Now showing items 1-7 of 7

    • Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation 

      O'Rourke, Caitlin; Shelton, Georgia; Hutcheson, Joshua; Burke, Megan F.; Martyn, Trejeeve; Thayer, Timothy E.; Shakartzi, Hannah R.; Buswell, Mary D.; Tainsh, Robert; Yu, Binglan; Bagchi, Aranya; Rhee, David Kwan; Wu, Connie; Derwall, Matthias; Buys, Emmanuel; Yu, Paul B.; Bloch, Kenneth; Aikawa, Elena; Bloch, Donald Bendit; Malhotra, Rajeev (MyJove Corporation, 2016)
      Cardiovascular disease is the leading cause of morbidity and mortality in the world. Atherosclerotic plaques, consisting of lipid-laden macrophages and calcification, develop in the coronary arteries, aortic valve, aorta, ...
    • Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells 

      Hao, Jijun; Daleo, Marie A.; Murphy, Clare K.; Yu, Paul B.; Ho, Joshua N.; Hu, Jianyong; Peterson, Randall Theodore; Hatzopoulos, Antonis K.; Hong, Charles C. (Public Library of Science, 2008)
      Background: Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue types in the body, show great promise as a versatile source of cells for regenerative therapy. However, the basic ...
    • Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent 

      Wu, Xinggang; Yung, Lai-Ming; Cheng, Wai-Hang; Yu, Paul B.; Babitt, Jodie L.; Lin, Herbert Yih-Fuu; Xia, Yin (Public Library of Science, 2012)
      Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages. Hepcidin is synthesized mainly in the liver, ...
    • Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency 

      Malhotra, Rajeev; Burke, Megan F.; Martyn, Trejeeve; Shakartzi, Hannah R.; Thayer, Timothy E.; O’Rourke, Caitlin; Li, Pingcheng; Derwall, Matthias; Spagnolli, Ester; Kolodziej, Starsha A.; Hoeft, Konrad; Mayeur, Claire; Jiramongkolchai, Pawina; Kumar, Ravindra; Buys, Emmanuel S.; Yu, Paul B.; Bloch, Kenneth D.; Bloch, Donald B. (Public Library of Science, 2015)
      Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both ...
    • A New Class of Small Molecule Inhibitor of BMP Signaling 

      Sanvitale, Caroline E.; Kerr, Georgina; Chaikuad, Apirat; Ramel, Marie-Christine; Mohedas, Agustin Humberto; Reichert, Sabine; Wang, You; Triffitt, James T.; Cuny, Gregory D.; Yu, Paul B.; Hill, Caroline S.; Bullock, Alex N. (Public Library of Science, 2013)
      Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor ...
    • Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension 

      Long, Lu; Ormiston, Mark L.; Yang, Xudong; Southwood, Mark; Gräf, Stefan; Machado, Rajiv D.; Mueller, Matthias; Kinzel, Bernd; Yung, Lai Ming; Wilkinson, Janine M.; Moore, Stephen D.; Drake, Kylie M.; Aldred, Micheala A.; Yu, Paul; Upton, Paul D.; Morrell, Nicholas W. (2015)
      Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH). However, selective targeting of ...
    • Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants 

      Mohedas, Agustin H.; Wang, You; Sanvitale, Caroline E.; Canning, Peter; Choi, Sungwoon; Xing, Xuechao; Bullock, Alex N.; Cuny, Gregory D.; Yu, Paul B. (American Chemical Society, 2014)
      There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I ...