Now showing items 1-10 of 10

    • Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics 

      Rolland, Morgane; Manocheewa, Siriphan; Lanxon-Cookson, Erinn; Deng, Wenjie; Rousseau, Christine M.; Raugi, Dana N.; Learn, Gerald H.; Maust, Brandon S.; Coovadia, Hoosen; Ndung'u, Thumbi; Heckerman, David E.; Mullins, James I.; Carlson, Jonathan Courtland; Swain, Jabaris; Goulder, Philip J.; Walker, Bruce David; Brander, Christian (Public Library of Science, 2010)
      Background: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the ...
    • Broad and Gag-Biased HIV-1 Epitope Repertoires are Associated with Lower Viral Loads 

      Rolland, Morgane; Heckerman, David; Deng, Wenjie; Rousseau, Christine M.; Coovadia, Hoosen; Bishop, Karen; Goulder, Philip J.; Walker, Bruce David; Brander, Christian; Mullins, James I. (Public Library of Science, 2008)
      Background: HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) ...
    • Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1 

      Brumme, Zabrina L; Brumme, Chanson J; Heckerman, David; Korber, Bette T; Daniels, Marcus; Kadie, Carl; Bhattacharya, Tanmoy; Chui, Celia; Szinger, James; Mo, Theresa; Hogg, Robert S; Montaner, Julio S. G; Frahm, Nicole; Harrigan, P. Richard; Carlson, Jonathan Courtland; Brander, Christian; Walker, Bruce David (Public Library of Science, 2007)
      Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based ...
    • HLA Class I Supertypes: A Revised and Updated Classification 

      Sidney, John; Peters, Bjoern; Frahm, Nicole; Brander, Christian; Sette, Alessandro (BioMed Central, 2008)
      Background: Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a ...
    • Immune-Driven Recombination and Loss of Control after HIV Superinfection 

      Streeck, Hendrik; Li, Bin; Poon, Art F. Y.; Schneidewind, Anne; Gladden, Adrianne D.; Power, Karen A.; Daskalakis, Demetre; Bazner, Suzane; Zuniga, Rosario; Brander, Christian; Rosenberg, Eric Scott; Frost, Simon D. W.; Altfeld, Marcus; Allen, Todd (The Rockefeller University Press, 2008)
      After acute HIV infection, CD8^{+} T cells are able to control viral replication to a set point. This control is often lost after superinfection, although the mechanism behind this remains unclear. In this study, we ...
    • Lost in Translation: Obstacles to Translational Medicine 

      Mankoff, Stacey P.; Brander, Christian; Ferrone, Soldano; Marincola, Francesco M. (BioMed Central, 2004)
      When we launched the Journal of Translational Medicine a few months ago, we were interested primarily in exploring scientific consideration of this discipline. However, as editors of JTM, we have been contacted almost daily ...
    • Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins 

      Rolland, Morgane; Nickle, David C.; Deng, Wenjie; Frahm, Nicole; Learn, Gerald H.; Heckerman, David; Jojic, Nebosja; Jojic, Vladimir; Mullins, James I.; Brander, Christian; Walker, Bruce David (Public Library of Science, 2007)
      Background: While human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes preferentially target specific regions of the viral proteome, HIV-1 features that contribute to immune recognition are not well ...
    • Rewarding Patient-Directed Research: Excellence in Translational Medicine Award 

      Brander, Christian; Ferrone, Soldano; Marincola, Francesco M (BioMed Central, 2006)
      The Editorial Board of Journal of Translational Medicine is pleased to announce a prize to recognize outstanding contributions in the field of translational medicine. The prize is sponsored by Pfizer Global Research and ...
    • Simultaneous Assessment of Cytotoxic T Lymphocyte Responses Against Multiple Viral Infections by Combined Usage of Optimal Epitope Matrices, Anti- CD3 mAb T-cell Expansion and "RecycleSpot" 

      Bihl, Florian K; Loggi, Elisabetta; Chisholm, John V; Hewitt, Hannah S; Henry, Leah M; Suscovich, Todd J; Frahm, Nicole; Andreone, Pietro; Linde, Caitlyn; Wong, Johnson Tai; Brander, Christian (BioMed Central, 2005)
      The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses against multiple ...
    • Transfusion-Transmitted Infections 

      Bihl, Florian; Castelli, Damiano; Marincola, Francesco; Dodd, Roger Y; Brander, Christian (BioMed Central, 2007)
      Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens. Only continuous ...