Now showing items 1-10 of 10

    • CXCR3 Controls T-Cell Accumulation in Fat Inflammation 

      Rocha, V. Z.; Folco, Eduardo; Ozdemir, Cafer; Sheikine, Y.; Christen, T.; Sukhova, Galina K.; Tang, E. H. C.; Bittencourt, M. S.; Santos, R. D.; Luster, Andrew David; Cohen, David E; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine ...
    • Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality 

      Castillo, Melany; Hall, Jessica Ann; Correa-Medina, Mayrin; Ueta, Cintia; Won Kang, Hye; Cohen, David E.; Bianco, Antonio C. (American Diabetes Association, 2011)
      Objective: Thyroid hormone accelerates energy expenditure; thus, hypothyroidism is intuitively associated with obesity. However, studies failed to establish such a connection. In brown adipose tissue (BAT), thyroid hormone ...
    • Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis 

      Wagschal, Alexandre; Najafi-Shoushtari, S Hani; Wang, Lifeng; Goedeke, Leigh; Sinha, Sumita; deLemos, Andrew S; Black, Josh C; Ramírez, Cristina M; Li, Yingxia; Tewhey, Ryan; Hatoum, Ida; Shah, Naisha; Lu, Yong; Kristo, Fjoralba; Psychogios, Nikolaos; Vrbanac, Vladimir; Lu, Yi-Chien; Hla, Timothy T; de Cabo, Rafael; Tsang, John S; Schadt, Eric; Sabeti, Pardis Christine; Kathiresan, Sekar; Cohen, David E; Whetstine, Johnathan; Chung, Raymond Taeyong; Fernández-Hernando, Carlos; Kaplan, Lee Michael; Bernards, Andre; Gerszten, Robert Edgardo; Naar, Anders Michael (Springer Nature, 2015)
      Genome-wide association studies (GWASs) have linked genes to various pathological traits. However, the potential contribution of regulatory noncoding RNAs, such as microRNAs (miRNAs), to a genetic predisposition to ...
    • Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease 

      Kawano, Yuki; Cohen, David E. (Springer Japan, 2013)
      Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation in the absence of excess alcohol intake. NAFLD is the most common chronic liver disease, and ongoing research efforts are focused on ...
    • New players on the metabolic stage 

      Cohen, David E (Landes Bioscience, 2013)
      Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly ...
    • Racial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c 

      Edelstein, Leonard C.; Simon, Lukas M.; Montoya, Raúl Teruel; Holinstat, Michael; Chen, Edward S.; Bergeron, Angela; Kong, Xianguo; Nagalla, Srikanth; Mohandas, Narla; Cohen, David E.; Dong, Jing-fei; Shaw, Chad; Bray, Paul F. (2013)
      Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. PAR4 thrombin receptor ...
    • Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-\(\gamma\) Coactivator-1\(\alpha\) Expression 

      Estall, Jennifer Lynn; Kahn, Mario; Cooper, Marcus P.; Fisher, FFolliott Martin; Wu, Michele K.; Laznik, Dina; Qu, Lishu; Cohen, David Earl; Shulman, Gerald I.; Spiegelman, Bruce Michael (American Diabetes Association, 2009)
      Objective: The peroxisome proliferator–activated receptor-\(\gamma\) coactivator (PGC)-1 family of transcriptional coactivators controls hepatic function by modulating the expression of key metabolic enzymes. Hepatic gain ...
    • Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization 

      Demchev, Valeriy V; Malana, Geraldine; Vangala, Divya; Stoll, Janis; Desai, Anal; Kang, Hye-Won; Li, Yingxia; Nayeb-Hashemi, Hamed; Niepel, Michele W.; Cohen, David E; Ukomadu, Chinweike (Public Library of Science, 2013)
      Fibrinogen like protein 1(Fgl1) is a secreted protein with mitogenic activity on primary hepatocytes. Fgl1 is expressed in the liver and its expression is enhanced following acute liver injury. In animals with acute liver ...
    • Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue 

      Okada, Kosuke; LeClair, Katherine B.; Zhang, Yongzhao; Li, Yingxia; Ozdemir, Cafer; Krisko, Tibor I.; Hagen, Susan J.; Betensky, Rebecca A.; Banks, Alexander S.; Cohen, David E. (Elsevier, 2016)
      Objective: Non-shivering thermogenesis in brown adipose tissue (BAT) plays a central role in energy homeostasis. Thioesterase superfamily member 1 (Them1), a BAT-enriched long chain fatty acyl-CoA thioesterase, is upregulated ...
    • Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth 

      Cox, Andrew G.; Hwang, Katie L.; Brown, Kristin K.; Evason, Kimberley; Beltz, Sebastian; Tsomides, Allison; O'Connor, Keelin; Galli, Giorgio G.; Yimlamai, Dean; Chhangawala, Sagar; Yuan, Min; Lien, Evan C.; Wucherpfennig, Julia; Nissim, Sahar; Minami, Akihiro; Cohen, David E.; Camargo, Fernando D.; Asara, John M.; Houvras, Yariv; Stainier, Didier Y.R.; Goessling, Wolfram (2016)
      The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic ...