Browsing by Author "Wu, C.-ting"
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Abnormal Dosage of Ultraconserved Elements Is Highly Disfavored in Healthy Cells but Not Cancer Cells
McCole, Ruth B.; Fonseka, Chamith Y.; Koren, Amnon; Wu, C.-ting (Public Library of Science, 2014)Ultraconserved elements (UCEs) are strongly depleted from segmental duplications and copy number variations (CNVs) in the human genome, suggesting that deletion or duplication of a UCE can be deleterious to the mammalian ... -
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
Savova, Virginia; Chun, Sung; Sohail, Mashaal; McCole, Ruth B.; Witwicki, Robert; Gai, Lisa; Lenz, Tobias L.; Wu, C.-ting; Sunyaev, Shamil R.; Gimelbrant, Alexander A. (2016)An unexpectedly large number of human autosomal genes are subject to monoallelic expression (MAE). Our analysis of 4,227 such genes reveals surprisingly high genetic variation across human populations. This increased ... -
Identification of Genes That Promote or Antagonize Somatic Homolog Pairing Using a High-Throughput FISH–Based Screen
Joyce, Eric; Williams, Benjamin R.; Xie, Tiao; Wu, C.-ting (Public Library of Science, 2012)The pairing of homologous chromosomes is a fundamental feature of the meiotic cell. In addition, a number of species exhibit homolog pairing in nonmeiotic, somatic cells as well, with evidence for its impact on both gene ...