Now showing items 1-4 of 4

    • Metabolic Heterogeneity in Molecular Subsets of Diffuse Large B-cell Lymphoma 

      Stanley, Illana Allake (2014-10-21)
      Cells adapt their metabolism to satisfy changing bioenergetic and biosynthetic needs. Investigation of metabolic reprogramming in cancer has provided insight into the metabolic control of proliferation and survival. While ...
    • Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts 

      Shah, Dhvanit I; Takahashi-Makise, Naoko; Cooney, Jeffrey D.; Li, Liangtao; Schultz, Iman J.; Pierce, Eric L.; Narla, Anupama; Seguin, Alexandra; Hattangadi, Shilpa M.; Medlock, Amy E.; Langer, Nathaniel B.; Dailey, Tamara A.; Hurst, Slater N.; Faccenda, Danilo; Wiwczar, Jessica M.; Heggers, Spencer K.; Vogin, Guillaume; Chen, Wen; Chen, Caiyong; Campagna, Dean R.; Brugnara, Carlo; Zhou, Yi; Ebert, Benjamin L.; Danial, Nika; Fleming, Mark Daniel; Ward, Diane M.; Campanella, Michelangelo; Dailey, Harry A.; Kaplan, Jerry; Paw, Barry Htin (2012)
      SUMMARY Defects in the availability of heme substrates or the catalytic activity of the terminal enzyme in heme biosynthesis, ferrochelatase (Fech), impair heme synthesis, and thus cause human congenital anemias1,2. The ...
    • Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting 

      Fu, Suneng; Fan, Jason; Blanco, Joshua Aaron; Gimenez-Cassina, Alfredo; Danial, Nika; Watkins, Steve M.; Hotamisligil, Gökhan S. (Public Library of Science, 2012)
      Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed ...
    • Regulation of Tumor Necrosis Factor-Induced Cell Death and Toll-Like Receptor-Mediated Activation of Macrophages by SPATA2 

      Zhou, Wen (2015-05-17)
      Cell death and innate immunity are interconnected events for multicellular organisms to defend against pathogenic microbes and restrict tissue damage. Macrophages constitute an important population of innate immunity. Their ...