Browsing by Author "Uchański, Tomasz"

Now showing items 1-2 of 2

    • Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer 

      Laverty, Duncan; Desai, Rooma; Uchański, Tomasz; Masiulis, Simonas; Stec, Wojciech J.; Malinauskas, Tomas; Zivanov, Jasenko; Pardon, Els; Steyaert, Jan; Miller, Keith; Aricescu, A. Radu (Springer Nature, 2019-01)
      Type A γ-aminobutyric acid receptors (GABAARs) are pentameric ligand-gated ion channels (pLGICs) and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system. Their dysfunction is implicated ...

    • GABAA receptor signalling mechanisms revealed by structural pharmacology 

      Masiulis, Simonas; Desai, Rooma; Uchański, Tomasz; Serna Martin, Itziar; Laverty, Duncan; Karia, Dimple; Malinauskas, Tomas; Zivanov, Jasenko; Pardon, Els; Kotecha, Abhay; Steyaert, Jan; Miller, Keith; Aricescu, A. Radu (Springer Nature, 2019-01)
      Type-A -aminobutyric receptors (GABAARs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs ...