Now showing items 1-9 of 9

    • AC and AG Dinucleotide Repeats in the PAX6 P1 Promoter are Associated with High Myopia 

      Ng, Tsz Kin; Lam, Ching Yan; Lam, Dennis Shun Chiu; Chiang, Sylvia Wai Yee; Tam, Pancy Oi Sin; Yam, Gary Hin-Fai; Fan, Dorothy Shu Ping; Pang, Chi Pui; Wang, Danyi; Fan, Baojian (Molecular Vision, 2009)
      Purpose: The PAX6 gene, located at the reported myopia locus MYP7 on chromosome 11p13, was postulated to be associated with myopia development. This study investigated the association of PAX6 with high myopia in 379 high ...
    • Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma 

      Yaspan, Brian L.; Hauser, Michael A.; Allingham, R. Rand; Olson, Lana M.; Abdrabou, Wael; Brodeur, Wendy; Budenz, Donald L.; Caprioli, Joseph; Crenshaw, Andrew; Crooks, Kristy; DelBono, Elizabeth; Doheny, Kimberly F.; Gaasterland, Douglas; Gaasterland, Terry; Laurie, Cathy; Lichter, Paul R.; Loomis, Stephanie; Liu, Yutao; Medeiros, Felipe A.; McCarty, Cathy; Mirel, Daniel; Moroi, Sayoko E.; Musch, David C.; Realini, Anthony; Rozsa, Frank W.; Schuman, Joel S.; Scott, Kathleen; Singh, Kuldev; Trager, Edward H.; VanVeldhuisen, Paul; Vollrath, Douglas; Wollstein, Gadi; Yoneyama, Sachiko; Zhang, Kang; Weinreb, Robert N.; Ernst, Jason; Masuda, Tomohiro; Zack, Don; Richards, Julia E.; Pericak-Vance, Margaret; Haines, Jonathan L.; Wiggs, Janey Lee; Kang, Jae Hee Hee; Fan, Baojian; Wang, Danyi; Friedman, David S.; Lee, Richard K.; Stein, Joshua D.; Kellis, Manolis; Pasquale, Louis (Public Library of Science, 2012)
      Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve ...
    • Different WDR36 Mutation Pattern in Chinese Patients with Primary Open-angle Glaucoma 

      Fan, Baojian; Wang, Danyi; Cheng, Ching-Yu; Ko, Wendy Charles; Lam, Shun Chiu; Pang, Chi Pui (Molecular Vision, 2009)
      Purpose: To determine the distribution of WD repeat domain 36 (WDR36) sequence variants in Chinese patients with primary open-angle glaucoma (POAG). Methods: One hundred and thirty-five unrelated POAG patients (82 high ...
    • Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness 

      Desronvil, T.; Logan-Wyatt, D.; Abdrabou, W.; Triana, M.; Taheri, S.; Del Bono, E.; Olivier, M.; Jones, Richard Norman; Pasquale, Louis; Haines, J. L.; Fan, Baojian; Wiggs, Janey Lee (Molecular Vision, 2010)
      Purpose: One approach to identify genes that contribute to common complex ocular disorders such as primary open angle glaucoma (POAG) is to study the genetic determinates of endophenotypes that are defined by underlying ...
    • DNA Sequence Variants in the LOXL1 Gene are Associated with Pseudoexfoliation Glaucoma in a U.S. Clinic-Based Population with Broad Ethnic Diversity 

      del Bono, Elizabeth; Haines, Jonathan L; Fan, Baojian; Pasquale, Louis; Grosskreutz, Cynthia Lee; Rhee, Douglas J.; Chen, Teresa Chia-Ching; DeAngelis, Margaret M.; Kim, Ivana Kyung; Miller, Joan Whitten; Li, Tiansen; Wiggs, Janey Lee (BioMed Central, 2008)
      Background: Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs ...
    • EDN1 Lys198Asn is Associated with Diabetic Retinopathy in Type 2 Diabetes 

      Li, Haitao; Louey, Janice W.C.; Choy, Kwong Wai; Chan, Yiu Man; Fung, Nicholas S.K.; Baum, Larry; Chan, Juliana C.N.; Lam, Dennis S.C.; Pang, Chi Pui; Liu, David T. L.; Chan, Wai Man; Fan, Baojian (Molecular Vision, 2008)
      Purpose: We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR). Methods: A case-control study was ...
    • Lack of Association of Polymorphisms in Homocysteine Metabolism Genes with Pseudoexfoliation Syndrome and Glaucoma 

      Fan, Baojian; Chen, Teresa Chia-Ching; Grosskreutz, Cynthia Lee; Pasquale, Louis; Rhee, Douglas J; DelBono, Elizabeth; Haines, Jonathan L.; Wiggs, Janey Lee (Molecular Vision, 2008)
      Purpose: To evaluate genes involved in homocysteine metabolism as secondary risk factors for pseudoexfoliation syndrome (PXFS) and the associated glaucoma (PXFG). Methods: One hundred eighty-six unrelated patients with ...
    • The p53 Codon 72 PRO/PRO Genotype May Be Associated with Initial Central Visual Field Defects in Caucasians with Primary Open Angle Glaucoma 

      Wiggs, Janey Lee; Hewitt, Alex W.; Fan, Baojian; Wang, Danyi; Figueiredo Sena, Dayse R.; O’Brien, Colm; Realini, Anthony; Craig, Jamie E.; Dimasi, David P.; Mackey, David A.; Haines, Jonathan L.; Pasquale, Louis (Public Library of Science, 2012)
      Background: Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. In this study we ...
    • SNP rs1533428 at 2p16.3 as a marker for late-onset primary open-angle glaucoma 

      Tam, Pancy O.S.; Leung, Dexter Y.L.; Fan, Alex H.; Zhang, Mingzhi; Tham, Clement C.Y.; Wang, Ningli; Pang, Chi Pui; Chen, Li Jia; Fan, Baojian; Chiang, Sylvia W.Y. (Molecular Vision, 2012)
      Purpose: To investigate the associations between gene variants in cholesterol 24S-hydroxylase (CYP46A1), LIM homeobox transcription factor 1-beta (LMX1B), plexin domain containing 2 (PLXDC2), toll-like receptor 4 (TLR4), ...