Now showing items 1-3 of 3

    • Complete integrin headpiece opening in eight steps 

      Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy A. (The Rockefeller University Press, 2013)
      Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured eight distinct RGD-bound conformations of the αIIbβ3 integrin headpiece. Starting from the closed βI domain conformation, we saw six intermediate βI ...
    • Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3 

      Springer, Timothy A.; Zhu, Jianghai; Xiao, Tsan (The Rockefeller University Press, 2008)
      Hemostasis and thrombosis (blood clotting) involve fibrinogen binding to integrin αIIbβ3 on platelets, resulting in platelet aggregation. αvβ3 binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen's α subunit. ...
    • Structural specializations of \(\alpha_4 \beta_7\), an integrin that mediates rolling adhesion 

      Yu, Yamei; Zhu, Jianghai; Mi, Li-Zhi; Walz, Thomas; Sun, Hao; Chen, JianFeng; Springer, Timothy A. (The Rockefeller University Press, 2012)
      The lymphocyte homing receptor integrin \(\alpha_4 \beta_7\) is unusual for its ability to mediate both rolling and firm adhesion. \(\alpha_4 \beta_1\) and \(\alpha_4 \beta_7\) are targeted by therapeutics approved for ...