Browsing by Author "Lashkari, Kameran"
Now showing items 1-4 of 4
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c-Met Modulates RPE Migratory Response to Laser-Induced Retinal Injury
Kasaoka, Masataka; Ma, Jie; Lashkari, Kameran (Public Library of Science, 2012)Retinal laser injuries are often associated with aberrant migration of the retinal pigment epithelium (RPE), which can cause expansion of the scar beyond the confines of the original laser burn. In this study, we devised ... -
Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation
Ma, Jie; Mehta, Manisha; Lam, Godfrey; Cyr, Desireé; Ng, Tat Fong; Hirose, Tatsuo; Tawansy, Khaled A.; Taylor, Andrew W.; Lashkari, Kameran (Molecular Vision, 2014)Purpose The clinical phenotype of advanced stage retinopathy of prematurity (ROP, stages 4 and 5) cannot be replicated in an animal model. To dissect the molecular events that can lead up to advanced ROP, we examined ... -
NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration
Tseng, Wenche; Thein, Thuzar; Kinnunen, Kati; Lashkari, Kameran; Gregory, Meredith S.; D'Amore, Patricia Ann; Ksander, Bruce R. (Association for Research in Vision and Ophthalmology (ARVO), 2013)Purpose.: To evaluate the effect of lysosomal destabilization on NLRP3 inflammasome activation in RPE cells and to investigate the mechanisms by which inflammasome activation may contribute to the pathogenesis of age-related ... -
Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival
Ma, Jie; Guo, Chenying; Guo, Caiwei; Sun, Yu; Liao, Tiffany; Beattie, Ursula; López, Francisco J.; Chen, Dong Feng; Lashkari, Kameran (Public Library of Science, 2015)We have previously characterized human neuronal progenitor cells (hNP) that can adopt a retinal ganglion cell (RGC)-like morphology within the RGC and nerve fiber layers of the retina. In an effort to determine whether ...