Now showing items 1-7 of 7

    • Detection of JC Virus-Specific Immune Responses in a Novel Humanized Mouse Model 

      Tan, Chen; Broge, Thomas A.; Seung, Edward N.; Vrbanac, Vladimir; Viscidi, Raphael; Gordon, Jennifer; Tager, Andrew Martin; Koralnik, Igor J. (Public Library of Science, 2013)
      Progressive Multifocal Leukoencephalopathy (PML) is an often fatal disease caused by the reactivation of the JC virus (JCV). Better understanding of viral-host interactions has been hampered by the lack of an animal model. ...
    • Evolutionarily Conserved Recognition and Innate Immunity to Fungal Pathogens by the Scavenger Receptors SCARF1 and CD36 

      Tampakakis, Emmanouil; Puckett, Lindsay; Tai, Melissa F.; Stewart, Cameron R.; Hickman, Suzanne E.; Moore, Kathryn J.; El Khoury, Joseph; Means, Terry K.; Mylonakis, Eleftherios; Colvin, Richard Anthony; Seung, Edward N.; Pukkila-Worley, Read; Calderwood, Stephen Beaven; Hacohen, Nir; Luster, Andrew David (Rockefeller University Press, 2009)
      Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 ...
    • HIV-infected T cells are migratory vehicles for viral dissemination 

      Murooka, Thomas; Deruaz, Maud; Marangoni, Francesco; Vrbanac, Vladimir; Seung, Edward N.; Von Andrian, Ulrich H.; Tager, Andrew Martin; Luster, Andrew David; Mempel, Thorsten Roman (2012)
      After host entry through mucosal surfaces, HIV-1 disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally ...
    • Neutralizing Anti-HIV Antibodies Develop in a Humanized Mouse Model of HIV-1 Infection 

      Vrbanac, Vladimir; Tivey, T; Cariappa, A; Seung, Edward N.; Dugast, Anne-Sophie; Dudek, Timothy E; Mattoo, Hamid Rasheed; Murooka, Thomas; Pillai, Shiv Subramaniam; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)
    • PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads 

      Seung, Edward; Dudek, Timothy E.; Allen, Todd M.; Freeman, Gordon J.; Luster, Andrew D.; Tager, Andrew M. (Public Library of Science, 2013)
      An estimated 34 million people are living with HIV worldwide (UNAIDS, 2012), with the number of infected persons rising every year. Increases in HIV prevalence have resulted not only from new infections, but also from ...
    • Rapid Evolution of HIV-1 to Functional CD8+ T-cell rResponses in Humanized BLT Mice 

      Dudek, TE; No, DC; Vrbanac, Vladimir; Fadda, L; Bryant, KF; Luster, AD; Knipe, DM; Tager, AM; Allen, TM; Seung, Edward N.; Altfeld, Marcus (BioMed Central, 2012)
    • TLR7/9 Antagonist Reduces HIV-1-Induced Immune Activation 

      Chang, Ju-Hui; Lindsay, RJ; Doyle, EH; Vrbanac, Vladimir; Seung, Edward N.; Dudek, Timothy E; Bosch, Ronald J.; Precopio, M; Kandimalla, E; Tager, Andrew Martin; Altfeld, Marcus (BioMed Central, 2012)