Now showing items 1-20 of 22

    • 3D Ultrasound-Guided Motion Compensation System for Beating Heart Mitral Valve Repair 

      Yuen, Shelten G.; Kesner, Samuel Benjamin; Vasilyev, Nikolay; Del Nido, Pedro J.; Howe, Robert D. (Springer Verlag, 2008)
      Beating heart intracardiac procedures promise significant benefits for patients, however, the fast motion of the heart poses serious challenges to surgeons. We present a new 3D ultrasound-guided motion (3DUS) compensation ...
    • Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function 

      Pacak, Christina A.; Preble, Janine M.; Kondo, Hiroshi; Seibel, Peter; Levitsky, Sidney; del Nido, Pedro J.; Cowan, Douglas B.; McCully, James D. (The Company of Biologists, 2015)
      Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by ...
    • Anisotropic Mass-Spring Method Accurately Simulates Mitral Valve Closure from Image-Based Models 

      Hammer, Peter; Del Nido, Pedro J.; Howe, Robert D. (Springer Science + Business Media, 2011)
      Heart valves are functionally complex, making surgical repair difficult. Simulation-based surgical planning could facilitate repair, but current finite element studies are prohibitively slow for rapid, clinically-oriented ...
    • Concentric Tube Robot Design and Optimization Based on Task and Anatomical Constraints 

      Bergeles, Christos; Gosline, Andrew H.; Vasilyev, Nikolay; Codd, Patrick J.; Del Nido, Pedro J.; Dupont, Pierre E (Institute of Electrical and Electronics Engineers (IEEE), 2015)
      Concentric tube robots are catheter-sized continuum robots that are well suited for minimally invasive surgery inside confined body cavities. These robots are constructed from sets of pre-curved superelastic tubes and are ...
    • Distention of the Immature Left Ventricle Triggers Development of Endocardial Fibroelastosis: An Animal Model of Endocardial Fibroelastosis Introducing Morphopathological Features of Evolving Fetal Hypoplastic Left Heart Syndrome 

      Shimada, Shogo; Robles, Christian; Illigens, Ben M. W.; Casar Berazaluce, Alejandra M.; del Nido, Pedro J.; Friehs, Ingeborg (Hindawi Publishing Corporation, 2015)
      Background. Endocardial fibroelastosis (EFE), characterized by a diffuse endocardial thickening through collagen and elastin fibers, develops in the human fetal heart restricting growth of the left ventricle (LV). Recent ...
    • Fast Image-Based Model of Mitral Valve Closure for Surgical Planning 

      Hammer, Peter E.; Vasilyev, Nikolay V.; Perrin, Douglas P.; Del Nido, Pedro J.; Howe, Robert D. (MIDAS, 2008)
      Surgical repair of the mitral valve results in better outcomes than valve replacement, yet diseased valves are often replaced due to the technical difficulty of the repair process. A surgical planning system based ...
    • Force tracking with feed-forward motion estimation for beating heart surgery 

      Yuen, Shelten G.; Perrin, Douglas Paul; Vasilyev, Nikolay; Del Nido, Pedro J.; Howe, Robert D. (Institute of Electrical & Electronics Engineers (IEEE), 2010)
      The manipulation of fast moving, delicate tissues in beating heart procedures presents a considerable challenge to the surgeon. A robotic force tracking system can assist the surgeon by applying precise contact forces to ...
    • Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection 

      Cowan, Douglas B.; Yao, Rouan; Akurathi, Vamsidhar; Snay, Erin R.; Thedsanamoorthy, Jerusha K.; Zurakowski, David; Ericsson, Maria; Friehs, Ingeborg; Wu, Yaotang; Levitsky, Sidney; del Nido, Pedro J.; Packard, Alan B.; McCully, James D. (Public Library of Science, 2016)
      We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile ...
    • Mass-Spring Model for Simulation of Heart Valve Tissue Mechanical Behavior 

      Hammer, Peter; Sacks, Michael S.; Del Nido, Pedro J.; Howe, Robert D. (Springer Nature, 2011)
      Heart valves are functionally complex, making surgical repair difficult. Simulation-based surgical planning could facilitate repair, but current finite element (FE) studies are prohibitively slow for rapid, clinically ...
    • Metal MEMS tools for beating-heart tissue approximation 

      Butler, Evan J.; Folk, Chris; Cohen, Adam; Vasilyev, Nikolay; Chen, Rich; Del Nido, Pedro J.; Dupont, Pierre E (IEEE, 2011)
      Achieving superior outcomes through the use of robots in medical applications requires an integrated approach to the design of the robot, tooling and the procedure itself. In this paper, this approach is applied to develop ...
    • Mitochondrial transplantation for therapeutic use 

