Now showing items 1-20 of 212

    • A 3D-printed, functionally graded soft robot powered by combustion 

      Bartlett, Nicholas Warren; Tolley, M. T.; Overvelde, Johannes Tesse bastiaan; Weaver, J; Mosadegh, B; Bertoldi, Katia; Whitesides, George McClelland; Wood, Robert J. (American Association for the Advancement of Science (AAAS), 2015)
      Roboticists have begun to design biologically inspired robots with soft or partially soft bodies, which have the potential to be more robust and adaptable, and safer for human interaction, than traditional rigid robots. ...
    • AC Electric Fields Drive Steady Flows in Flames 

      Drews, Aaron M.; Cademartiri, Ludovico; Chemama, Michael Leopold; Brenner, Michael P.; Whitesides, George M.; Bishop, Kyle J. M. (American Physical Society (APS), 2012)
      We show that time-oscillating electric fields applied to plasmas present in flames create steady flows of gas. Ions generated within the flame move in the field and migrate a distance δ before recombining; the net flow of ...
    • Acetylation of Surface Lysine Groups of a Protein Alters the Organization and Composition of Its Crystal Contacts 

      Kang, Kyungtae; Choi, Jeong-Mo; Fox, Jerome M.; Snyder, Phillip W.; Moustakas, Demetri T.; Whitesides, George McClelland (American Chemical Society (ACS), 2016)
      This paper uses crystals of bovine carbonic anhydrase (CA) and its acetylated variant to examine (i) how a large negative formal charge can be accommodated in protein-protein interfaces, (ii) why lysine residues are often ...
    • Adaptive Use of Bubble Wrap for Storing Liquid Samples and Performing Analytical Assays 

      Bwambok, David K.; Christodouleas, Dionysios; Morin, Stephen A.; Lange, Heiko; Phillips, Scott T.; Whitesides, George McClelland (American Chemical Society (ACS), 2014)
      This paper demonstrates that the gas-filled compartments in the packing material commonly called “bubble wrap” can be repurposed in resource-limited regions as containers to store liquid samples, and to perform bioanalyses. ...
    • Analog Modeling of Worm-Like Chain Molecules Using Macroscopic Beads-on-a-String 

      Tricard, Simon; Feinstein, Efraim; Shepherd, Robert F.; Reches, Meital; Snyder, Phillip W.; Bandarage, Dileni C.; Prentiss, Mara; Whitesides, George M. (Royal Society of Chemistry (RSC), 2012)
      This paper describes an empirical model of polymer dynamics, based on the agitation of millimeter-sized polymeric beads. Although the interactions between the particles in the macroscopic model, and those between the ...
    • Analysis of Inorganic Polyphosphates by Capillary Gel Electrophoresis 

      Lee, Andrew; Whitesides, George M. (American Chemical Society, 2010)
      This paper describes the development of a method that uses capillary gel electrophoresis (CGE) to analyze mixtures of inorganic polyphosphate ((P\(_i\))\(_n\)). Resolution of (P\(_i\))\(_n\) on the basis of n, the number ...
    • Analytical Devices Based on Direct Synthesis of DNA on Paper 

      Glavan, Ana C; Niu, Jia; Chen, Zhen; Güder, Firat; Cheng, Chao-Min; Liu, David Ruchien; Whitesides, George McClelland (American Chemical Society (ACS), 2016)
      This paper addresses a growing need in clinical diagnostics for parallel, multiplex analysis of biomarkers from small biological samples. It describes a new procedure for assembling microarrays of ssDNA and proteins on ...
    • Analyzing Forensic Evidence Based on Density with Magnetic Levitation 

      Lockett, Matthew; Mirica, Katherine A.; Mace, Charles R.; Blackledge, Robert D.; Whitesides, George M. (Wiley-Blackwell, 2013)
      This paper describes a method for determining the density of contact trace objects with magnetic levitation (MagLev). MagLev measurements accurately determine the density (±0.0002 g/cm3) of a diamagnetic object and are ...
    • Anomalously Rapid Tunneling: Charge Transport across Self-Assembled Monolayers of Oligo(ethylene glycol) 

      Baghbanzadeh, Mostafa; Bowers, Carleen M.; Rappoport, Dmitrij; ?aba, Tomasz; Yuan, Li; Kang, Kyungtae; Liao, Kung-Ching; Gonidec, Mathieu; Rothemund, Philipp Josef Michael; Cyganik, Piotr; Aspuru-Guzik, Alan; Whitesides, George McClelland (American Chemical Society (ACS), 2017)
      This paper describes charge transport by tunneling across self-assembled monolayers (SAMs) of thiol-terminated derivatives of oligo(ethylene glycol) (HS(CH2CH2O)nCH3; HS(EG)nCH3); these SAMs are positioned between gold ...
    • Aqueous Multiphase Systems of Polymers and Surfactants Provide Self-Assembling Step-Gradients in Density 

      Mace, Charles R.; Akbulut, Ozge; Kumar, Ashok Ashwin; Shapiro, Nathan D.; Derda, Ratmir; Patton, Matthew Reiser; Whitesides, George McClelland (American Chemical Society, 2012)
      This Communication demonstrates the generation of over 300 phase-separated systems—ranging from two to six phases—from mixtures of aqueous solutions of polymers and surfactants. These aqueous multiphase systems (MuPSs) ...
    • Arthrobots 

