Now showing items 1-5 of 5

    • Effect of Phosphodiesterase Inhibition on Insulin Resistance in Obese Individuals 

      Ho, Jennifer E.; Arora, Pankaj; Walford, Geoffrey A.; Ghorbani, Anahita; Guanaga, Derek P.; Dhakal, Bishnu P.; Nathan, Daniel I.; Buys, Emmanuel S.; Florez, Jose C.; Newton‐Cheh, Christopher; Lewis, Gregory D.; Wang, Thomas J. (Blackwell Publishing Ltd, 2014)
      Background: Obesity is associated with cardiometabolic disease, including insulin resistance (IR) and diabetes. Cyclic guanosine monophosphate (cGMP) signaling affects energy balance, IR, and glucose metabolism in experimental ...
    • The emerging role of metabolomics in the development of biomarkers for pulmonary hypertension and other cardiovascular diseases (2013 Grover Conference series) 

      Lewis, Gregory D. (University of Chicago Press, 2014)
      Abstract The functional and prognostic significance of pulmonary hypertension (PH) is well established, yet our understanding of circulating peptides and metabolites that might mark or contribute to various forms of PH ...
    • Interpreting Metabolomic Profiles using Unbiased Pathway Models 

      Hunter, Luke; Pare, Guillaume; Vasan, Ramachandran S.; Lewis, Gregory D; Wang, Thomas Jue-Fuu; Chasman, Daniel Ian; Gerszten, Robert Edgardo; Deo, Rahul Chandrakant; Roth, Frederick Phillip (Public Library of Science, 2010)
      Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...
    • Submaximal Exercise Systolic Blood Pressure and Heart Rate at 20 Years of Follow‐up: Correlates in the Framingham Heart Study 

      Spartano, Nicole L.; Lyass, Asya; Larson, Martin G.; Lewis, Gregory D.; Vasan, Ramachandran S. (John Wiley and Sons Inc., 2016)
      Background: Beyond their resting values, exercise responses in blood pressure (BP) and heart rate (HR) may add prognostic information for cardiovascular disease (CVD). In cross‐sectional studies, exercise BP and HR responses ...
    • β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors 

      Roberts, Lee D.; Boström, Pontus; O’Sullivan, John F.; Schinzel, Robert T.; Lewis, Gregory D; Dejam, Andre; Lee, Youn-Kyoung; Palma, Melinda J.; Calhoun, Sondra; Georgiadi, Anastasia; Chen, Ming-Huei; Ramachandran, Vasan S.; Larson, Martin G.; Bouchard, Claude; Rankinen, Tuomo; Souza, Amanda L.; Clish, Clary B.; Wang, Thomas J.; Estall, Jennifer L.; Soukas, Alexander Anastasios; Cowan, Chad A.; Spiegelman, Bruce Michael; Gerszten, Robert Edgardo (Elsevier BV, 2014)
      The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise. Muscle PGC-1α ...