Browsing by Author "Ryter, Stefan W."
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Carbon Monoxide Protects against Hepatic Ischemia/Reperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β
Kim, Hyo Jeong; Jeong, Sun-Oh; Joe, Yeonsoo; Kong, Jin Sun; Cho, Gyeong Jae; Ryter, Stefan W.; Chung, Hun Taeg (Hindawi Publishing Corporation, 2013)Carbon monoxide (CO) may exert important roles in physiological and pathophysiological states through the regulation of cellular signaling pathways. CO can protect organ tissues from ischemia/reperfusion (I/R) injury by ... -
Carbon Monoxide: Present and Future Indications for a Medical Gas
Ryter, Stefan W.; Choi, Augustine M.K. (The Korean Association of Internal Medicine, 2013)Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., \(H_2S\), nitric oxide) ... -
Deacetylation of p53 induces autophagy by suppressing Bmf expression
Contreras, Amelia U.; Mebratu, Yohannes; Delgado, Monica; Montano, Gilbert; Hu, Chien-an A.; Ryter, Stefan W.; Choi, Augustine M.K.; Lin, Yuting; Xiang, Jialing; Chand, Hitendra; Tesfaigzi, Yohannes (The Rockefeller University Press, 2013)Interferon γ (IFN-γ)–induced cell death is mediated by the BH3-only domain protein, Bik, in a p53-independent manner. However, the effect of IFN-γ on p53 and how this affects autophagy have not been reported. The present ... -
Egr-1 Regulates Autophagy in Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease
Chen, Zhi-Hua; Kim, Hong Pyo; Sciurba, Frank C.; Feghali-Bostwick, Carol; Stolz, Donna B.; Dhir, Rajiv; Landreneau, Rodney J.; Schuchert, Mathew J.; Yousem, Samuel A.; Pilewski, Joseph M.; Lee, Janet S.; Zhang, Yingze; Lee, Seon-Jin; Nakahira, Kiichi; Ryter, Stefan W.; Choi, Augustine M.K. (Public Library of Science, 2008)Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is ... -
Identifying Targets for COPD Treatment Through Gene Expression Analyses
Chen, Zhi-Hua; Kim, Hong Pyo; Ryter, Stefan W.; Choi, Augustine M.K. (Dove Medical Press, 2008)Despite the status of chronic obstructive pulmonary disease (COPD) as a major global health problem, no currently available therapies can limit COPD progression. Therefore, an urgent need exists for the development of new ... -
The Impact of Autophagy on Cell Death Modalities
Ryter, Stefan W.; Mizumura, Kenji; Choi, Augustine M. K. (Hindawi Publishing Corporation, 2014)Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins, through a lysosome-dependent degradation pathway. During starvation, autophagy facilitates cell survival through the recycling ... -
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases
Choi, Alexander J.S.; Ryter, Stefan W. (Korean Society for Molecular and Cellular Biology, 2014)Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 ... -
Mitogen-Activated Protein Kinases Regulate Susceptibility to Ventilator-Induced Lung Injury
Dolinay, Tamás; Wu, Wei; Kaminski, Naftali; Ifedigbo, Emeka; Kaynar, A. Murat; Szilasi, Mária; Watkins, Simon C.; Ryter, Stefan W.; Hoetzel, Alexander; Choi, Augustine M.K. (Public Library of Science, 2008)Background: Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance ... -
Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells
Rayamajhi, Nabin; Kim, Seul-Ki; Go, Hiroe; Joe, Yeonsoo; Callaway, Zak; Kang, Jae-Gu; Ryter, Stefan W.; Chung, Hun Taeg (Hindawi Publishing Corporation, 2013)The regeneration of mitochondria by regulated biogenesis plays an important homeostatic role in cells and tissues and furthermore may provide an adaptive mechanism in certain diseases such as sepsis. The heme oxygenase ... -
Therapeutic Potential of Heme Oxygenase-1/Carbon Monoxide in Lung Disease
Constantin, Myrna; Choi, Alexander J. S.; Cloonan, Suzanne; Ryter, Stefan W. (Hindawi Publishing Corporation, 2012)Heme oxygenase (HO), a catabolic enzyme, provides the rate-limiting step in the oxidative breakdown of heme, to generate carbon monoxide (CO), iron, and biliverdin-IX\(\alpha\). Induction of the inducible form, HO-1, in ...