Browsing by Author "Chatila, Talal"

Now showing items 1-3 of 3

    • Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling 

      Charbonnier, Louis-Marie; Wang, Sen; Georgiev, Peter; Sefik, Esen; Chatila, Talal A (2015)
      Notch receptors direct the differentiation of T helper (TH) cell subsets, but their influence on regulatory T (Treg) cell responses is obscure. We here report that lineage-specific deletion of components of the Notch pathway ...

    • DOCK8 Functions as an Adaptor that Links TLR–MyD88 Signaling to B Cell Activation 

      Rauter, Ingrid; Recher, Mike; Wakim, Rima; Dbaibo, Ghassan; Dasouki, Majed; Barlan, Isil; Baris, Safa; Kutukculer, Necil; Ochs, Hans; Plebani, Alessandro; Kanariou, Maria; Lefranc, Gerard; Reisli, Ismail; Fitzgerald, Katerine; Golenbock, Douglas; Keles, Sevgi; Ceja, Reuben; Jabara, Haifa Halim; McDonald, Douglas Ray; Janssen, Erin Margaret; Massaad, Michel; Ramesh, Narayanaswamy; Borzutzky, Arturo; Benson, Halli Louise; Schneider, Lynda C.; Baxi, Sachin; Notarangelo, Luigi D.; Al-Herz, Waleed; Manis, John P.; Chatila, Talal Amine; Geha, Raif Salim (Nature Publishing Group, 2012)
      DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and \(CD27^+\) memory B cells were severely reduced in DOCK8-deficient patients. Toll-like receptor 9 (TLR9)- but ...

    • The Regulatory T Cell Response to Skeletal Muscle Injury and Its Decline With Age 

      Kuswanto, Wilson F. (2015-08-07)
      Efficient skeletal muscle regeneration requires the accumulation of Foxp3+CD4+ regulatory T (Treg) cells. Muscle Tregs have a transcriptome and T cell receptor repertoire distinct from Tregs found in other tissues. The ...