Now showing items 1-8 of 8

    • Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis 

      Stankiewicz, James; Glanz, Bonnie; Healy, Brian Curran; Arora, Ashish; Neema, Mohit; Benedict, Ralph H.B.; Guss, Zachary D.; Tauhid, Shahamat Syed; Buckle, Guy J.; Houtchens, Maria K.; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit (Wiley-Blackwell, 2011)
      Background/Purpose: To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). Methods: Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed ...
    • Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis 

      Kivisäkk, Pia; Francois, Katiana; Mbianda, Julvet; Gandhi, Roopali; Weiner, Howard L.; Khoury, Samia J. (Public Library of Science, 2014)
      Objectives: Dendritic cells (DCs) serve a critical role both in promoting and inhibiting adaptive immunity. The goal of this study was to investigate the effect of natalizumab (NTZ) treatment on DC numbers, phenotype, and ...
    • The Impact of Lesion In-Painting and Registration Methods on Voxel-Based Morphometry in Detecting Regional Cerebral Gray Matter Atrophy in Multiple Sclerosis 

      Ceccarelli, A.; Jackson, J. S.; Tauhid, S.; Arora, A; Gorky, J.; Dell, E.; Bakshi, A.; Chitnis, Tanuja; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit; Neema, Mohit (American Society of Neuroradiology (ASNR), 2012)
      Background and Purpose: VBM has been widely used to study GM atrophy in MS. MS lesions lead to segmentation and registration errors that may affect the reliability of VBM results. Improved segmentation and registration ...
    • No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50 

      Bove, Riley; Musallam, Alexander; Healy, Brian C; Houtchens, Maria; Glanz, Bonnie I; Khoury, Samia; Guttmann, Charles R; De Jager, Philip L; Chitnis, Tanuja (BioMed Central, 2013)
      Background: The disease course in multiple sclerosis (MS) is influenced by many factors, including age, sex, and sex hormones. Little is known about sex-specific changes in disease course around age 50, which may represent ...
    • Persistent Inflammation Alters the Function of the Endogenous Brain Stem Cell Compartment 

      Pluchino, Stefano; Muzio, Luca; Alfaro-Cervello, Clara; Salani, Giuliana; Porcheri, Cristina; Brambilla, Elena; Cavasinni, Francesca; Bergamaschi, Andrea; Garcia-Verdugo, Jose Manuel; Comi, Giancarlo; Martino, Gianvito; Imitola, Jaime; Deleidi, Michela; Khoury, Samia Joseph (Oxford University Press, 2008)
      Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been ...
    • Pituitary volume measurements in malignant multiple sclerosis 

      W. M. Coronado, V.; Khoury, Samia; Chitnis, Tanuja (2013)
    • A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis 

      Xia, Zongqi; Chibnik, Lori; Glanz, Bonnie; Liguori, Maria; Shulman, Joshua M.; Tran, Dong; Khoury, Samia; Chitnis, Tanuja; Holyoak, Todd; Weiner, Howard; Guttmann, Charles; De Jager, Philip L. (Public Library of Science (PLoS), 2010-11-30)
      Background Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset ...
    • Tiam1/Rac1 complex controls Il17a transcription and autoimmunity 

      Kurdi, Ahmed T.; Bassil, Ribal; Olah, Marta; Wu, Chuan; Xiao, Sheng; Taga, Mariko; Frangieh, Michael; Buttrick, Thomas; Orent, William; Bradshaw, Elizabeth M.; Khoury, Samia J.; Elyaman, Wassim (Nature Publishing Group, 2016)
      RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family ...