Browsing by Author "Guo, Guoji"
Now showing items 1-3 of 3
-
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis
Saadatpour, Assieh; Guo, Guoji; Orkin, Stuart H; Yuan, Guo-Cheng (BioMed Central, 2014)Background: A fundamental challenge for cancer therapy is that each tumor contains a highly heterogeneous cell population whose structure and mechanistic underpinnings remain incompletely understood. Recent advances in ... -
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
Kerenyi, Marc A; Shao, Zhen; Hsu, Yu-Jung; Guo, Guoji; Luc, Sidinh; O'Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H (eLife Sciences Publications, Ltd, 2013)Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic ... -
Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer
Kim, Woojin; Bird, Gregory H.; Neff, Tobias; Guo, Guoji; Kerenyi, Marc A.; Walensky, Loren D.; Orkin, Stuart H. (2013)Enhancer of zeste homolog2 (EZH2) is the histone lysine N-methyltransferase component of the Polycomb repressive complex 2 (PRC2), which in conjunction with embryonic ectoderm development (EED) and suppressor of zeste 12 ...