Now showing items 1-4 of 4

    • An Antibody-Based Leukocyte-Capture Microarray for the Diagnosis of Systemic Lupus Erythematosus 

      Lin, Ming-Wei; Ho, Joshua Wing Kei; Harrison, Leonard C.; dos Remedios, Cristobal G.; Adelstein, Stephen (Public Library of Science, 2013)
      The diagnosis of Systemic Lupus Erythematosus (SLE) is challenging due to its heterogeneous clinical presentation and the lack of robust biomarkers to distinguish it from other autoimmune diseases. Further, currently used ...
    • ChIP-chip versus ChIP-seq: Lessons for Experimental Design and Data Analysis 

      Ho, Joshua Wing Kei; Bishop, Eric; Karchenko, Peter V; Nègre, Nicolas; White, Kevin P; Park, Peter J. (BioMed Central, 2011)
      Background: Chromatin immunoprecipitation (ChIP) followed by microarray hybridization (ChIP-chip) or high-throughput sequencing (ChIP-seq) allows genome-wide discovery of protein-DNA interactions such as transcription ...
    • An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud 

      Lachke, Salil A.; O’Connell, Daniel J.; Aboukhalil, Anton; Choe, Sung E.; Turbe-Doan, Annick; Robertson, Erin A.; Amendt, Brad A.; Jumlongras, Dolrudee; Li, Xiao; Ho, Joshua Wing Kei; Olsen, Bjorn Reino; Bulyk, Martha Leonia; Maas, Richard Louis (Public Library of Science, 2012)
      To elucidate the transcriptional regulation of Bmp4 expression during organogenesis, we used phylogenetic footprinting and transgenic reporter analyses to identify Bmp4 cis-regulatory modules (CRMs). These analyses identified ...
    • Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context 

      Alekseyenko, Artyom A.; Gelbart, Marnie; Tolstorukov, Michael Y.; Gorchakov, Andrey A.; Larschan, Erica; Gu, Tingting; Minoda, Aki; Riddle, Nicole C.; Schwartz, Yuri B.; Elgin, Sarah C. R.; Karpen, Gary H.; Pirrotta, Vincenzo; Ho, Joshua Wing Kei; Peng, Shouyong; Plachetka, Annette; Kharchenko, Peter Vasili; Jung, Youngsook; Kuroda, Mitzi I.; Park, Peter J. (Public Library of Science, 2012)
      The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X chromosome and subsequent ...