Now showing items 1-16 of 16

    • Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy 

      Stephenson, Kathryn E.; Neubauer, George H.; Bricault, Christine A.; Shields, Jennifer; Bayne, Madeleine; Reimer, Ulf; Pawlowski, Nikolaus; Knaute, Tobias; Zerweck, Johannes; Seaman, Michael S.; Rosenberg, Eric S.; Barouch, Dan H. (Oxford University Press, 2016)
      The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses ...
    • Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells 

      Brumme, Zabrina L; Anastario, Michael; Cohen, Kristin W; Jolin, Jonathan S; Brumme, Chanson J; Streeck, Hendrik; Meier, Angela; Rosenberg, Eric Scott; Alter, Galit; Allen, Todd; Walker, Bruce David; Altfeld, Marcus (Public Library of Science, 2008)
      Background: Virus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic ...
    • CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects 

      Rodriguez, William Richard; Addo, Marylyn Martina; Rathod, Almas; Fitzpatrick, Cecily A; Yu, Xu; Perkins, Beth; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (BioMed Central, 2004)
      Background: CD8+ T cell responses are known to be important to the control of HIV-1 infection. While responses to reverse transcriptase and most structural and accessory proteins have been extensively studied, CD8 T cell ...
    • Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus 

      Tully, Damien C.; Ogilvie, Colin B.; Batorsky, Rebecca E.; Bean, David J.; Power, Karen A.; Ghebremichael, Musie; Bedard, Hunter E.; Gladden, Adrianne D.; Seese, Aaron M.; Amero, Molly A.; Lane, Kimberly; McGrath, Graham; Bazner, Suzane B.; Tinsley, Jake; Lennon, Niall J.; Henn, Matthew R.; Brumme, Zabrina L.; Norris, Philip J.; Rosenberg, Eric S.; Mayer, Kenneth H.; Jessen, Heiko; Kosakovsky Pond, Sergei L.; Walker, Bruce D.; Altfeld, Marcus; Carlson, Jonathan M.; Allen, Todd M. (Public Library of Science, 2016)
      Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the ...
    • Elite control of HIV infection: implications for vaccines 

      Miura, Toshiyuki; Rathod, Almas; Baker, Brett; Trocha, Alicja; Ueda, Peggy; Stone, David; Wrin, Terri; Buchbinder, Susan; Petropoulos, Christos J; Pereyra, Florencia M.; Addo, Marylyn Martina; Kaufmann, Daniel; Rosenberg, Rachel; Cohen, Daniel Aaron; Liu, Yang; Rosenberg, Eric Scott; Walker, Bruce David (BioMed Central, 2006)
    • Fully Differentiated HIV-1 Specific CD8+ T Effector Cells are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection 

      Draenert, Rika; Rathod, Almas; Verrill, Cori L.; Stone, David R.; Johnston, Mary N.; Flynn, Theresa; Addo, Marylyn Martina; Davis, Benjamin Thomas; Gandhi, Rajesh Tim; Robbins, Gregory Kimball; Basgov, Nesli; Cohen, Daniel E.; Wurcel, Alysse Gail; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (Public Library of Science, 2007)
      Background: CD8+ T cells impact control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. In HIV-1 infection, persistent HIV-1 specific IFN-γ+ CD8+ T cell responses ...
    • Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection 

      Li, Chun; Toth, Ilona; Schulze zur Wiesch, Julian; Pereyra, Florencia; Rychert, Jennifer Ann; Rosenberg, Eric Scott; van Lunzen, Jan; Lichterfeld, Mathias; Yu, Xu (Public Library of Science, 2013)
      Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses. While the ...
    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...
    • HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 

      Kalife, Elizabeth T; Qi, Ying; Johnston, Mary N; Burgett, Nicole; Swartz, Martha E; Yang, Amy; Rockstroh, Juergen K; Jessen, Heiko; Carrington, Mary; Altfeld, Marcus; Streeck, Hendrik; Lichterfeld, Mathias; Alter, Galit; Yu, Xu; Meier, Angela; Allen, Todd; Rosenberg, Eric Scott; Walker, Bruce David (Public Library of Science, 2006)
      Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. ...
    • Immune-Driven Recombination and Loss of Control after HIV Superinfection 

