Now showing items 1-20 of 20

    • Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes 

      Veiga, Patrick; Gallini, Carey Ann; Beal, C.; Michaud, Monia; Delaney, Mary Louise Rodriguez; DuBois, A.; Khlebnikov, A.; van Hylckama Vlieg, J. E. T.; Punit, S.; Glickman, Jonathan Neil; Onderdonk, Andrew Bruce; Glimcher, Laurie Hollis; Garrett, Wendy S. (Proceedings of the National Academy of Sciences, 2010)
      Intestinal health requires the coexistence of eukaryotic self with the gut microbiota and dysregulated host-microbial interactions can result in intestinal inflammation. Here, we show that colitis improved in T-bet(-/-)Rag2(-/-) ...
    • CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function 

      Chun, Eunyoung; Lavoie, Sydney; Michaud, Monia; Gallini, Carey Ann; Kim, Jason; Soucy, Genevieve; Odze, Robert; Glickman, Jonathan N.; Garrett, Wendy S. (2015)
      Summary Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that ...
    • Computational meta'omics for microbial community studies 

      Segata, Nicola; Boernigen, Daniela; Tickle, Timothy L; Morgan, Xochitl C; Garrett, Wendy S; Huttenhower, Curtis (European Molecular Biology Organization, 2013)
      Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture-independent approaches have provided new insights into their structure ...
    • Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes 

      Zhang, Chenhong; Derrien, Muriel; Levenez, Florence; Brazeilles, Rémi; Ballal, Sonia A; Kim, Jason; Degivry, Marie-Christine; Quéré, Gaëlle; Garault, Peggy; van Hylckama Vlieg, Johan E T; Garrett, Wendy S; Doré, Joël; Veiga, Patrick (Nature Publishing Group, 2016)
      Resident gut microbes co-exist with transient bacteria to form the gut microbiota. Despite increasing evidence suggesting a role for transient microbes on gut microbiota function, the interplay between resident and transient ...
    • Exploring host-microbiota interactions in animal models and humans 

      Kostic, Aleksandar David; Howitt, Michael; Garrett, Wendy S. (Cold Spring Harbor Laboratory Press, 2013)
      The animal and bacterial kingdoms have coevolved and coadapted in response to environmental selective pressures over hundreds of millions of years. The meta'omics revolution in both sequencing and its analytic pipelines ...
    • From cell biology to the microbiome: An intentional infinite loop 

      Garrett, Wendy S. (The Rockefeller University Press, 2015)
      Cell biology is the study of the structure and function of the unit or units of living organisms. Enabled by current and evolving technologies, cell biologists today are embracing new scientific challenges that span many ...
    • Functional profiling of the gut microbiome in disease-associated inflammation 

      Börnigen, Daniela; Morgan, Xochitl C; Franzosa, Eric A; Ren, Boyu; Xavier, Ramnik J; Garrett, Wendy S; Huttenhower, Curtis (BioMed Central, 2013)
      The microbial residents of the human gut are a major factor in the development and lifelong maintenance of health. The gut microbiota differs to a large degree from person to person and has an important influence on health ...
    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma 

      Kostic, Aleksandar David; Gevers, D.; Pedamallu, Chandra Sekhar; Michaud, Monia; Duke, F.; Earl, A. M.; Ojesina, Akinyemi Ifedapo; Jung, J.; Bass, Adam Joel; Tabernero, J.; Baselga, J.; Liu, C.; Shivdasani, Ramesh Arjun; Ogino, Shuji; Birren, B. W.; Huttenhower, Curtis; Garrett, Wendy S.; Meyerson, Matthew Langer (Cold Spring Harbor Laboratory Press, 2011)
      The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to ...
    • Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission 

      Rooks, Michelle G; Veiga, Patrick; Wardwell-Scott, Leslie H; Tickle, Timothy; Segata, Nicola; Michaud, Monia; Gallini, Carey Ann; Beal, Chloé; van Hylckama-Vlieg, Johan ET; Ballal, Sonia Arora; Morgan, Xochitl C; Glickman, Jonathan Neil; Gevers, Dirk; Huttenhower, Curtis; Garrett, Wendy S. (Springer Nature, 2014)
      Dysregulated immune responses to gut microbes are central to inflammatory bowel disease (IBD), and gut microbial activity can fuel chronic inflammation. Examining how IBD-directed therapies influence gut microbiomes may ...
    • The Gut Microbiota and Mucosal T Cells 

      Smith, Patrick M.; Garrett, Wendy S. (Frontiers Media SA, 2011)
      It is intuitive that immune cells in the gut may require microbiota-derived cues for their differentiation. The proximity between host and microbe in the intestine would seemingly necessitate co-adaptation. However, it has ...
    • Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013 

      Ravel, Jacques; Blaser, Martin J; Braun, Jonathan; Brown, Eric; Bushman, Frederic D; Chang, Eugene B; Davies, Julian; Dewey, Kathryn G; Dinan, Timothy; Dominguez-Bello, Maria; Erdman, Susan E; Finlay, B Brett; Garrett, Wendy S; Huffnagle, Gary B; Huttenhower, Curtis; Jansson, Janet; Jeffery, Ian B; Jobin, Christian; Khoruts, Alexander; Kong, Heidi H; Lampe, Johanna W; Ley, Ruth E; Littman, Dan R; Mazmanian, Sarkis K; Mills, David A; Neish, Andrew S; Petrof, Elaine; Relman, David A; Rhodes, Rosamond; Turnbaugh, Peter J; Young, Vincent B; Knight, Rob; White, Owen (BioMed Central, 2014)
      A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at ...
    • Mechanisms of regulatory T cell lineage homeostasis and stability 

