Now showing items 1-7 of 7

    • Comparative Proteomic Analysis of the PhoP Regulon in Salmonella enterica Serovar Typhi Versus Typhimurium 

      Lebrun, Lauren M.; Sheikh, Alaullah; Logvinenko, Tanya; Tarique, Abdullah; Krastins, Bryan; Qadri, Firdausi; Charles, Richelle Candice; Harris, Jason B.; Chase, Michael Richard; Larocque, Regina Celes; Rollins, Sean McKenzie; Hohmann, Elizabeth Louise; Rosenberg, Ian Morley; Sarracino, David A.; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2009)
      Background: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic ...
    • DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader 

      Rock, Jeremy M.; Lang, Ulla F.; Chase, Michael R.; Ford, Christopher B.; Gerrick, Elias R.; Gawande, Richa; Coscolla, Mireia; Gagneux, Sebastien; Fortune, Sarah M.; Lamers, Meindert H. (2015)
      The DNA replication machinery is an important target for antibiotic development for increasingly drug resistant bacteria including Mycobacterium tuberculosis1. While blocking DNA replication leads to cell death, disrupting ...
    • EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity 

      Garces, Alejandra; Woodworth, Joshua S.; Krastins, Bryan; Atmakuri, Krishnamohan; Chase, Michael Richard; Rothchild, Alissa C.; Ramsdell, Talia Lynn; Lopez, Mary Frances; Behar, Samuel M; Sarracino, David A.; Fortune, Sarah Merritt (Public Library of Science, 2010)
      Mycobacterium tuberculosis (Mtb) requires the ESX1 specialized protein secretion system for virulence, for triggering cytosolic immune surveillance pathways, and for priming an optimal CD8+ T cell response. This suggests ...
    • The ESX System in Bacillus subtilis Mediates Protein Secretion 

      Huppert, Laura A.; Ramsdell, Talia L.; Chase, Michael R.; Sarracino, David A.; Fortune, Sarah M.; Burton, Briana M. (Public Library of Science, 2014)
      Esat-6 protein secretion systems (ESX or Ess) are required for the virulence of several human pathogens, most notably Mycobacterium tuberculosis and Staphylococcus aureus. These secretion systems are defined by a conserved ...
    • The Genome and Structural Proteome of an Ocean Siphovirus: A New Window into the Cyanobacterial ‘Mobilome’ 

      Sullivan, Matthew; Krastins, Bryan; Hughes, Jennifer L; Kelly, Libusha; Chase, Michael Richard; Sarracino, David A.; Chisholm, Sallie W (Blackwell Publishing, 2009)
      Prochlorococcus, an abundant phototroph in the oceans, are infected by members of three families of viruses: myo-, podo- and siphoviruses. Genomes of myo- and podoviruses isolated on Prochlorococcus contain DNA replication ...
    • Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape 

      Shell, Scarlet S.; Wang, Jing; Lapierre, Pascal; Mir, Mushtaq; Chase, Michael R.; Pyle, Margaret M.; Gawande, Richa; Ahmad, Rushdy; Sarracino, David A.; Ioerger, Thomas R.; Fortune, Sarah M.; Derbyshire, Keith M.; Wade, Joseph T.; Gray, Todd A. (Public Library of Science, 2015)
      RNA-seq technologies have provided significant insight into the transcription networks of mycobacteria. However, such studies provide no definitive information on the translational landscape. Here, we use a combination of ...
    • The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection 

      Ragheb, Mark N; Ford, Christopher Burton; Chase, Michael Richard; Lin, Philana Ling; Flynn, JoAnne L; Fortune, Sarah Merritt (BioMed Central, 2013)
      Background: Mycobacterial interspersed repetitive units (MIRUs) are minisatellites within the Mycobacterium tuberculosis (Mtb) genome. Copy number variation (CNV) in MIRU loci is used for epidemiological typing, making the ...