Browsing by Author "Chibnik, Lori"

Now showing items 1-18 of 18

    • 24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex 

      Lim, Andrew S. P.; Srivastava, Gyan P.; Yu, Lei; Chibnik, Lori B.; Xu, Jishu; Buchman, Aron S.; Schneider, Julie A.; Myers, Amanda J.; Bennett, David A.; De Jager, Philip L. (Public Library of Science, 2014)
      Circadian rhythms modulate the biology of many human tissues, including brain tissues, and are driven by a near 24-hour transcriptional feedback loop. These rhythms are paralleled by 24-hour rhythms of large portions of ...

    • Alzheimer’s loci: epigenetic associations and interaction with genetic factors 

      Chibnik, Lori B; Yu, Lei; Eaton, Matthew L; Srivastava, Gyan; Schneider, Julie A; Kellis, Manolis; Bennett, David A; De Jager, Philip L (John Wiley & Sons, Ltd, 2015)
      Objective: We explore the role of DNA methylation in Alzheimer’s disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role ...

    • CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology 

      Bradshaw, Elizabeth M; Chibnik, Lori B; Keenan, Brendan T; Ottoboni, Linda; Raj, Towfique; Tang, Anna; Rosenkrantz, Laura L; Imboywa, Selina; Lee, Michelle; Von Korff, Alina; Morris, Martha C; Evans, Denis A; Johnson, Keith; Sperling, Reisa A; Schneider, Julie A; Bennett, David A; De Jager, Philip L (2013)
      In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) ...

    • Common variants at 12q14 and 12q24 are associated with hippocampal volume 

      Bis, Joshua C.; DeCarli, Charles; Smith, Albert Vernon; van der Lijn, Fedde; Crivello, Fabrice; Fornage, Myriam; Debette, Stephanie; Shulman, Joshua M.; Schmidt, Helena; Srikanth, Velandai; Schuur, Maaike; Yu, Lei; Choi, Seung-Hoan; Sigurdsson, Sigurdur; Verhaaren, Benjamin F.J.; DeStefano, Anita L.; Lambert, Jean-Charles; Jack, Clifford R.; Struchalin, Maksim; Stankovich, Jim; Ibrahim-Verbaas, Carla A.; Fleischman, Debra; Zijdenbos, Alex; den Heijer, Tom; Mazoyer, Bernard; Coker, Laura H.; Enzinger, Christian; Danoy, Patrick; Amin, Najaf; Arfanakis, Konstantinos; van Buchem, Mark A.; de Bruijn, Renée F.A.G.; Beiser, Alexa; Dufouil, Carole; Huang, Juebin; Cavalieri, Margherita; Thomson, Russell; Niessen, Wiro J.; Chibnik, Lori B.; Gislason, Gauti K.; Hofman, Albert; Pikula, Aleksandra; Amouyel, Philippe; Freeman, Kevin B.; Phan, Thanh G.; Oostra, Ben A.; Stein, Jason L.; Medland, Sarah E.; Vasquez, Alejandro Arias; Hibar, Derrek P.; Wright, Margaret J.; Franke, Barbara; Martin, Nicholas G.; Thompson, Paul M.; Nalls, Michael A.; Uitterlinden, Andre G.; Au, Rhoda; Elbaz, Alexis; Beare, Richard J.; van Swieten, John C.; Lopez, Oscar; Harris, Tamara B.; Chouraki, Vincent; Breteler, Monique M.B.; De Jager, Philip L.; Becker, James T.; Vernooij, Meike W.; Knopman, David; Fazekas, Franz; Wolf, Philip A.; van der Lugt, Aad; Gudnason, Vilmundur; Longstreth, W.T.; Brown, Mathew A.; Bennett, David A.; van Duijn, Cornelia M.; Mosley, Thomas H.; Schmidt, Reinhold; Tzourio, Christophe; Launer, Lenore J.; Ikram, M. Arfan; Seshadri, Sudha (2012)
      Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs ...

    • Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset 

      Bove, Riley; Chua, Alicia S.; Xia, Zongqi; Chibnik, Lori; De Jager, Philip L.; Chitnis, Tanuja (Wolters Kluwer, 2016)
      Objective: To examine the relationship between 2 markers of early multiple sclerosis (MS) onset, 1 genetic (HLA-DRB1*1501) and 1 experiential (early menarche), in 2 cohorts. Methods: We included 540 white women with MS or ...

    • Genes and Environment in Multiple Sclerosis Project: A Platform to Investigate Multiple Sclerosis Risk 

      Xia, Zongqi; White, Charles C.; Owen, Emily K.; Von Korff, Alina; Clarkson, Sarah R.; McCabe, Cristin; Cimpean, Maria; Winn, Phoebe A.; Hoesing, Ashley; Steele, Sonya U.; Cortese, Irene C. M.; Chitnis, Tanuja; Weiner, Howard; Reich, Daniel S.; Chibnik, Lori; De Jager, Philip (Wiley, 2016-02)
      The Genes and Environment in Multiple Sclerosis (GEMS) project establishes a platform to investigate the events leading to MS in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using ...

    • Genetic architecture of age-related cognitive decline in African Americans 

      Raj, Towfique; Chibnik, Lori B.; McCabe, Cristin; Wong, Andus; Replogle, Joseph M.; Yu, Lei; Gao, Sujuan; Unverzagt, Frederick W.; Stranger, Barbara; Murrell, Jill; Barnes, Lisa; Hendrie, Hugh C.; Foroud, Tatiana; Krichevsky, Anna; Bennett, David A.; Hall, Kathleen S.; Evans, Denis A.; De Jager, Philip L. (Wolters Kluwer, 2016)
      Objective: To identify genetic risk factors associated with susceptibility to age-related cognitive decline in African Americans (AAs). Methods: We performed a genome-wide association study (GWAS) and an admixture-mapping ...

    • A High-Dimensional Immune Monitoring Model of HIV-1-Specific CD8 T Cell Responses Accurately Identifies Subjects Achieving Spontaneous Viral Control 

      Proudfoot, J; Vine, S; Cesa, K; Piechocka-Trocha, A; Ndhlovu, Zaza Mtine; Chibnik, Lori; McMullen, A; Porichis, Filippos; Alvino, Donna Marie Lucia; De Jager, Philip Lawrence; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2012)

    • Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers 

      Palmer, Christine D; Romero-Tejeda, Marisol; Scully, Eileen P; Lockhart, Ainsley; Seaman, Michael S; Goldenthal, Ariel; Piechocka-Trocha, Alicja; Walker, Bruce D; Chibnik, Lori B; Jost, Stephanie; Porichis, Filippos (International AIDS Society, 2016)
      Introduction: An effective prophylactic vaccine against HIV will need to elicit antibody responses capable of recognizing and neutralizing rapidly evolving antigenic regions. The immunologic milieu associated with development ...

    • Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease 

      Shulman, Joshua Marc; Chibnik, Lori; Aubin, Cristin; Schneider, Julie A.; Bennett, David A.; De Jager, Philip Lawrence (Public Library of Science, 2010)
      Background: Recent genetic studies have identified a growing number of loci with suggestive evidence of association with susceptibility to Alzheimer's disease (AD). However, little is known of the role of these candidate ...

    • Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records 

      Xia, Zongqi; Secor, Elizabeth; Chibnik, Lori B.; Bove, Riley M.; Cheng, Suchun; Chitnis, Tanuja; Cagan, Andrew; Gainer, Vivian S.; Chen, Pei J.; Liao, Katherine P.; Shaw, Stanley Y.; Ananthakrishnan, Ashwin N.; Szolovits, Peter; Weiner, Howard L.; Karlson, Elizabeth W.; Murphy, Shawn N.; Savova, Guergana K.; Cai, Tianxi; Churchill, Susanne E.; Plenge, Robert M.; Kohane, Isaac S.; De Jager, Philip L. (Public Library of Science, 2013)
      Objective: To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract ...

