Now showing items 1-5 of 5

    • Cooperation and the Fate of Microbial Societies 

      Allen, Benjamin Isaac; Nowak, Martin A. (Public Library of Science, 2013)
      Microorganisms have been cooperating with each other for billions of years: by sharing resources, communicating with each other, and joining together to form biofilms and other large structures. These cooperative behaviors ...
    • The effect of one additional driver mutation on tumor progression 

      Reiter, Johannes G; Bozic, Ivana; Allen, Benjamin Isaac; Chatterjee, Krishnendu; Nowak, Martin A. (Blackwell Publishing Ltd, 2013)
      Tumor growth is caused by the acquisition of driver mutations, which enhance the net reproductive rate of cells. Driver mutations may increase cell division, reduce cell death, or allow cells to overcome density-limiting ...
    • Evolutionary dynamics of cancer in response to targeted combination therapy 

      Bozic, Ivana; Reiter, Johannes G; Allen, Benjamin; Antal, Tibor; Chatterjee, Krishnendu; Shah, Preya; Moon, Yo Sup; Yaqubie, Amin; Kelly, Nicole; Le, Dung T; Lipson, Evan J; Chapman, Paul B; Diaz, Luis A; Vogelstein, Bert; Nowak, Martin A (eLife Sciences Publications, Ltd, 2013)
      In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major strategy proposed for overcoming resistance is combination therapy. ...
    • Inclusive Fitness Theorizing Invokes Phenomena That Are Not Relevant for the Evolution of Eusociality 

      Nowak, Martin A.; Allen, Benjamin (Public Library of Science, 2015)
      In this Formal Comment, the authors challenge the claims of a recent theoretical study that genetic relatedness is important in the evolution of eusociality.
    • A population-based experimental model for protein evolution: Effects of mutation rate and selection stringency on evolutionary outcomes 

      Leconte, Aaron M.; Dickinson, Bryan; Yang, David D.; Chen, Irene; Allen, Benjamin; Liu, David Ruchien (American Chemical Society (ACS), 2013)
      Protein evolution is a critical component of organismal evolution and a valuable method for the generation of useful molecules in the laboratory. Few studies, however, have experimentally characterized how fundamental ...