Now showing items 1-6 of 6

    • Cellular Targets of Propranolol in Infantile Hemangioma 

      Lee, Daniel K (2014-02-25)
      Infantile hemangioma (IH) is a vascular neoplasm that affects 4-10 percent of infants. Propranolol, a non-selective beta-adrenergic receptor (AR) antagonist, was serendipitously discovered to accelerate regression of IH ...
    • Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing 

      Shi, Jinjun; Xu, Yingjie; Xu, Xiaoyang; Zhu, Xi; Pridgen, Eric; Wu, Jun; Votruba, Alexander R.; Swami, Archana; Zetter, Bruce Robert; Farokhzad, Omid Cameron (Elsevier BV, 2014)
      The development of controlled-release nanoparticle (NP) technologies has great potential to further improve the therapeutic efficacy of RNA interference (RNAi), by prolonging the release of small interfering RNA (siRNA) ...
    • Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer 

      Banyard, Jacqueline; Chung, Ivy; Migliozzi, Matthew; Phan, Derek T; Wilson, Arianne M; Zetter, Bruce R; Bielenberg, Diane R (BioMed Central, 2014)
      Background: Understanding the complex, multistep process of metastasis remains a major challenge in cancer research. Metastasis models can reveal insights in tumor development and progression and provide tools to test new ...
    • Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells 

      Piecewicz, Stephanie M.; Pandey, Ambarish; Roy, Bhaskar; Hua Xiang, Soh; Zetter, Bruce Robert; Sengupta, Shiladitya (Public Library of Science, 2012)
      The ability of embryonic stem cells to differentiate into endothelium and form functional blood vessels has been well established and can potentially be harnessed for therapeutic angiogenesis. However, after almost two ...
    • Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype 

      Connor, Yamicia; Tekleab, Sarah; Nandakumar, Shyama; Walls, Cherelle; Tekleab, Yonatan; Husain, Amjad; Gadish, Or; Sabbisetti, Venkata; Kaushik, Shelly; Sehrawat, Seema; Kulkarni, Ashish; Dvorak, Harold; Zetter, Bruce; Edelman, Elazer R.; Sengupta, Shiladitya (2015)
      Metastasis is a major cause of mortality and remains a hurdle in the search for a cure for cancer. Not much is known about metastatic cancer cells and endothelial cross-talk, which occurs at multiple stages during metastasis. ...
    • Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model 

      Banyard, Jacqueline; Chung, Ivy; Wilson, Arianne M.; Vetter, Guillaume; Le Béchec, Antony; Bielenberg, Diane R.; Zetter, Bruce R. (Nature Publishing Group, 2013)
      Using an in vivo cycling strategy, we selected metastatic cancer cells from the lymph nodes (LN) of mice bearing orthotopic DU145 human prostate tumors. Repeated rounds of metastatic selection (LN1–LN4) progressively ...