      McCully, James Donald; Levitsky, Sidney; Del Nido, Pedro J.; Cowan, Douglas Burr (Springer Science + Business Media, 2016)
      Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obstruction of ...
    • Mitral Annulus Segmentation From Three-Dimensional Ultrasound 

      Schneider, Robert Joseph; Perrin, Douglas Paul; Vasilyev, Nikolay; Marx, Gerald Ross; Del Nido, Pedro J.; Howe, Robert D. (Institute of Electrical and Electronics Engineers, 2009)
      An accurate and reproducible segmentation of the mitral valve annulus from 3D ultrasound is useful to clinicians and researchers in applications such as pathology diagnosis and mitral valve modeling. Current segmentation ...
    • Modeling Mitral Valve Leaflets from Three-Dimensional Ultrasound 

      Howe, Robert D.; Schneider, Robert J.; Burke, William Conroy; Marx, Gerald Ross; Del Nido, Pedro J. (Springer Science + Business Media, 2011)
      The geometry of the mitral leaflets, most commonly viewed using three-dimensional ultrasound, is an important input for mechanical models predicting valve closure. Current methods for leaflet modeling from ultrasound either ...
    • Myocardial Hypertrophy Overrides the Angiogenic Response to Hypoxia 

      Choi, Yeong-Hoon; Poutias, Dimitrios; Stamm, Christof; Cowan, Douglas Burr; Nathan, Meena; Del Nido, Pedro J.; McGowan, Francis Xavier (Public Library of Science, 2008)
      Background: Cyanosis and myocardial hypertrophy frequently occur in combination. Hypoxia or cyanosis can be potent inducers of angiogenesis, regulating the expression of hypoxia-inducible factors (HIF), vascular endothelial ...
    • Neonatal Mitral Valve Repair in Biventricular Repair, Single Ventricle Palliation, and Secondary Left Ventricular Recruitment: Indications, Techniques, and Mid-Term Outcomes 

      Myers, Patrick O.; Baird, Christopher W.; del Nido, Pedro J.; Pigula, Frank A.; Lang, Nora; Marx, Gerald R.; Emani, Sitaram M. (Frontiers Media S.A., 2015)
      Objectives: Although mitral valve repair is rarely required in neonates, this population is considered to be at high risk for adverse outcomes. The aim of this study was to review the indications for surgery, mechanisms, ...
    • Patient-Specific Mitral Leaflet Segmentation from 4D Ultrasound 

      Tenenholtz, Neil Arturo; Perrin, Douglas Paul; Marx, Gerald Ross; Del Nido, Pedro J.; Schneider, Robert J.; Howe, Robert D. (Springer, 2011)
      Segmenting the mitral valve during closure and throughout a cardiac cycle from four dimensional ultrasound (4DUS) is important for creation and validation of mechanical models and for improved visualization and understanding ...
    • Patient-Specific MRI-Based Right Ventricle Models Using Different Zero-Load Diastole and Systole Geometries for Better Cardiac Stress and Strain Calculations and Pulmonary Valve Replacement Surgical Outcome Predictions 

      Tang, Dalin; del Nido, Pedro J.; Yang, Chun; Zuo, Heng; Huang, Xueying; Rathod, Rahul H.; Gooty, Vasu; Tang, Alexander; Wu, Zheyang; Billiar, Kristen L.; Geva, Tal (Public Library of Science, 2016)
      Background: Accurate calculation of ventricular stress and strain is critical for cardiovascular investigations. Sarcomere shortening in active contraction leads to change of ventricular zero-stress configurations during ...
    • Percutaneous intracardiac beating-heart surgery using metal MEMS tissue approximation tools 

      Gosline, Andrew H; Vasilyev, Nikolay; Butler, Evan J; Folk, Chris; Cohen, Adam; Chen, Rich; Lang, Nora; Del Nido, Pedro J.; Dupont, Pierre E (SAGE Publications, 2012)
      Achieving superior outcomes through the use of robots in medical applications requires an integrated approach to the design of the robot, tooling and the procedure itself. In this paper, this approach is applied to develop ...
    • Robotic Force Stabilization for Beating Heart Intracardiac Surgery 

      Yuen, Shelten G.; Yip, Michael C.; Vasilyev, Nikolay; Perrin, Douglas Paul; Del Nido, Pedro J.; Howe, Robert D. (Springer Verlag, 2009)
      The manipulation of fast moving, delicate tissues in beating heart procedures presents a considerable challenge to surgeons. We present a new robotic force stabilization system that assists surgeons by maintaining a constant ...
    • Robotic tissue tracking for beating heart mitral valve surgery 

      Yuen, Shelten G.; Vasilyev, Nikolay; Del Nido, Pedro J.; Howe, Robert D. (Elsevier BV, 2013)
      The rapid motion of the heart presents a significant challenge to the surgeon during intracardiac beating heart procedures. We present a 3D ultrasound-guided motion compensation system that assists the surgeon by synchronizing ...