Now showing items 1-7 of 7

    • dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes 

      Korenjak, Michael; Kwon, Eunjeong; Morris, Robert T.; Anderssen, Endre; Amzallag, Arnaud; Ramaswamy, Sridhar; Dyson, Nicholas J. (Oxford University Press, 2014)
      dREAM complexes represent the predominant form of E2F/RBF repressor complexes in Drosophila. dREAM associates with thousands of sites in the fly genome but its mechanism of action is unknown. To understand the genomic ...
    • E2F and p53 Induce Apoptosis Independently during Drosophila Development but Intersect in the Context of DNA Damage 

      Moon, Nam-Sung; Morris, Erick J.; Patel, Reena; Di Stefano, Luisa; White, Kristin; Dyson, Nicholas John; Perrimon, Norbert (Public Library of Science, 2008)
      In mammalian cells, RB/E2F and p53 are intimately connected, and crosstalk between these pathways is critical for the induction of cell cycle arrest or cell death in response to cellular stresses. Here we have investigated ...
    • Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo 

      Morris, Erick J; Michaud, William A; Ji, Jun-Yuan; Moon, Nam-Sung; Rocco, James W; Dyson, Nicholas John (Public Library of Science, 2006)
      Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly ...
    • In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila 

      Ji, Jun-Yuan; Miles, Wayne O.; Korenjak, Michael; Zheng, Yani; Dyson, Nicholas J. (Genetics Society of America, 2012)
      The E2F transcription factors are important regulators of the cell cycle whose function is commonly misregulated in cancer. To identify novel regulators of E2F1 activity in vivo, we used Drosophila to conduct genetic ...
    • A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity 

      Longworth, Michelle S.; Walker, James Anthony; Anderssen, Endre; Moon, Nam-Sung; Gladden, Andrew; Heck, Margarete M. S.; Ramaswamy, Sridhar; Dyson, Nicholas John (Public Library of Science, 2012)
      Previously, we discovered a conserved interaction between RB proteins and the Condensin II protein CAP-D3 that is important for ensuring uniform chromatin condensation during mitotic prophase. The Drosophila melanogaster ...
    • Simian Virus 40 and Human Polyomavirus Oncogenic Perturbations 

      Berrios, Christian Jose (2016-07-25)
      Polyomaviruses have widespread prevalence across many animal species. Polyomaviruses are small DNA tumor viruses that endow their host cells with proliferative signals through interactions between their small T (ST) and ...
    • Transcriptional control of the autophagy-lysosome system in pancreatic cancer 

      Perera, Rushika M.; Stoykova, Svetlana; Nicolay, Brandon N.; Ross, Kenneth N.; Fitamant, Julien; Boukhali, Myriam; Lengrand, Justine; Deshpande, Vikram; Selig, Martin K.; Ferrone, Cristina R.; Settleman, Jeff; Stephanopoulos, Gregory; Dyson, Nicholas J.; Zoncu, Roberto; Ramaswamy, Sridhar; Haas, Wilhelm; Bardeesy, Nabeel (2016)
      Activation of cellular stress response pathways to maintain metabolic homeostasis is emerging as a critical growth and survival mechanism in many cancers1. The pathogenesis of pancreatic ductal adenocarcinoma (PDA) requires ...