Browsing by Author "Culley, Deborah"
Now showing items 1-10 of 10
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Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Nature Publishing Group, 2014)Post-operative cognitive dysfunction (POCD) is associated with increased cost of care, morbidity, and mortality. However, its pathogenesis remains largely to be determined. Specifically, it is unknown why elderly patients ... -
Delirium is associated with early postoperative cognitive dysfunction
Rudolph, James; Marcantonio, Edward Ralph; Culley, Deborah Jean; Silverstein, J. H.; Rasmussen, L. S.; Crosby, Gregory; Inouye, Sharon (Wiley-Blackwell, 2008)The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The ... -
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia
Baxter, Mark G; Murphy, Kathy L; Crosby, Gregory; Culley, Deborah Jean (Wiley Subscription Services, Inc., A Wiley Company, 2007)Anesthetic protocols for behavioral neuroscience experiments are evolving as new anesthetics are developed and surgical procedures are refined to improve animal welfare. We tested whether neurotoxic dorsal hippocampal ... -
Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons
Zhang, Yiying; Pan, Chuxiong; Wu, Xu; Dong, Yuanlin; Culley, Deborah J.; Crosby, Gregory; Li, Tianzuo; Xie, Zhongcong (Frontiers Media S.A., 2014)Commonly used anesthetic isoflurane has been reported to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase-3 activation. However, the up-stream mechanisms of isoflurane’s effects remain largely to be ... -
Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia
Xie, Zhongcong; Dong, Y.; Maeda, U.; Moir, Robert D.; Inouye, Sharon; Culley, Deborah Jean; Crosby, Gregory; Tanzi, Rudolph Emile (Oxford University Press (OUP), 2006)Background. Dementia and delirium have been postulated to share common pathophysiologic mechanisms; however, identification of these unifying mechanisms has remained elusive. The inhalation anesthetic isoflurane has been ... -
Maximizing Clinical Research Participation in Vulnerable Older Persons: Identification of Barriers and Motivators
Marcantonio, Edward Ralph; Aneja, Jasneet; Jones, Richard Norman; Alsop, David C.; Fong, Tamara G; Crosby, Gregory; Culley, Deborah Jean; Cupples, L. Adrienne; Inouye, Sharon (Wiley-Blackwell, 2008)OBJECTIVES: To identify barriers and motivators to participation in long-term clinical research by high-risk elderly people and to develop procedures to maximize recruitment and retention. DESIGN: Quantitative and ... -
Peripheral Surgical Wounding and Age-Dependent Neuroinflammation in Mice
Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2014)Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to ... -
Prolonged Treatment with Propofol Transiently Impairs Proliferation but Not Survival of Rat Neural Progenitor Cells In Vitro
Palanisamy, Arvind; Friese, Matthew B.; Cotran, Emily; Moller, Ludde; Boyd, Justin D.; Crosby, Gregory; Culley, Deborah J. (Public Library of Science, 2016)Neurocognitive dysfunction is common in survivors of intensive care. Prolonged sedation has been implicated but the mechanisms are unclear. Neurogenesis continues into adulthood and is implicated in learning. The neural ... -
Review Article: Serum Biomarkers for Delirium
Marcantonio, Edward; Rudolph, James; Culley, Deborah; Crosby, Gregory; Alsop, David; Inouye, Sharon (Oxford University Press (OUP), 2006-12-01)This narrative review examines serum biomarkers for the diagnosis and monitoring of delirium. Serum biomarkers for delirium fall into three major groups: 1) those that are present or elevated prior to disease onset—risk ... -
Systemic Inflammation Impairs Attention and Cognitive Flexibility but Not Associative Learning in Aged Rats: Possible Implications for Delirium
Culley, Deborah J.; Snayd, Mary; Baxter, Mark G.; Xie, Zhongcong; Lee, In Ho; Rudolph, James; Inouye, Sharon K.; Marcantonio, Edward R.; Crosby, Gregory (Frontiers Media S.A., 2014)Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery ...