Browsing by Author "Cosimi, A."

Now showing items 1-5 of 5

    • Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts 

      Farris, A.B.; Taheri, D.; Kawai, Tatsuo; Fazlollahi, L.; Wong, Wesley Philip; Tolkoff-Rubin, Nina Ellen; Spitzer, Thomas Richard; Iafrate, Anthony John; Preffer, Frederic Ira; LoCascio, S. A.; Sprangers, B.; Saidman, Susan L.; Smith, Raymond Malcolm; Cosimi, A. Benedict; Sykes, Megan; Sachs, David H.; Colvin, Robert Barnes (Wiley-Blackwell, 2011)
      An idiopathic capillary leak syndrome (“engraftment syndrome”) often occurs in recipients of hematopoietic cells, manifested clinically by transient azotemia and sometimes fever and fluid retention. Here we report the renal ...

    • HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression 

      Kawai, Tatsuo; Cosimi, A. Benedict; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Suthanthiran, Manikkam; Saidman, Susan L.; Shaffer, Juanita; Preffer, Frederic Ira; Ding, Ruchuang; Sharma, Vijay; Fishman, Jay Alan; Dey, Bimalangshu; Ko, Dicken S.C.; Hertl, Martin; Goes, Nelson B.; Wong, Waichi; Williams, Winfred Woodrow; Colvin, Robert Barnes; Sykes, Megan; Sachs, David H. (New England Journal of Medicine (NEJM/MMS), 2008)
      Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient ...

    • Live Donor Partial Hepatectomy for Liver Transplantation: Is There a Learning Curve? 

      Saidi, R. F.; Elias, N.; Ko, D. S.; Kawai, T.; Markmann, J.; Feng, S.; Cosimi, A. B.; Hertl, M. (Avicenna Organ Transplantation Institute, 2010)
      Background: Donor safety is the first priority in living donor liver transplantation (LDLT). Objective: To determine the characteristics and outcome of live liver donors who underwent donor hepatectomy from January, 1997 ...

    • Mixed Chimerism, Lymphocyte Recovery, and Evidence for Early Donor-Specific Unresponsiveness in Patients Receiving Combined Kidney and Bone Marrow Transplantation to Induce Tolerance 

      LoCascio, Samuel A.; Morokata, Tatsuaki; Chittenden, Meredith; Preffer, Frederic Ira; Dombkowski, David M.; Andreola, Giovanna; Crisalli, Kerry; Kawai, Tatsuo; Saidman, Susan L.; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Cosimi, A. Benedict; Sachs, David H.; Sykes, Megan (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background We have previously reported operational tolerance in patients receiving HLA-mismatched combined kidney and bone marrow transplantation (CKBMT). We now report on transient multilineage hematopoietic chimerism ...

    • Tolerance Induction after Organ Transplantation, “Delayed Tolerance,” Via the Mixed Chimerism Approach: Planting Flowers in a Battle Field 

      Yamada, Yohei; Benichou, Gilles A.; Cosimi, A. Benedict; Kawai, Tatsuo (Landes Bioscience, 2012)
      We have previously reported that peri-transplant conditioning leads to successful induction of renal allograft tolerance via the mixed chimerism approach in nonhuman primates (NHP) and humans. However, this strategy requires ...