Browsing by Author "Birrane, Gabriel"
Now showing items 1-4 of 4
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Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: Nuclear HO-1 promotes vascular endothelial growth factor secretion
BIRRANE, GABRIEL; LI, HUCHUN; YANG, SUPING; TACHADO, SOUVENIR D.; SENG, SEYHA (D.A. Spandidos, 2013)Prostate cancer is the second leading cause of male-cancer related death in the United States. Despite a number of evidence-based studies which strongly suggest an association between cigarette smoking and prostate cancer, ... -
Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing
Feng, Di; Steinke, Julia M.; Krishnan, Ramaswamy; Birrane, Gabriel; Pollak, Martin R. (Public Library of Science, 2016)Genetic testing in the clinic and research lab is becoming more routinely used to identify rare genetic variants. However, attributing these rare variants as the cause of disease in an individual patient remains challenging. ... -
Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1
Birrane, Gabriel; Mulvaney, Eamon P.; Pal, Rinku; Kinsella, B. Therese; Kocher, Olivier Nicolas (Public Library of Science, 2013)The prostanoid prostacyclin, or prostaglandin I2, plays an essential role in many aspects of cardiovascular disease. The actions of prostacyclin are mainly mediated through its activation of the prostacyclin receptor or, ... -
TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release
Bunch, Heeyoun; Zheng, Xiaofeng; Burkholder, Adam; Dillon, Simon T.; Motola, Shmulik; Birrane, Gabriel; Ebmeier, Christopher C.; Levine, Stuart; Fargo, David; Hu, Guang; Taatjes, Dylan J.; Calderwood, Stuart K. (2014)Summary Promoter proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in transcription. An unbiased search for novel human proteins that could regulate paused Pol II at the HSPA1B gene identified TRIM28. ...