Now showing items 1-2 of 2

    • Sialylation of Immunoglobulin E Is a Determinant of Allergic Pathogenicity 

      Shade, Kai-Ting; Conroy, Michelle; Washburn, Nathaniel; Kitaoka, Maya; Huynh, Daniel; Laprise, Emma; Patil, Sarita U.; Shreffler, Wayne; Anthony, Robert M.; Anthony, R (Springer Science and Business Media LLC, 2020-05-20)
      Approximately one-third of the world’s population suffers from allergies1. Allergen exposure crosslinks mast cell- and basophil-bound immunoglobulin E (IgE), triggering the release of inflammatory mediators, including ...
    • A single glycan on IgE is indispensable for initiation of anaphylaxis 

      Shade, Kai-Ting C.; Platzer, Barbara; Washburn, Nathaniel; Mani, Vinidhra; Bartsch, Yannic C.; Conroy, Michelle; Pagan, Jose D.; Bosques, Carlos; Mempel, Thorsten R.; Fiebiger, Edda; Anthony, Robert M. (The Rockefeller University Press, 2015)
      Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental antigens, or allergens, binds and sensitizes ...