Browsing by Author "Gagne, Joshua"
Now showing items 1-17 of 17
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Active safety monitoring of newly marketed medications in a distributed data network: application of a semi-automated monitoring system
Gagne, Joshua J.; Glynn, Robert J.; Rassen, Jeremy A.; Walker, Alexander M.; Daniel, Gregory W.; Sridhar, Gayathri; Schneeweiss, Sebastian (2014)We developed a semi-automated active monitoring system that uses sequential matched-cohort analyses to assess drug safety across a distributed network of longitudinal electronic healthcare data. In a retrospective analysis, ... -
Availability and utilization of cardiovascular fixed-dose combination drugs in the United States
Wang, Bo; Choudhry, Niteesh Kumar; Gagne, Joshua J; Landon, Joan; Kesselheim, Aaron Seth (Elsevier BV, 2015)BACKGROUND: Solid clinical evidence supports the effectiveness and safety of multiple drugs in treating diabetes, dyslipidemia, and hypertension, and numerous fixed-dose combination products (FDCs) containing such drugs ... -
Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes
Gagne, Joshua J; Choudhry, Niteesh Kumar; Kesselheim, Aaron Seth; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (American College of Physicians, 2014)Background: Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them. Objective: To determine whether patients are more adherent to generic statins versus brand-name statins ... -
Comparative effectiveness of generic versus brand-name antiepileptic medications
Gagne, Joshua J; Kesselheim, Aaron Seth; Choudhry, Niteesh Kumar; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (Elsevier BV, 2015)OBJECTIVE: The objective of this study was to compare treatment persistence and rates of seizure-related events in patients who initiate antiepileptic drug (AED) therapy with a generic versus a brand-name product. METHODS: ... -
Dimension reduction and shrinkage methods for high dimensional disease risk scores in historical data
Kumamaru, Hiraku; Schneeweiss, Sebastian; Glynn, Robert J.; Setoguchi, Soko; Gagne, Joshua J. (BioMed Central, 2016)Background: Multivariable confounder adjustment in comparative studies of newly marketed drugs can be limited by small numbers of exposed patients and even fewer outcomes. Disease risk scores (DRSs) developed in historical ... -
Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison
Gagne, Joshua J; Bykov, Katsiaryana; Choudhry, Niteesh K; Toomey, Timothy J; Connolly, John G; Avorn, Jerry (BMJ Publishing Group Ltd., 2013)Objective: To evaluate whether smoking status is associated with the efficacy of antiplatelet treatment in the prevention of cardiovascular events. Design: Systematic review, meta-analysis, and indirect comparisons. Data ... -
Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study
Pottegård, Anton; Friis, Søren; Christensen, René dePont; Habel, Laurel A.; Gagne, Joshua J.; Hallas, Jesper (Elsevier, 2016)Purpose We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. Methods: We identified all patients (cases) with ... -
Innovative research methods for studying treatments for rare diseases: methodological review
Gagne, Joshua J; Thompson, Lauren; O’Keefe, Kelly; Kesselheim, Aaron S (BMJ Publishing Group Ltd., 2014)Objective: To examine methods for generating evidence on health outcomes in patients with rare diseases. Design: Methodological review of existing literature. Setting: PubMed, Embase, and Academic Search Premier searched ... -
Lessons Learned Obtaining Informed Consent in Research with Vulnerable Populations in Community Health Center Settings
Riden, Heather E; Grooms, Kya N; Clark, Cheryl; Cohen, Laura R; Gagne, Joshua J; Tovar, Dora A; Ommerborn, Mark J; Orton, Piper S; Johnson, Paula Adina (BioMed Central, 2012)Background: To improve equity in access to medical research, successful strategies are needed to recruit diverse populations. Here, we examine experiences of community health center (CHC) staff who guided an informed consent ... -
Long-Term Use of Cardiovascular Medications: Identifying and Encouraging Optimal Duration
Krumme, Alexis A. (2017-09-20)In the face of increasingly widespread availability and uptake of medications to treat and prevent cardiovascular disease, this dissertation is motivated by two broad research questions regarding the duration of cardiovascular ... -
Near-Real-Time Monitoring of New Drugs: An Application Comparing Prasugrel Versus Clopidogrel
Gagne, Joshua J; Rassen, Jeremy Alfred; Choudhry, Niteesh K; Bohn, R. L.; Patrick, Amanda; Sridhar, G; Daniel, G W; Liu, Jun; Schneeweiss, Sebastian (Springer Science + Business Media, 2014)BACKGROUND: Methods for near-real-time monitoring of new drugs in electronic healthcare data are needed. OBJECTIVE: In a novel application, we prospectively monitored ischemic, bleeding, and mortality outcomes among patients ... -
Physicians’ Trust in the FDA’s Use of Product-Specific Pathways for Generic Drug Approval
Kesselheim, Aaron Seth; Eddings, Wesley; Raj, Tara; Campbell, Eric G.; Franklin, Jessica Myers; Ross, Kathryn M.; Fulchino, Lisa A.; Avorn, Jerry Lewis; Gagne, Joshua J (Public Library of Science (PLoS), 2016)Background: Generic drugs are cost-effective versions of brand-name drugs approved by the Food and Drug Administration (FDA) following proof of pharmaceutical equivalence and bioequivalence. Generic drugs are widely ... -
Potentially disruptive life events: what are the immediate impacts on chronic disease management? A case-crossover analysis
Lauffenburger, Julie C; Gagne, Joshua J; Song, Zirui; Brill, Gregory; Choudhry, Niteesh K (BMJ Publishing Group, 2016)Objective: To explore the association between unexpected potentially disruptive life events in a patient or family member that may challenge an individual's ability to take medications as prescribed and the discontinuation ... -
Selective Serotonin Reuptake Inhibitor Use and Perioperative Bleeding and Mortality in Patients Undergoing Coronary Artery Bypass Grafting: A Cohort Study
Gagne, Joshua J; Polinski, Jennifer Milan; Rassen, Jeremy; Fischer, Michael Adam; Seeger, John; Franklin, Jessica Myers; Liu, Jun; Schneeweiss, Sebastian; Choudhry, Niteesh Kumar (Springer Science + Business Media, 2015)INTRODUCTION: Several small studies have reported inconsistent findings about the safety of selective serotonin reuptake inhibitors (SSRIs) among patients undergoing coronary artery bypass grafting (CABG). We sought to ... -
Summary Score-Based Confounding Control in Studies of New Drugs
Bohn, Justin (2017-09-21)Epidemiological studies of newly marketed drugs are often undertaken to assess questions of safety and effectiveness that did not arise during a drug’s pre-approval studies. However, unlike in randomized controlled trials, ... -
Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study
Bateman, Brian T; Bykov, Katsiaryna; Choudhry, Niteesh K; Schneeweiss, Sebastian; Gagne, Joshua J; Polinski, Jennifer M; Franklin, Jessica M; Doherty, Michael; Fischer, Michael A; Rassen, Jeremy A (BMJ Publishing Group Ltd., 2013)Objective: To examine the relation between the type of stress ulcer prophylaxis administered and the risk of postoperative pneumonia in patients undergoing coronary artery bypass grafting. Design: Retrospective cohort ... -
A Unified Framework for Classification of Methods for Benefit-Risk Assessment
Najafzadeh, Mehdi; Schneeweiss, Sebastian; Choudhry, Niteesh Kumar; Bykov, Katsiaryna; Kahler, Kristijan H.; Martin, Diane P.; Gagne, Joshua J (Elsevier BV, 2015)BACKGROUND: Patients, physicians, and other decision makers make implicit but inevitable trade-offs among risks and benefits of treatments. Many methods have been proposed to promote transparent and rigorous benefit-risk ...