    • Modeling the Cumulative Genetic Risk for Multiple Sclerosis from Genome-Wide Association Data 

      Wang, Joanne H; Pappas, Derek; Pelletier, Daniel; Kappos, Ludwig; Polman, Chris H; Matthews, Paul M; Hauser, Stephen L; Baranzini, Sergio E; Oksenberg, Jorge R; De Jager, Philip Lawrence; de Bakker, Paul I Wen; Chibnik, Lori; Hafler, David A. (BioMed Central, 2011)
      Background: Multiple sclerosis (MS) is the most common cause of chronic neurologic disability beginning in early to middle adult life. Results from recent genome-wide association studies (GWAS) have substantially lengthened ...

    • Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes 

      Chan, Gail; White, Charles C.; Winn, Phoebe A.; Cimpean, Maria; Replogle, Joseph M.; Glick, Laura R.; Cuerdon, Nicole E.; Ryan, Katie J.; Johnson, Keith A.; Schneider, Julie A.; Bennett, David A.; Chibnik, Lori B.; Sperling, Reisa A.; Bradshaw, Elizabeth M.; De Jager, Philip L. (2015)
      Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele ...

    • A Prospective Study of Androgen Levels, Hormone-related Genes and Risk of Rheumatoid Arthritis 

      McGrath, Monica; Keenan, Brendan T; Karlson, Elizabeth Wood; Chibnik, Lori; Chang, Shun-Chiao; Costenbader, Karen Harte; Fraser, Patricia Ann; Tworoger, Shelley Slate; Tworoger, Shelley Slate; Hankinson, Susan Elizabeth; Lee, I-Min; Buring, Julie Elizabeth; De Vivo, Immaculata (BioMed Central, 2009)
      Introduction: Rheumatoid arthritis (RA) is more common in females than males and sex steroid hormones may in part explain this difference. We conducted a case–control study nested within two prospective studies to determine ...

    • The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers 

      Benitez, Bruno A.; Karch, Celeste M.; Cai, Yefei; Jin, Sheng Chih; Cooper, Breanna; Carrell, David; Bertelsen, Sarah; Chibnik, Lori; Schneider, Julie A.; Bennett, David A.; Fagan, Anne M.; Holtzman, David; Morris, John C.; Goate, Alison M.; Cruchaga, Carlos (Public Library of Science, 2013)
      The primary constituents of plaques (Aβ42/Aβ40) and neurofibrillary tangles (tau and phosphorylated forms of tau [ptau]) are the current leading diagnostic and prognostic cerebrospinal fluid (CSF) biomarkers for AD. In ...

    • A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis 

      Xia, Zongqi; Chibnik, Lori; Glanz, Bonnie; Liguori, Maria; Shulman, Joshua M.; Tran, Dong; Khoury, Samia; Chitnis, Tanuja; Holyoak, Todd; Weiner, Howard; Guttmann, Charles; De Jager, Philip L. (Public Library of Science (PLoS), 2010-11-30)
      Background Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset ...

    • A randomized controlled trial of an intervention to reduce low literacy barriers in inflammatory arthritis management 

      Rudd, Rima E.; Blanch, Danielle C.; Gall, Victoria; Chibnik, Lori; Wright, Elizabeth A; Reichmann, William; Liang, Matthew Heng; Katz, Jeffrey Neil (Elsevier BV, 2009)
      Objective Test the efficacy of educational interventions to reduce literacy barriers and enhance health outcomes among patients with inflammatory arthritis. Methods The intervention consisted of plain language ...

    • Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci 

      Chan, Gail; White, Charles C.; Winn, Phoebe A.; Cimpean, Maria; Replogle, Joseph M.; Glick, Laura R.; Cuerdon, Nicole E.; Ryan, Katie J.; Johnson, Keith A.; Schneider, Julie A.; Bennett, David A.; Chibnik, Lori B.; Sperling, Reisa A.; De Jager, Philip L.; Bradshaw, Elizabeth M. (Wolters Kluwer, 2016)
      Objective: Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility ...