Now showing items 1-12 of 12

    • Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis 

      Tanabe, Kenneth Kenji; Lemoine, Antoinette; Finkelstein, Dianne Madelyn; Kawasaki, Hiroshi; Fujii, Tsutomu; Chung, Raymond Taeyong; Lauwers, Gregory Y.; Kulu, Yakup; Muzikansky, Alona; Kuruppu, Darshini; Lanuti, Michael; Goodwin, Jonathan M.; Azoulay, Daniel; Fuchs, Bryan C. (American Medical Association (AMA), 2008)
      Context: Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. Objective: To assess the ...
    • Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver 

      Naba, Alexandra; Clauser, Karl R; Whittaker, Charles A; Carr, Steven A; Tanabe, Kenneth K; Hynes, Richard O (BioMed Central, 2014)
      Background: Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis ...
    • A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients 

      Suenaga, Masaya; Yamada, Suguru; Fujii, Tsutomu; Fuchs, Bryan C; Okumura, Norio; Kanda, Mitsuro; Kobayashi, Daisuke; Tanaka, Chie; Nakayama, Goro; Sugimoto, Hiroyuki; Koike, Masahiko; Nomoto, Shuji; Fujiwara, Michitaka; Takeda, Shin; Hayashi, Kazuhiko; Tanabe, Kenneth K; Goto, Hidemi; Kodera, Yasuhiro (Dove Medical Press, 2013)
      Background: A single nucleotide polymorphism (SNP) in the epidermal growth factor (EGF) gene (rs4444903) has been associated with increased risk of cancer, including hepatocellular carcinoma (HCC). The aim of this study ...
    • Gallbladder Lesions Identified on Ultrasound. Lessons from the Last 10 Years 

      Konstantinidis, Ioannis T; Bajpai, Surabhi; Kambadakone, Avinash R.; Tanabe, Kenneth Kenji; Berger, David Lawrence; Hui, Hui; Sahani, Dushyant V.; Lauwers, Gregory Y.; Fernandez-Del Castillo, Carlos F.; Warshaw, Andrew Louis; Ferrone, Cristina Rosa (Springer Nature, 2011)
      Background: Possible mass lesions identified on ultrasound (US) of the gallbladder may prompt an aggressive surgical intervention due to the possibility of a malignant neoplasm. Aim: This study aims to utilize a large ...
    • Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis 

      King, Lindsay Y.; Johnson, Kara B.; Zheng, Hui; Wei, Lan; Gudewicz, Thomas; Hoshida, Yujin; Corey, Kathleen E.; Ajayi, Tokunbo; Ufere, Nneka; Baumert, Thomas F.; Chan, Andrew T.; Tanabe, Kenneth K.; Fuchs, Bryan C.; Chung, Raymond T. (Public Library of Science, 2014)
      Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene ...
    • Long-term Risk of False-Positive Screening Results and Subsequent Biopsy as a Function of Mammography Use 

      Blanchard, Karen; Colbert, James Adam; Kopans, Daniel Benjamin; Moore, Richard; Halpern, Elkan F.; Hughes, Kevin S.; Smith, Barbara L; Tanabe, Kenneth Kenji; Michaelson, James Selib (Radiological Society of North America (RSNA), 2006)
    • Molecular MR Imaging of Liver Fibrosis: A Feasibility Study Using Rat and Mouse Models 

      Polasek, Miloslav; Fuchs, Bryan C.; Uppal, Ritika; Schühle, Daniel T.; Alford, Jamu K.; Loving, Galen S.; Yamada, Suguru; Wei, Lan; Lauwers, Gregory Y.; Guimaraes, Alexander Savio Ramos; Tanabe, Kenneth Kenji; Caravan, Peter D. (Elsevier BV, 2012)
      Background & Aims: Liver biopsy, the current clinical gold standard for fibrosis assessment, is invasive and has sampling errors, and is not optimal for screening, monitoring, or clinical decision-making. Fibrosis is ...
    • Molecular MRI of Collagen to Diagnose and Stage Liver Fibrosis 

      Fuchs, Bryan C.; Wang, Huifang; Yang, Yanfei; Wei, Lan; Polasek, Miloslav; Schühle, Daniel T.; Lauwers, Gregory Y.; Parkar, Ashfaq; Sinskey, Anthony J.; Tanabe, Kenneth Kenji; Caravan, Peter D. (Elsevier BV, 2013)
      Background & Aims The gold standard in assessing liver fibrosis is biopsy despite limitations like invasiveness and sampling error and complications including morbidity and mortality. Therefore, there is a major unmet ...
    • Mouse Model of Carbon Tetrachloride Induced Liver Fibrosis: Histopathological Changes and Expression of CD133 and Epidermal Growth Factor 

      Fujii, Tsutomu; Fuchs, Bryan C.; Yamada, Suguru; Lauwers, Gregory Y.; Kulu, Yakup; Goodwin, Jonathan M; Lanuti, Michael; Tanabe, Kenneth Kenji (BioMed Central, 2010)
      Background: In the setting of chronic liver injury in humans, epidermal growth factor (EGF) and EGF receptor (EGFR) are up-regulated and have been proposed to have vital roles in both liver regeneration and development of ...
    • A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors 

      Hong, Theodore Sunki; Delaney, Thomas F.; Mamon, Harvey Jay; Willett, Christopher G.; Yeap, Beow Yong; Niemierko, Andrzej; Wolfgang, John A.; Lu, Hsiao-ming; Adams, Judith; Weyman, Elizabeth A.; Arellano, Ronald Steven; Blaszkowsky, Lawrence Scott; Allen, Jill; Tanabe, Kenneth Kenji; Ryan, David P.; Zhu, Andrew Xiuxuan (Elsevier BV, 2014)
      Purpose To evaluate the feasibility of a respiratory-gated proton beam therapy for liver tumors. Materials and Methods Fifteen patients were enrolled on a prospective IRB-approved protocol. Eligibility criteria ...
    • Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis 

      Rubbia-Brandt, Laura; Lauwers, Gregory Y.; Wang, Huamin; Majno, Pietro E; Tanabe, Kenneth Kenji; X Zhu, Andrew; Brezault, Catherine; Soubrane, Olivier; Abdalla, Eddie K; Vauthey, Jean-Nicolas; Mentha, Gilles; Terris, Benoit (Wiley-Blackwell, 2010)
      AIMS: Because of its efficacy, oxaliplatin (OX) is increasingly used as a chemotherapeutic agent in the treatment of colorectal liver metastases (CRLM). Oxaliplatin-associated liver toxicity has been reported and can affect ...
    • Trends in Presentation and Survival for Gallbladder Cancer During a Period of More Than 4 Decades 

      Konstantinidis, Ioannis T; Deshpande, Vikram; Genevay, Muriel; Berger, David Lawrence; Fernandez-Del Castillo, Carlos F.; Tanabe, Kenneth Kenji; Hui, Hui; Lauwers, Gregory Y.; Ferrone, Cristina Rosa (American Medical Association (AMA), 2009)
      Objectives: To determine the prevalence of incidentally found cases of gallbladder cancer, the incidence of residual disease at reexploration, and the changes in the mode of presentation, treatment, and survival of patients ...