Now showing items 1-17 of 17

    • Advanced nodal stage predicts venous thromboembolism in patients with locally advanced non-small cell lung cancer 

      Li, Richard Jay; Hermann, Gretchen; Baldini, Elizabeth Healey; Chen, Aileen Betty; Jackman, David M; Kozono, David Eiichi; Nguyen, Paul Linh; Nohria, Anju; Powell, Graham; Mak, Raymond Heungwing (Elsevier BV, 2016)
      Objectives: Patients with non-small cell lung cancer (NSCLC) are known to be at high risk for venous thromboembolism (VTE), but previous studies have not specifically analyzed locally advanced disease. We performed a ...
    • Aggressive therapy for patients with non-small cell lung carcinoma and synchronous brain-only oligometastatic disease is associated with long-term survival 

      Gray, Phillip; Mak, Raymond Heungwing; Yeap, Beow Yong; Cryer, Sarah K.; Pinnell, Nancy E.; Christianson, Laura W.; Sher, David J.; Arvold, Nils; Baldini, Elizabeth Healey; Chen, Aileen Betty; Kozono, David Eiichi; Swanson, Scott James; Jackman, David M; Alexander, Brian Michael (Elsevier BV, 2014)
      Objectives: Optimal therapy for patients with non-small cell lung carcinoma (NSCLC) presenting with synchronous brain-only oligometastases (SBO) is not well defined. We sought to analyze the effect of differing therapeutic ...
    • Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT 

      Huynh, Elizabeth; Coroller, Thibaud P.; Narayan, Vivek; Agrawal, Vishesh; Romano, John; Franco, Idalid; Parmar, Chintan; Hou, Ying; Mak, Raymond H.; Aerts, Hugo J. W. L. (Public Library of Science, 2017)
      Radiomics aims to quantitatively capture the complex tumor phenotype contained in medical images to associate them with clinical outcomes. This study investigates the impact of different types of computed tomography (CT) ...
    • Case report of tracheobronchial squamous cell carcinoma treated with radiation therapy and concurrent chemotherapy 

      Agrawal, Vishesh; Marcoux, J. Paul; Rabin, Michael Seth; Vernovsky, Inna; Wee, Jon O.; Mak, Raymond Heungwing (Elsevier BV, 2016)
      Tracheobronchial tumors include primary malignant tumors, secondary malignant tumors, and benign tumors. Primary malignant tumors of the trachea are rare, representing only 0.1% to 0.4% of all malignant disease. Squamous ...
    • Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease 

      Bradner, James Elliott; Mak, Raymond Heungwing; Tanguturi, Shyam Kumar; Mazitschek, Ralph; Haggarty, Stephen John; Ross, Kenneth N; Chang, Cindy Y.; Bosco, Jocelyn; West, Nathan; Morse, Elizabeth; Lin, Katherine; Shen, John Paul; Kwiatkowski, Nicholas Paul; Gheldof, Nele; Dekker, Job; DeAngelo, Daniel J.; Carr, Steven A.; Schreiber, Stuart L.; Golub, Todd Robert; Ebert, Benjamin L. (Proceedings of the National Academy of Sciences, 2010)
      The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications ...
    • CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma 

      Coroller, Thibaud Patrick; Grossmann, Patrick; Hou, Ying; Rios Velazquez, Emmanuel; Leijenaar, Ralph T.H.; Hermann, Gretchen; Lambin, Philippe; Haibe-Kains, Benjamin; Mak, Raymond Heungwing; Aerts, Hugo (Elsevier BV, 2015)
      Background and Purpose: Radiomics provides opportunities to quantify the tumor phenotype non-invasively by applying a large number of quantitative imaging features. This study evaluates computed-tomography (CT) radiomic ...
    • Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis 

      Novershtern, Noa; Subramanian, Aravind; Lawton, Lee N.; Mak, Raymond Heungwing; Haining, William Nicholas; McConkey, Marie E.; Habib, Naomi; Yosef, Nir; Chang, Cindy Hsin-Yu; Shay, Tal; Frampton, Garrett M.; Drake, Adam C.B.; Leskov, Ilya; Nilsson, Bjorn; Preffer, Frederic Ira; Dombkowski, David; Evans, John W.; Liefeld, Ted; Smutko, John S.; Chen, Jianzhu; Friedman, Nir; Young, Richard A.; Golub, Todd Robert; Regev, Aviv; Ebert, Benjamin L. (Elsevier BV, 2011)
      While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct ...
    • An Erythroid Differentiation Signature Predicts Response to Lenalidomide in Myelodysplastic Syndrome 

      Galili, Naomi; Tamayo, Pablo; Bosco, Jocelyn; Ladd-Acosta, Christine; Raza, Azra; Ebert, Benjamin L.; Mak, Raymond Heungwing; Pretz, Jennifer Lee; Tanguturi, Shyam Kumar; Stone, Richard Maury; Golub, Todd R. (Public Library of Science, 2008)
      Background: Lenalidomide is an effective new agent for the treatment of patients with myelodysplastic syndrome (MDS), an acquired hematopoietic disorder characterized by ineffective blood cell production and a predisposition ...
    • Evaluation of 3D fluoroscopic image generation from a single planar treatment image on patient data with a modified XCAT phantom 

