Browsing by Author "Guo, Guoji"

Now showing items 1-4 of 4

    • Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis 

      Saadatpour, Assieh; Guo, Guoji; Orkin, Stuart H; Yuan, Guo-Cheng (BioMed Central, 2014)
      Background: A fundamental challenge for cancer therapy is that each tumor contains a highly heterogeneous cell population whose structure and mechanistic underpinnings remain incompletely understood. Recent advances in ...

    • Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation 

      Kerenyi, Marc A; Shao, Zhen; Hsu, Yu-Jung; Guo, Guoji; Luc, Sidinh; O'Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H (eLife Sciences Publications, Ltd, 2013)
      Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic ...

    • Live-Animal Imaging of Native Hematopoietic Stem and Progenitor Cells 

      Christodoulou, Constantina; Spencer, Joel; Yeh, Shu-Chi; Turcotte, Raphaele; Kokkaliaris, Konstantinos; Panero, Riccardo; Ramos, Azucena; Guo, Guoji; Seyedhassantehrani, N; Esipova, TV; Vinogradov, SA; Rudzinskas, S; Zhang, Y; Perkins, Archibald; Orkin, Stuart; Calogero, Rafaele; Schroeder, Tim; Lin, Charles; Camargo, Fernando (SpringerNature, 2020-02-05)
      The biology of hematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions. Particularly challenging has been the study of dynamic HSC behaviors in the native niche given that live animal ...

    • Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer 

      Kim, Woojin; Bird, Gregory H.; Neff, Tobias; Guo, Guoji; Kerenyi, Marc A.; Walensky, Loren D.; Orkin, Stuart H. (2013)
      Enhancer of zeste homolog2 (EZH2) is the histone lysine N-methyltransferase component of the Polycomb repressive complex 2 (PRC2), which in conjunction with embryonic ectoderm development (EED) and suppressor of zeste 12 ...