Browsing by Author "Pagliuca, Felicia"

Now showing items 1-3 of 3

    • Charting Cellular Identity During Human in Vitro β-Cell Differentiation 

      Veres, Adrian; Faust, Aubrey; Bushnell, Henry; Engquist, Elise; Kenty, Jennifer; Harb, George; Poh, Yeh-Chuin; Sintov, Elad; Gürtler, Mads; Pagliuca, Felicia; Peterson, Quinn; Melton, Douglas (Springer Science and Business Media LLC, 2019-05)
      In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding this differentiation process, we ...

    • How to make a functional β-cell 

      Pagliuca, Felicia Jane; Melton, Douglas A. (The Company of Biologists, 2013)
      Insulin-secreting pancreatic β-cells are essential regulators of mammalian metabolism. The absence of functional β-cells leads to hyperglycemia and diabetes, making patients dependent on exogenously supplied insulin. Recent ...

    • A simple tool to improve pluripotent stem cell differentiation 

      Chetty, Sundari; Pagliuca, Felicia Jane; Honore, Christian; Kweudjeu, Anastasie; Rezania, Alireza; Melton, Douglas A. (Nature Publishing Group, 2013)
      We describe a method to help overcome restrictions on the differentiation propensities of human pluripotent stem cells. Culturing pluripotent stem cells in dimethylsulfoxide (DMSO) activates the retinoblastoma protein, ...