Now showing items 1-10 of 10

    • Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance 

      Liew, Chong Wee; Boucher, Jeremie; Cheong, Jit Kong; Vernochet, Cecile; Koh, Ho-Jin; Mallol, Cristina; Townsend, Kristy; Langin, Dominique; Kawamori, Dan; Hu, Jiang; Tseng, Yu-Hua; Hellerstein, Marc K; Farmer, Stephen R; Goodyear, Laurie; Doria, Alessandro; Blüher, Matthias; Hsu, Stephen I-Hong; Kulkarni, Rohit N (2012)
      SUMMARY Obesity develops due to altered energy homeostasis favoring fat storage. Here we describe a novel transcription co-regulator for adiposity and energy metabolism, TRIP-Br2 (also called SERTAD2). TRIP-Br2 null mice ...
    • Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools 

      Teo, Adrian Kee Keong; Gupta, Manoj K.; Doria, Alessandro; Kulkarni, Rohit N. (Elsevier, 2015)
      Background: Diabetes and metabolic syndromes are chronic, devastating diseases with increasing prevalence. Human pluripotent stem cells are gaining popularity in their usage for human in vitro disease modeling. With recent ...
    • The \(ENPP1\) Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals 

      Bacci, Simonetta; Rizza, Stefano; Prudente, Sabrina; Spoto, Belinda; Powers, Christine; Facciorusso, Antonio; Pacilli, Antonio; Lauro, Davide; Testa, Alessandra; Zhang, Yuan-Yuan; Di Stolfo, Giuseppe; Mallamaci, Francesca; Tripepi, Giovanni; Xu, Rui; Mangiacotti, Davide; Aucella, Filippo; Lauro, Renato; Copetti, Massimiliano; De Cosmo, Salvatore; Pellegrini, Fabio; Zoccali, Carmine; Federici, Massimo; Trischitta, Vincenzo; Gervino, Ernest Vincent; Hauser, Thomas Henry; Doria, Alessandro (American Diabetes Association, 2011)
      OBJECTIVE: Insulin resistance (IR) and cardiovascular disease may share a common genetic background. We investigated the role of IR-associated \(ENPP1\) K121Q polymorphism (rs1044498) on cardiovascular disease in high-risk ...
    • Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts 

      Qi, Qibin; Liang, Liming; Doria, Alessandro; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      Dyslipidemia has been associated with type 2 diabetes, but it remains unclear whether dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association between the genetic predisposition to dyslipdemia ...
    • Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes 

      Poznik, G. David; Mychaleckyj, Josyf C.; Barati, Michelle T.; Klein, Jon B.; Ng, Daniel P.K.; Placha, Grzegorz; Canani, Luis H.; Bochenski, Jacek; Waggott, Daryl; Merchant, Michael L.; Mirea, Lucia; Wanic, Krzysztof; Katavetin, Pisut; Kure, Masahiko; Wolkow, Pawel; Dunn, Jonathon S.; Smiles, Adam; Boright, Andrew P.; Bull, Shelley B.; Rich, Stephen S.; Warram, James H.; Pezzolesi, Marcus Guy; Paterson, Andrew D.; Krolewski, Bozena Krystyna; DCCT/EDIC Research Group; Krolewski, Andrzej Stefan; Walker, William H.; Doria, Alessandro; Rogus, John Joseph (American Diabetes Association, 2009)
      OBJECTIVE—Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of susceptibility genes and their variants has had limited success. To search for genes that contribute to ...
    • A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples 

      Sebastiani, Paola; Zhao, Zhenming; Abad-Grau, Maria M; Riva, Alberto; Sedgewick, Amanda E; Melista, Efthymia; Terry, Dellara; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T; Hartley, Stephen W.; Doria, Alessandro; Montano, Monty A. (BioMed Central, 2008)
      Background: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. Results: We present a ...
    • Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration 

      Asztalos, Bela F.; Schaefer, Ernst J.; Sell, David R.; Strauch, Christopher M.; Monnier, Vincent M.; Sun, Jennifer Katherine; Keenan, Hillary; Cavallerano, Jerry D.; Doria, Alessandro; Aiello, Lloyd Paul; King, George Liang (American Diabetes Association, 2011)
      Objective: To assess complication prevalence and identify protective factors in patients with diabetes duration of \(\geq\)50 years. Characterization of a complication-free subgroup in this cohort would suggest that some ...
    • Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes 

      Moreno, Lorena Ortega; Salvemini, Lucia; Mendonca, Christine; Copetti, Massimiliano; De Bonis, Concetta; De Cosmo, Salvatore; Doria, Alessandro; Trischitta, Vincenzo; Menzaghi, Claudia (Public Library of Science, 2015)
      Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is ...
    • Serum Resistin and Kidney Function: A Family-Based Study in Non-Diabetic, Untreated Individuals 

      Menzaghi, Claudia; Salvemini, Lucia; Fini, Grazia; Mangiacotti, Davide; Di Paola, Rosa; Morini, Eleonora; Giorelli, Maddalena; De Bonis, Concetta; De Cosmo, Salvatore; Trischitta, Vincenzo; Thompson, Ryan Wesley; Doria, Alessandro (Public Library of Science, 2012)
      Background: High serum resistin levels have been associated with kidney dysfunction. Most of these studies have been carried out in individuals with severe kidney impairment, diabetes, cardiovascular disease and related ...
    • Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes 

      Menzaghi, Claudia; Bacci, Simonetta; Salvemini, Lucia; Mendonca, Christine; Palladino, Giuseppe; Fontana, Andrea; De Bonis, Concetta; Marucci, Antonella; Goheen, Elizabeth; Prudente, Sabrina; Morini, Eleonora; Rizza, Stefano; Kanagaki, Alyssa; Fini, Grazia; Mangiacotti, Davide; Federici, Massimo; De Cosmo, Salvatore; Pellegrini, Fabio; Doria, Alessandro; Trischitta, Vincenzo (Public Library of Science, 2013)
      Background: High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, ...