      Mishra, Pankaj; Li, Ruijiang; James, Sara St; Mak, Raymond Heungwing; Williams, Christopher Leigh; Yue, Yong; Berbeco, Ross I.; Lewis, John Austin (IOP Publishing, 2013)
      Accurate understanding and modeling of respiration-induced uncertainties is essential in image-guided radiotherapy. Explicit modeling of overall lung motion and interaction among different organs promises to be a useful ...
    • Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology 

      Wu, Weimiao; Parmar, Chintan; Grossmann, Patrick; Quackenbush, John; Lambin, Philippe; Bussink, Johan; Mak, Raymond; Aerts, Hugo J. W. L. (Frontiers Media S.A., 2016)
      Background: Radiomics can quantify tumor phenotypic characteristics non-invasively by applying feature algorithms to medical imaging data. In this study of lung cancer patients, we investigated the association between ...
    • Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models 

      Herter-Sprie, Grit S.; Korideck, Houari; Christensen, Camilla L.; Herter, Jan M.; Rhee, Kevin; Berbeco, Ross I.; Bennett, David G.; Akbay, Esra A.; Kozono, David; Mak, Raymond H.; Makrigiorgos, G. Mike; Kimmelman, Alec C.; Wong, Kwok-Kin (2014)
      Close resemblance of murine and human trials is essential to achieve the best predictive value of animal-based translational cancer research. Kras-driven genetically engineered mouse models of non-small cell lung cancer ...
    • Low Incidence of Chest Wall Pain with a Risk-Adapted Lung Stereotactic Body Radiation Therapy Approach Using Three or Five Fractions Based on Chest Wall Dosimetry 

      Coroller, Thibaud P.; Mak, Raymond H.; Lewis, John H.; Baldini, Elizabeth H.; Chen, Aileen B.; Colson, Yolonda L.; Hacker, Fred L.; Hermann, Gretchen; Kozono, David; Mannarino, Edward; Molodowitch, Christina; Wee, Jon O.; Sher, David J.; Killoran, Joseph H. (Public Library of Science, 2014)
      Purpose To examine the frequency and potential of dose-volume predictors for chest wall (CW) toxicity (pain and/or rib fracture) for patients receiving lung stereotactic body radiotherapy (SBRT) using treatment planning ...
    • MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors 

      Lu, Jun; Guo, Shangqin; Ebert, Benjamin L.; Zhang, Hao; Peng, Xiao; Bosco, Jocelyn; Pretz, Jennifer Lee; Schlanger, Rita; Wang, Judy Y.; Mak, Raymond Heungwing; Dombkowski, David M.; Preffer, Frederic Ira; Scadden, David Thomas; Golub, Todd Robert (Elsevier BV, 2008)
      Lineage specification is a critical issue in developmental and regenerative biology. We hypothesized that microRNAs (miRNAs) are important participants in that process and used the poorly-understood regulation of ...
    • Outcomes by Tumor Histology and KRAS Mutation Status After Lung Stereotactic Body Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer 

      Mak, Raymond Heungwing; Hermann, Gretchen; Lewis, John H.; Aerts, Hugo J.W.L.; Baldini, Elizabeth Healey; Chen, Aileen Betty; Colson, Yolonda L.; Hacker, Fred L.; Kozono, David Eiichi; Wee, Jon O.; Chen, Yu-Hui; Catalano, Paul J.; Wong, Kwok-Kin; Sher, David J. (Elsevier BV, 2015)
      BACKGROUND: We analyzed outcomes after lung stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung-carcinoma (NSCLC) by histology and KRAS genotype. PATIENTS AND METHODS: We included 75 patients with 79 ...
    • Robust Radiomics Feature Quantification Using Semiautomatic Volumetric Segmentation 

      Parmar, Chintan; Rios Velazquez, Emmanuel; Leijenaar, Ralph; Jermoumi, Mohammed; Carvalho, Sara; Mak, Raymond H.; Mitra, Sushmita; Shankar, B. Uma; Kikinis, Ron; Haibe-Kains, Benjamin; Lambin, Philippe; Aerts, Hugo J. W. L. (Public Library of Science, 2014)
      Due to advances in the acquisition and analysis of medical imaging, it is currently possible to quantify the tumor phenotype. The emerging field of Radiomics addresses this issue by converting medical images into minable ...
    • A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy 

      Mak, Raymond Heungwing; Alexander, Brian Michael; Asomaning, Kofi; Heist, Rebecca Suk; Liu, Chen-yu; Su, Li; Zhai, Rihong; Ancukiewicz, Marek; Napolitano, Brian; Niemierko, Andrzej; Willers, Henning; Choi, Noah Chan H; Christiani, David Christopher (Wiley-Blackwell, 2011)
      Background: To study the association between functional single nucleotide polymorphisms (SNPs) in candidate genes from oxidative stress pathways, and risk of radiation pneumonitis (RP) in patients treated with thoracic ...
    • Volumetric CT-based segmentation of NSCLC using 3D-Slicer 

      Velazquez, Emmanuel Rios; Parmar, Chintan; Jermoumi, Mohammed; Mak, Raymond H.; van Baardwijk, Angela; Fennessy, Fiona M.; Lewis, John H.; De Ruysscher, Dirk; Kikinis, Ron; Lambin, Philippe; Aerts, Hugo J. W. L. (Nature Publishing Group, 2013)
      Accurate volumetric assessment in non-small cell lung cancer (NSCLC) is critical for adequately informing treatments. In this study we assessed the clinical relevance of a semiautomatic computed tomography (CT)-based ...