Now showing items 1-3 of 3

    • Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment 

      Klattenhoff, Carla A.; Scheuermann, Johanna C.; Surface, Lauren E.; Bradley, Robert K.; Fields, Paul A.; Steinhauser, Matthew L.; Ding, Huiming; Butty, Vincent L.; Torrey, Lillian; Haas, Simon; Abo, Ryan; Tabebordbar, Mohammadsharif; Lee, Richard Theodore; Burge, Christopher B.; Boyer, Laurie A. (Elsevier BV, 2013)
      Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. ...
    • Improving Stem Cell-Based Therapy and Developing a Novel Gene Therapy Approach for Treating Duchenne Muscular Dystrophy (DMD) 

      Tabebordbar, Mohammadsharif (2016-01-26)
      Genetic mutations in muscle structural genes can compromise myofiber integrity, causing repeated muscle damage that ultimately exhausts muscle regenerative capacity and results in devastating degenerative conditions such ...
    • Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction 

      Zangi, Lior; Lui, Kathy O; von Gise, Alexander; Ma, Qing; Ebina, Wataru; Ptaszek, Leon M.; Später, Daniela; Xu, Huansheng; Tabebordbar, Mohammadsharif; Gorbatov, Rostic; Sena, Brena; Nahrendorf, Matthias; Briscoe, David Michael; Li, Ronald A; Wagers, Amy Jo; Rossi, Derrick J; Pu, William T.; Chien, Kenneth R (Nature Publishing Group, 2013)
      In a cell-free approach to regenerative therapeutics, transient application of paracrine factors in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained clinical benefits. Here we show ...