, William; Pruessner, Joachim; Elmariah, Sarina; Luo, Tuan; Lerner, Ethan A.; Jung, Yookyung; Evans, Conor; Zurakowski, David; Berde, Charles B.; Rox Anderson, R. (2015)
      Cryolipolysis is a non-invasive, skin cooling treatment for local fat reduction that causes prolonged hypoesthesia over the treated area. We tested the hypothesis that cryolipolysis can attenuate nociception of a range of ...
    • Transient and Persistent Pain Induced Connectivity Alterations in Pediatric Complex Regional Pain Syndrome 

      Linnman, Clas; Becerra, Lino; Lebel, Alyssa; Berde, Charles Benjamin; Grant, P. Ellen; Borsook, David (Public Library of Science, 2013)
      Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful ...