Now showing items 1-19 of 19

    • Amygdala Perfusion Is Predicted by Its Functional Connectivity with the Ventromedial Prefrontal Cortex and Negative Affect 

      Coombs III, Garth; Loggia, Marco L.; Greve, Douglas N.; Holt, Daphne J. (Public Library of Science, 2014)
      Background: Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction ...
    • Default mode network connectivity encodes clinical pain: An arterial spin labeling study 

      Loggia, Marco Luciano; Kim, Jieun; Gollub, Randy Lyanne; Vangel, Mark G.; Kirsch, Irving; Kong, Jian; Wasan, Ajay D.; Napadow, Vitaly J. (Ovid Technologies (Wolters Kluwer Health), 2013)
      Neuroimaging studies have suggested the presence of alterations in the anatomo-functional properties of the brain of patients with chronic pain. However, investigation of the brain circuitry supporting the perception of ...
    • Disentangling linear and nonlinear brain responses to evoked deep tissue pain 

      Loggia, Marco Luciano; Edwards, Robert R; Kim, Jieun; Vangel, Mark G.; Wasan, Ajay D.; Gollub, Randy Lyanne; Harris, Richard E.; Park, Kyungmo; Napadow, Vitaly J. (Ovid Technologies (Wolters Kluwer Health), 2012)
      Pain stimuli evoke widespread responses in the brain. However, our understanding of the physiological significance underlying heterogeneous response within different pain-activated and -deactivated regions is still limited. ...
    • Disrupted Brain Circuitry for Pain-Related Reward/Punishment in Fibromyalgia 

      Loggia, Marco Luciano; Berna, Chantal; Kim, Jieun; Cahalan, Christine M.; Gollub, Randy L.; Wasan, Ajay D.; Harris, Richard E.; Edwards, Robert R; Napadow, Vitaly J. (Wiley, 2013)
      Objective While patients suffering from fibromyalgia (FM) are known to exhibit hyperalgesia, the central mechanisms contributing to this altered pain processing are not fully understood. In this study we investigate ...
    • Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness 

      Akeju, Oluwaseun; Loggia, Marco L; Catana, Ciprian; Pavone, Kara J; Vazquez, Rafael; Rhee, James; Contreras Ramirez, Violeta; Chonde, Daniel B; Izquierdo-Garcia, David; Arabasz, Grae; Hsu, Shirley; Habeeb, Kathleen; Hooker, Jacob M; Napadow, Vitaly; Brown, Emery N; Purdon, Patrick L (eLife Sciences Publications, Ltd, 2014)
      Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination ...
    • Evoked itch perception is associated with changes in functional brain connectivity 

      Desbordes, Gaëlle; Li, Ang; Loggia, Marco L.; Kim, Jieun; Schalock, Peter C.; Lerner, Ethan; Tran, Thanh N.; Ring, Johannes; Rosen, Bruce R.; Kaptchuk, Ted J.; Pfab, Florian; Napadow, Vitaly (Elsevier, 2014)
      Chronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor ...
    • Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks 

      Kim, Hyungjun; Kim, Jieun; Loggia, Marco L.; Cahalan, Christine; Garcia, Ronald G.; Vangel, Mark G.; Wasan, Ajay D.; Edwards, Robert R.; Napadow, Vitaly (Elsevier, 2015)
      Altered brain morphometry has been widely acknowledged in chronic pain, and recent studies have implicated altered network dynamics, as opposed to properties of individual brain regions, in supporting persistent pain. ...
    • Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis 

      Alshikho, Mohamad J.; Zürcher, Nicole R.; Loggia, Marco L.; Cernasov, Paul; Chonde, Daniel B.; Izquierdo Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Lippincott Williams & Wilkins, 2016)
      Objective: In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation to glial activation in the same cohort of participants. Methods: Ten individuals with amyotrophic lateral sclerosis ...
    • The imagined itch: brain circuitry supporting nocebo-induced itch in atopic dermatitis patients 

      Napadow, Vitaly J.; Li, Ang; Loggia, Marco Luciano; Kim, Jieun; Mawla, Ishtiaq; Desbordes, Gaelle; Schalock, P. C.; Lerner, Ethan Arthur; Tran, Thanh-Nga Trinh; Ring, Johannes; Rosen, Bruce; Kaptchuk, Ted Jack; Pfab, Florian (Wiley-Blackwell, 2015)
      Background Psychological factors are known to significantly modulate itch in patients suffering from chronic itch. Itch is also highly susceptible to both placebo and nocebo (negative placebo) effects. Brain activity ...
    • Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28 

      Zürcher, Nicole R.; Loggia, Marco L.; Lawson, Robert; Chonde, Daniel B.; Izquierdo-Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Elsevier, 2015)
      Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo ...
    • The Lateral Prefrontal Cortex Mediates the Hyperalgesic Effects of Negative Cognitions in Chronic Pain Patients 

      Loggia, Marco Luciano; Berna, Chantal; Kim, Jieun; Cahalan, Christine M.; Martel, Marc-Olivier; Gollub, Randy Lyanne; Wasan, Ajay D.; Napadow, Vitaly J.; Edwards, Robert R (Elsevier BV, 2015)
      While high levels of negative affect and cognitions have been associated in chronic pain conditions with greater pain sensitivity, the neural mechanisms mediating the hyperalgesic effect of psychological factors in patients ...
    • Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling 

      Wasan, Ajay D.; Loggia, Marco Luciano; Chen, Li Q.; Napadow, Vitaly J.; Kong, Jian; Gollub, Randy Lyanne (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background The varying nature of chronic pain (CP) is difficult to correlate to neural activity using typical functional magnetic resonance imaging methods. Arterial spin labeling is a perfusion-based imaging technique ...
    • Neural Plasticity in Common Forms of Chronic Headaches 

      Lai, Tzu-Hsien; Protsenko, Ekaterina; Chen, Wei-Ta; Cheng, Yu-Chen; Loggia, Marco L.; Coppola, Gianluca (Hindawi Publishing Corporation, 2015)
      Headaches are universal experiences and among the most common disorders. While headache may be physiological in the acute setting, it can become a pathological and persistent condition. The mechanisms underlying the ...
    • OA08.04. Brain circuitry subserving acupuncture relief of itch in atopic dermatitis: an fMRI study 

      Napadow, Vitaly J.; Li, A.; Loggia, Marco Luciano; Kim, J.; Schalock, Peter C.; Lerner, Ethan Arthur; Rosen, Bruce; Kaptchuk, Ted Jack; Pfab, F (BioMed Central, 2012)
    • Phenotype Matters: The Absence of a Positive Association Between Cortical Thinning and Chronic Low Back Pain When Controlling for Salient Clinical Variables 

      Dolman, Andrew J.; Loggia, Marco Luciano; Edwards, Robert R; Gollub, Randy Lyanne; Kong, Jian; Napadow, Vitaly J.; Wasan, Ajay D. (Ovid Technologies (Wolters Kluwer Health), 2014)
      Studies have associated chronic low back pain (cLBP) with grey matter thinning. But these studies have not controlled for important clinical variables (such as a comorbid affective disorder, pain medication, age, or pain ...
    • Reply to the Letter to the Editor by Dr. Lampman (“What is a proper control group in fibromyalgia study?”) 

      Loggia, Marco Luciano; Edwards, Robert R; Harris, Richard E.; Napadow, Vitaly J. (Wiley, 2014)
    • S1 is associated with chronic low back pain: a functional and structural MRI study 

      Kong, Jian; Spaeth, Rosa B; Wey, Hsiao-Ying; Cheetham, Alexandra; Cook, Amanda H; Jensen, Karin; Tan, Ying; Liu, Hesheng; Wang, Danhong; Loggia, Marco L; Napadow, Vitaly; Smoller, Jordan W; Wasan, Ajay D; Gollub, Randy L (BioMed Central, 2013)
      A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we investigated 1) ...
    • The Somatosensory Link in Fibromyalgia: Functional Connectivity of the Primary Somatosensory Cortex Is Altered by Sustained Pain and Is Associated With Clinical/Autonomic Dysfunction 

      Kim, Jieun; Loggia, Marco Luciano; Cahalan, Christine M.; Harris, Richard E.; Beissner, Florian; Garcia, Ronald Gerardo; Kim, Hyungjun; Barbieri, Riccardo; Wasan, Ajay D.; Edwards, Robert R.; Napadow, Vitaly J. (Wiley-Blackwell, 2015)
      Objective Fibromyalgia (FM) is a chronic functional pain syndrome characterized by widespread pain, significant pain catastrophizing, sympathovagal dysfunction, and amplified temporal summation for evoked pain. While ...
    • Sustained deep-tissue pain alters functional brain connectivity 

      Kim, Jieun; Loggia, Marco Luciano; Edwards, Robert R; Wasan, Ajay D.; Gollub, Randy Lyanne; Napadow, Vitaly J. (Ovid Technologies (Wolters Kluwer Health), 2013)
      Recent functional brain connectivity studies have contributed to our understanding of the neurocircuitry supporting pain perception. However, evoked-pain connectivity studies have employed cutaneous and/or brief stimuli, ...