      Streeck, Hendrik; Li, Bin; Poon, Art F. Y.; Schneidewind, Anne; Gladden, Adrianne D.; Power, Karen A.; Daskalakis, Demetre; Bazner, Suzane; Zuniga, Rosario; Brander, Christian; Rosenberg, Eric Scott; Frost, Simon D. W.; Altfeld, Marcus; Allen, Todd (The Rockefeller University Press, 2008)
      After acute HIV infection, CD8^{+} T cells are able to control viral replication to a set point. This control is often lost after superinfection, although the mechanism behind this remains unclear. In this study, we ...
    • In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection 

      Lubong Sabado, Rachel; Kavanagh, Daniel Garrett; Kaufmann, Daniel; Fru, Karlhans; Babcock, Ethan; Rosenberg, Eric Scott; Walker, Bruce David; Lifson, Jeffrey; Bhardwaj, Nina; Larsson, Marie (Public Library of Science, 2009)
      Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ...
    • A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of an antiviral soluble factor 

      Rychert, Jennifer Ann; Jones, Lindsay; McGrath, Graham; Bazner, Sue; Rosenberg, Eric Scott (BioMed Central, 2013)
      Background: Lymphocyte Function-Associated Antigen-1 (LFA-1) likely plays a role in the pathogenesis of against HIV-1 and is known to facilitate cell-to-cell transmission of the virus. A monoclonal antibody specific for ...
    • P09-20 LB. Ultra-Deep Sequencing of Full-Length HIV-1 Genomes Identifies Rapid Viral Evolution During Acute Infection 

      Henn, MR; Lennon, N; Malboeuf, C; Charlebois, P; Philips, L; Berical, A; Erlich, R; Kemper, M; Axten, K; Brumme, Z; Brumme, C; Jessen, H; Nusbaum, C; Birren, B; Allen, TM; Boutwell, Christian Lane; Power, K; Gladden, Andrew B; Levin, Jonathan M.; Casali, Monica; Berlin, A; Anderson, S; Streeck, Hendrik; Ryan, Edward Thomas; Wang, Y; Green, L; Russ, Christiana Marie; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (BioMed Central, 2009)
    • Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection 

      Graham, Barney S.; Stocker, Vicki; Maenza, Janine; Markowitz, Martin; Little, Susan; Collier, Ann C.; Nabel, Gary; Saindon, Suzanne; Flynn, Theresa; Ostrowski, Mario A.; Rosenberg, Eric Scott; Chan, Ellen S.L.; Bosch, Ronald J.; Sax, Paul Edward; Kuritzkes, Daniel Robert; Barouch, Dan Hung (Public Library of Science, 2010)
      Background: An effective therapeutic vaccine that could augment immune control of HIV-1 replication may abrogate or delay the need for antiretroviral therapy. AIDS Clinical Trials Group (ACTG) A5187 was a phase I/II, ...
    • Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection 

      Vaidya, Sagar A; Streeck, Hendrik; Beckwith, Noor; Ghebremichael, Musie; Pereyra, Florencia; Kwon, Douglas S; Addo, Marylyn M; Rychert, Jenna; Routy, Jean-Pierre; Jessen, Heiko; Kelleher, Anthony D; Hecht, Frederick; Sekaly, Rafick-Pierre; Carrington, Mary; Walker, Bruce D; Allen, Todd M; Rosenberg, Eric S; Altfeld, Marcus (BioMed Central, 2013)
      Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control ...
    • Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection 

      Henn, Matthew R.; Charlebois, Patrick; Lennon, Niall J.; Power, Karen A.; Macalalad, Alexander R.; Berlin, Aaron M.; Malboeuf, Christine M.; Gnerre, Sante; Erlich, Rachel L.; Green, Lisa M.; Berical, Andrew; Wang, Yaoyu; Newman, Ruchi; Axten, Karen L.; Gladden, Adrianne D.; Battis, Laura; Kemper, Michael; Zeng, Qiandong; Shea, Terrance P.; Gujja, Sharvari; Zedlack, Carmen; Gasser, Olivier; Brander, Christian; Günthard, Huldrych F.; Brumme, Zabrina L.; Brumme, Chanson J.; Bazner, Suzane; Rychert, Jenna; Tinsley, Jake P.; Levin, Joshua Z.; Jessen, Heiko; Birren, Bruce W.; Boutwell, Christian Lane; Ryan, Elizabeth M.; Zody, Michael C.; Casali, Monica; Streeck, Hendrik; Bloom, Allyson Kelly; Dudek, Timothy E.; Tully, Damien C.; Hess, Christoph; Mayer, Kenneth Hugh; Rosenberg, Eric Scott; Pereyra, Florencia M.; Young, Sarah K.; Altfeld, Marcus; Walker, Bruce David; Allen, Todd (Public Library of Science, 2012)
      Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. ...