Now showing items 1-7 of 7

    • Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome 

      Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)
      Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ...
    • CD39 and CD161 Modulate Th17 Responses in Crohn's Disease 

      Bai, Aiping; Moss, Alan; Kokkotou, Efi; Usheva, Anny; Sun, Xiaofeng; Cheifetz, Adam; Zheng, Yi; Longhi, Maria Serena; Gao, Wenda; Wu, Yan; Robson, Simon (The American Association of Immunologists, 2014-08-29)
      CD39 (ENTPD1) is expressed by subsets of pathogenic human CD4+ T cells, such as T helper type 17 (Th17) cells. These Th17 cells are considered important in intestinal inflammation, such as seen in Crohn’s disease. Recently, ...
    • Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients 

      Hall, Kathryn T; Tolkin, Benjamin R; Chinn, Garrett M; Kirsch, Irving; Kelley, John M; Lembo, Anthony J; Kaptchuk, Ted J; Kokkotou, Efi; Davis, Roger B; Conboy, Lisa A (BlackWell Publishing Ltd, 2014)
      Background: Attention to and perception of physical sensations and somatic states can significantly influence reporting of complaints and symptoms in the context of clinical care and randomized trials. Although anxiety and ...
    • In vitro correlates of HIV-2-mediated HIV-1 protection 

      Kokkotou, Efi G.; Sankale, J.L.; Mani, I.; Gueye-Ndiaye, A.; Schwartz, D.; Essex, Myron Elmer; Mboup, S.; Kanki, Phyllis Jean (Proceedings of the National Academy of Sciences, 2000)
      A prospective study of high-risk commercial sex workers in Senegal has shown that HIV-2 infection may reduce the risk of subsequent HIV-1 infection; these findings have been confirmed and extended, now with 13 years of ...
    • Intestinal Upregulation of Melanin-Concentrating Hormone in TNBS-Induced Enterocolitis in Adult Zebrafish 

      Geiger, Brenda M.; Gras-Miralles, Beatriz; Ziogas, Dimitrios C.; Karagiannis, Apostolos K. A.; Zhen, Aileen; Fraenkel, Paula; Kokkotou, Efi (Public Library of Science, 2013)
      Background: Melanin-concentrating hormone (MCH), an evolutionarily conserved appetite-regulating neuropeptide, has been recently implicated in the pathogenesis of inflammatory bowel disease (IBD). Expression of MCH is ...
    • Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome 

      Kaptchuk, Ted Jack; Friedlander, Elizabeth; Kelley, John Michael; Sanchez, M. Norma; Kokkotou, Efi G.; Singer, Joyce P.; Kowalczykowski, Magda; Miller, Franklin G.; Kirsch, Irving; Lembo, Anthony J. (Public Library of Science, 2010)
      Background: Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception. We tested whether open-label placebo (non-deceptive ...
    • Reduced Intestinal Tumorigenesis in APCmin Mice Lacking Melanin-Concentrating Hormone 

      Nagel, Jutta M.; Geiger, Brenda Mae; Karagiannis, Apostolos K. A.; Gras-Miralles, Beatriz; Horst, David; Najarian, Robert; Ziogas, Dimitrios C.; Chen, Xinhua; Kokkotou, Efi G. (Public Library of Science, 2012)
      Background: Melanin-concentrating hormone (MCH) is an evolutionary conserved hypothalamic neuropeptide that in mammals primarily regulates appetite and energy balance. We have recently identified a novel role for MCH in ...