Browsing by Author "Deloid, Glen"
Now showing items 1-5 of 5
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Advanced computational modeling for in vitro nanomaterial dosimetry
DeLoid, Glen M.; Cohen, Joel M.; Pyrgiotakis, Georgios; Pirela, Sandra V.; Pal, Anoop; Liu, Jiying; Srebric, Jelena; Demokritou, Philip (BioMed Central, 2015)Background: Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells “see,” ... -
Development and characterization of a Versatile Engineered Nanomaterial Generation System (VENGES) suitable for toxicological studies
Demokritou, Phil K.; Büchel, Robert; Molina, Ramon M.; Deloid, Glen M; Brain, Joseph David; Pratsinis, Sotiris E. (Informa Healthcare, 2010)A novel system for generation of engineered nanomaterials (ENMs) suitable for in situ toxicological characterization within biological matrices was developed. This Versatile Engineered Nanomaterial Generation System (VENGES) ... -
Genome-Wide RNAi Screen in \(IFN-\gamma-Treated\) Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis
Zhou, Hongwei; Browning, Erica; Tan, Fengxiao; Imrich, Amy; Kramnik, Igor; Gregory, David James; Koziel, Henryk; Lu, Quan; Kobzik, Lester; DeLoid, Glen M.; Bedugnis, Alice (Public Library of Science, 2012)Interferon-gamma \((IFN-\gamma)\) inhibits intracellular replication of Francisella tularensis in human monocyte-derived macrophages (HMDM) and in mice, but the mechanisms of this protective effect are poorly characterized. ... -
Heterogeneity in Macrophage Phagocytosis of Staphylococcus aureus Strains: High-Throughput Scanning Cytometry-Based Analysis
Sulahian, Timothy H.; Imrich, Amy; Deloid, Glen M; Kobzik, Lester (Public Library of Science, 2009)Alveolar macrophages (AMs) can phagocytose unopsonized pathogens such as S. aureus via innate immune receptors, such as scavenger receptors (SRs). Cytoskeletal events and signaling pathways involved in phagocytosis of ... -
Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry
Sulahian, Timothy H; Imrich, Amy; Winkler, Aaron R; Deloid, Glen M; Kobzik, Lester (BioMed Central, 2008)Background: Scavenger receptors are important components of the innate immune system in the lung, allowing alveolar macrophages to bind and phagocytose numerous unopsonized targets. Mice with genetic deletions of scavenger ...