Browsing by Author "Guo, Guoji"

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Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis

Saadatpour, Assieh; Guo, Guoji; Orkin, Stuart H; Yuan, Guo-Cheng (BioMed Central, 2014)

Background: A fundamental challenge for cancer therapy is that each tumor contains a highly heterogeneous cell population whose structure and mechanistic underpinnings remain incompletely understood. Recent advances in ...
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

Kerenyi, Marc A; Shao, Zhen; Hsu, Yu-Jung; Guo, Guoji; Luc, Sidinh; O'Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H (eLife Sciences Publications, Ltd, 2013)

Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic ...
Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer

Kim, Woojin; Bird, Gregory H.; Neff, Tobias; Guo, Guoji; Kerenyi, Marc A.; Walensky, Loren D.; Orkin, Stuart H. (2013)

Enhancer of zeste homolog2 (EZH2) is the histone lysine N-methyltransferase component of the Polycomb repressive complex 2 (PRC2), which in conjunction with embryonic ectoderm development (EED) and suppressor of zeste 12 ...