      Huynh, Alexandria (2015-05-12)
      Defined by the transcription factor Foxp3, regulatory T cells (Tregs) are a lineage of CD4+ T lymphocytes critical for the maintenance of immune homeostasis and tolerance. A lack of functional Tregs in both mice and humans ...
    • Metagenomic biomarker discovery and explanation 

      Segata, Nicola; Izard, Jacques; Waldron, Levi; Gevers, Dirk; Miropolsky, Larisa; Garrett, Wendy S.; Huttenhower, Curtis (Springer Science + Business Media, 2011)
      This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, ...
    • Microbial Community Function and Biomarker Discovery in the Human Microbiome 

      Abubucker, Sahar; Goll, Johannes; Schubert, Alyxandria M; Cantarel, Brandi L; Rodriguez-Mueller, Beltran; Thiagarajan, Mathangi; Henrissat, Bernard; White, Owen; Kelley, Scott T; Methé, Barbara; Schloss, Patrick D; Gevers, Dirk; Mitreva, Makedonka; Izard, Jacques Georges; Waldron, Levi D.; Zucker, Jeremy Daniel Hofeld; Garrett, Wendy S.; Huttenhower, Curtis; Segata, Nicola (BioMed Central, 2011)
    • The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis 

      Smith, Patrick M.; Howitt, Michael; Panikov, Nicolai; Michaud, Monia; Gallini, Carey Ann; Bohlooly-Y, Mohammad; Glickman, Jonathan Neil; Garrett, Wendy S. (American Association for the Advancement of Science (AAAS), 2013)
      Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial species and strain-specific molecules that ...
    • Microbiome-Targeted Interventions for Colitis-Associated Bacteria 

      Rooks, Michelle Gabrielle (2016-05-06)
      Complex interactions between mammalian hosts and their gut microbes have evolved over many millennia and have established a sophisticated communication system that is essential for symbiosis and mutualism. Perturbations ...
    • A reproducible approach to high-throughput biological data acquisition and integration 

      Börnigen, Daniela; Moon, Yo Sup; Rahnavard, Gholamali; Waldron, Levi; McIver, Lauren; Shafquat, Afrah; Franzosa, Eric A.; Miropolsky, Larissa; Sweeney, Christopher; Morgan, Xochitl C.; Garrett, Wendy S.; Huttenhower, Curtis (PeerJ Inc., 2015)
      Modern biological research requires rapid, complex, and reproducible integration of multiple experimental results generated both internally and externally (e.g., from public repositories). Although large systematic ...
    • The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers 

      Segata, Nicola; Baldini, Francesco; Pompon, Julien; Garrett, Wendy S.; Truong, Duy Tin; Dabiré, Roch K.; Diabaté, Abdoulaye; Levashina, Elena A.; Catteruccia, Flaminia (Nature Publishing Group, 2016)
      Microbes play key roles in shaping the physiology of insects and can influence behavior, reproduction and susceptibility to pathogens. In Sub-Saharan Africa, two major malaria vectors, Anopheles gambiae and An. coluzzii, ...
    • Sequence-Based Discovery of Bradyrhizobium enterica in Cord Colitis Syndrome 

      Bhatt, Ami Bharat; Freeman, Sam Spenser Sharpe; Herrera, Alex Francisco; Pedamallu, Chandra Sekhar; Gevers, Dirk; Duke, Fujiko; Jung, Joonil; Michaud, Monia; Walker, Bruce David; Young, Sally U.; Earl, Ashlee M.; Kostic, Aleksander D.; Ojesina, Akinyemi Ifedapo; Hasserjian, Robert Paul; Ballen, Karen Kuhn; Chen, Yi-Bin Albert; Hobbs, Gabriela; Antin, Joseph Harry; Soiffer, Robert Jon; Baden, Lindsey Robert; Garrett, Wendy S.; Hornick, Jason L.; Marty, Francisco Miguel; Meyerson, Matthew Langer (New England Journal of Medicine (NEJM/MMS), 2013)
      BACKGROUND—Immunosuppression is associated with a variety of idiopathic clinical syndromes that may have infectious causes. It has been hypothesized that the cord colitis syndrome, a complication of umbilical-cord ...
    • Tumor Necrosis Factor \(\alpha\) Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis 

      Shanmugam, Nanda Kumar Navalpur; Ellenbogen, Shiri; Trebicka, Estela; Wang, Lijian; Mukhopadhyay, Subhankar; Lacy-Hulbert, Adam; Gallini, Carey Ann; Garrett, Wendy S.; Cherayil, Bobby J. (Public Library of Science, 2012)
      Background: Abnormal expression of the liver peptide hormone hepcidin, a key regulator of iron homeostasis, contributes to the pathogenesis of anemia in conditions such as inflammatory bowel disease (IBD). Since little is ...