Now showing items 1-9 of 9

    • Catastrophic NAD+ Depletion in Activated T Lymphocytes Through Nampt Inhibition Reduces Demyelination and Disability in EAE 

      Bruzzone, Santina; Fruscione, Floriana; Morando, Sara; Ferrando, Tiziana; Poggi, Alessandro; Garuti, Anna; D'Urso, Agustina; Selmo, Martina; Benvenuto, Federica; Cea, Michele; Zoppoli, Gabriele; Moran, Eva; Soncini, Debora; Ballestrero, Alberto; Sordat, Bernard; Patrone, Franco; Uccelli, Antonio; Nencioni, Alessio; Mostoslavsky, Raul (Public Library of Science, 2009)
      Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD+ synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T ...
    • The histone deacetylase SIRT6, a critical modulator of metabolism and tumorigenesis 

      Sebastian, Carlos; Zhong, Lei; Silberman, Magali; Toiber, Deborah; Martinez, Barbara; Etchegaray, Jean-Pierre; Cosentino, Claudia; Giacosa, Sofia; Mostoslavsky, Raul (BioMed Central, 2012)
    • Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress 

      Shaughnessy, Daniel T.; McAllister, Kimberly; Worth, Leroy; Haugen, Astrid C.; Meyer, Joel N.; Domann, Frederick E.; Van Houten, Bennett; Mostoslavsky, Raul; Bultman, Scott J.; Baccarelli, Andrea A.; Begley, Thomas J.; Sobol, Robert W.; Hirschey, Matthew D.; Ideker, Trey; Santos, Janine H.; Copeland, William C.; Tice, Raymond R.; Balshaw, David M.; Tyson, Frederick L. (NLM-Export, 2014)
      Background: Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. ...
    • REST and the regulation of stress resistance, brain aging, and Alzheimer’s disease 

      Drake, Derek (2016-02-25)
      Understanding how age-related stress in the brain is managed over a lifetime to maintain neuronal and cognitive function and prevent neurodegeneration will be critical for developing therapies to promote healthy aging. ...
    • SIRT1 Activators: The Evidence STACks up 

      Kugel, Sita; Mostoslavsky, Raul (Impact Journals LLC, 2013)
    • SIRT6 Is Required for Normal Retinal Function 

      Silberman, Dafne M.; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; Apte, Rajendra S.; Mostoslavsky, Raul (Public Library of Science, 2014)
      The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding ...
    • Sirt6 regulates dendritic cell differentiation, maturation, and function 

      Lasigliè, Denise; Boero, Silvia; Bauer, Inga; Morando, Sara; Damonte, Patrizia; Cea, Michele; Monacelli, Fiammetta; Odetti, Paizio; Ballestrero, Alberto; Uccelli, Antonio; Mostoslavsky, Raul; Poggi, Alessandro; Nencioni, Alessio (Impact Journals LLC, 2016)
      Dendritic cells (DCs) are antigen-presenting cells that critically influence decisions about immune activation or tolerance. Impaired DC function is at the core of common chronic disorders and contributes to reduce ...
    • Sirt6 regulates TNFα secretion via hydrolysis of long chain fatty acyl lysine 

      Jiang, Hong; Khan, Saba; Wang, Yi; Charron, Guillaume; He, Bin; Sebastian, Carlos; Du, Jintang; Kim, Ray; Ge, Eva; Mostoslavsky, Raul; Hang, Howard C.; Hao, Quan; Lin, Hening (2013)
      The Sir2 family of enzymes or sirtuins are known as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases1 and have been implicated in the regulation of transcription, genome stability, metabolism, and lifespan2, ...
    • Sirtuins, Metabolism, and Cancer 

      Martinez-Pastor, Barbara; Mostoslavsky, Raul (Frontiers Research Foundation, 2012)
      More than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, ...