      Nemiroski, Alex; Shevchenko, Yanina Y.; Stokes, Adam A.; Unal, Baris; Ainla, Alar; Albert, Sahradha; Compton, Gabrielle; MacDonald, Emily; Schwab, Yosyp; Zellhofer, Caroline; Whitesides, George McClelland (Mary Ann Liebert Inc, 2017)
      This paper describes a class of robots—“arthrobots”— inspired, in part, by the musculoskeletal system of arthropods (spiders and insects, inter alia). An exoskeleton, constructed from thin organic polymeric tubes, provides ...
    • Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions 

      Semenov, Sergey N.; Kraft, Lewis J.; Ainla, Alar; Zhao, Mengxia; Baghbanzadeh, Mostafa; Campbell, Victoria; Kang, Kyungtae; Fox, Jerome; Whitesides, George McClelland (Springer Nature, 2016)
      Networks of organic chemical reactions are centrally important in life, and were likely to have played a central role in its origins. Network dynamics regulate cell division, circadian rhythms, nerve impulses, chemotaxis, ...
    • The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand 

      Lockett, Matthew R.; Lange, Heiko; Breiten, Benjamin; Heroux, Annie; Sherman, Woody; Rappoport, Dmitrij; Yau, Patricia O.; Snyder, Philip W.; Whitesides, George McClelland (Wiley-VCH Verlag Berlin, 2013)
      Auf das Wasser kommt es an: Konservierte Bindungsgeometrie, enthalpiegetriebene Bindungsweise und nichtunterscheidbare Bindungsaffinitäten für fluorierte und nichtfluorierte Liganden von humaner Carbonsäureanhydrase (siehe ...
    • Bioinspiration: something for everyone 

      Whitesides, George M. (The Royal Society, 2015)
      ‘Bioinspiration’—using phenomena in biology to stimulate research in non-biological science and technology—is a strategy that suggests new areas for research. Beyond its potential to nucleate new ideas, bioinspiration has ...
    • Biomineralization Guided by Paper Templates 

      Camci-Unal, Gulden; Laromaine, Anna; Hong, Estrella; Derda, Ratmir; Whitesides, George M. (Nature Publishing Group, 2016)
      This work demonstrates the fabrication of partially mineralized scaffolds fabricated in 3D shapes using paper by folding, and by supporting deposition of calcium phosphate by osteoblasts cultured in these scaffolds. This ...
    • Broadly Available Imaging Devices Enable High-Quality Low-Cost Photometry 

      Christodouleas, Dionysios; Nemiroski, Alex; Kumar, Ashok Ashwin; Whitesides, George McClelland (American Chemical Society (ACS), 2015)
      This paper demonstrates that, for applications in resource-limited environments, expensive microplate spectrophotometers that are used in many central laboratories for parallel measurement of absorbance of samples can be ...
    • Bubbles navigating through networks of microchannels 

      Choi, Wonjae; Hashimoto, Michinao; Ellerbee, Audrey K.; Chen, Xin; Bishop, Kyle J. M.; Garstecki, Piotr; Stone, Howard A.; Whitesides, George McClelland (Royal Society of Chemistry (RSC), 2011)
      This paper describes the behavior of bubbles suspended in a carrier liquid and moving within microfluidic networks of different connectivities. A single-phase continuum fluid, when flowing in a network of channels, partitions ...
    • Buckling of Elastomeric Beams Enables Actuation of Soft Machines 

      Yang, Dian; Mosadegh, Bobak; Ainla, Alar; Lee, Ben Charles Germain; Khashai, Fatemeh; Suo, Zhigang; Bertoldi, Katia; Whitesides, George McClelland (Wiley-Blackwell, 2015)
      Soft, pneumatic actuators that buckle when interior pressure is less than exterior provide a new mechanism of actuation. Upon application of negative pneumatic pressure, elastic beam elements in these actuators undergo ...
    • Buckling Pneumatic Linear Actuators Inspired by Muscle 

      Yang, Dian; Verma, Mohit Singh; So, Ju-Hee; Mosadegh, Bobak; Keplinger, Christoph; Lee, Benjamin; Khashai, Fatemeh; Lossner, Elton Garret; Suo, Zhigang; Whitesides, George McClelland (Wiley-Blackwell, 2016)
      The mechanical features of biological muscles are difficult to reproduce completely in synthetic systems. A new class of soft pneumatic structures (vacuum-actuated muscle-inspired pneumatic structures) is described that ...
    • Camouflage and Display for Soft Machines 

      Morin, Stephen A.; Shepherd, Robert F.; Kwok, Sen Wai; Stokes, Adam A.; Nemiroski, Alex; Whitesides, George M. (American Association for the Advancement of Science (AAAS), 2012)
      Synthetic systems cannot easily mimic the color-changing abilities of animals such as cephalopods. Soft machines—machines fabricated from soft polymers and flexible reinforcing sheets—are rapidly increasing in functionality. ...